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Clinical reviews
Pediatric Anesthesiology Review Clinical Cases for Self Assessment
Boston Children’s Hospital
·
Pediatric Anesthesiology
· 770 pages
A third‑edition review book presenting pediatric anesthesiology case scenarios for self‑assessment and learning.
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Clinical reviews
LIFETIME BENEFITS OF COMPREHENSIVE MEDICAL THERAPY IN HEART FAILURE WITH MILDLY REDUCED OR PRESERVED EJECTION FRACTION
Nature Medicine
·
Cardiology
· 2025
· 40 pages
This document discusses the long-term benefits of comprehensive medical therapy for patients with heart failure, particularly focusing on those with mildly reduced or preserved ejection fraction.
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Clinical reviews
1. hantavirus in humans
Infectious disease
· 12 pages
A review of hantavirus infections focusing on cardiopulmonary syndrome and hemorrhagic fever with renal syndrome, covering transmission, clinical presentation, and diagnostic approaches.
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Clinical reviews
METFORMIN―MECHANISMS OF ITS GLYCEMIA-REDUCING EFFECT
Division of Clinical Pharmacology & Toxicology, University Hospital Basel; Max Zeller Sohne Ltd; CNRS, INSERM, Institut Cochin, Université Paris Cité; Epatocentro Ticino
·
Endocrinology
· 2026
· 45 pages
This review article explores the pharmacological mechanisms by which metformin reduces glycemia, focusing on its effects on glucose metabolism, pharmacokinetics, and clinical applications.
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Clinical reviews
Updates on Heart Failure Management (2)
Uganda Heart Institute
·
Cardiology
· 24 pages
A concise overview of recent advances and recommendations in the management of heart failure.
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Clinical reviews
Myeloproliferative Neoplasms
INSERM Unité Mixte de Recherche 1287, Gustave Roussy
·
Hematology
· 2026
· 15 pages
Classic myeloproliferative neoplasms, including essential thrombocythemia, polycythemia vera, and primary myelofibrosis, are chronic, clonal hematopoietic stem-cell disorders driven by gain-of-function mutations in JAK2, CALR, or MPL. These mutations confer a clonal advantage, and inflammation can shape disease development, potentially leading to myelofibrosis, thrombotic complications, or secondary acute myeloid leukemia.
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Clinical reviews
EXERTIONAL HEAT ILLNESS: A CLINICAL AND EVIDENCE-BASED GUIDE
University of North Carolina at Greensboro, University of Connecticut
·
Sports Medicine
· 2020
· 275 pages
This guide provides a comprehensive overview of exertional heat illnesses, including their recognition, treatment, and prevention strategies based on current evidence.
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Clinical reviews
ACUTE PANCREATITIS: MECHANISMS AND THERAPEUTIC APPROACHES
Qian Hu, Yue Hu, Chunlu Tan, Yue Yang, Hang Su, Zixing Huang, Wenfu Tang, Rui Wang, Jingping Liu, Meihua Wan
·
Gastroenterology
· 2026
· 43 pages
This review provides a structured summary of current knowledge regarding the definition and classification of acute pancreatitis, along with recent advances in clinical scoring systems, biomarkers, and predictive models based on artificial intelligence.
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Clinical reviews
ANTIPLATELET MANAGEMENT IN THE MANAGEMENT OF ATHEROSCLEROTIC CARDIOVASCULAR DISEASE
American College of Cardiology
·
Cardiology
· 2026
· 30 pages
This scientific statement provides a detailed overview of current evidence for the use of antiplatelets in the management of atherosclerotic cardiovascular disease (ASCVD). It discusses the evolution of recommendations and the balance between preventing ischemic events and the risk of bleeding.
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Clinical reviews
NON -‐ COMMUNICABLE DISEASE RISK FACTOR BASELINE SURVEY UGANDA 2014 REPORT
MINISTRY OF HEALTH
·
Public Health
· 2014
· 206 pages
This report presents the findings of a baseline survey on non-communicable disease risk factors in Uganda, detailing various health metrics and risk factors among the population.
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Clinical reviews
CORTICOSTEROIDS IN ARDS: OLD CONTROVERSIES, NEW INSIGHTS, AND FUTURE DIRECTIONS
null
·
Intensive Care Medicine
· 2026
· 15 pages
This narrative review discusses the role of corticosteroids in the treatment of Acute Respiratory Distress Syndrome (ARDS), highlighting the complexities of their use across different patient phenotypes and conditions.
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Clinical reviews
THE ORAL MICROBIOME IN THE PATHOPHYSIOLOGY OF CARDIOVASCULAR DISEASE
Andrea Tonelli, Evelyn N. Lumngwena, Ntobeko A. B. Ntusi
·
Cardiology
· 2022
· 18 pages
This review examines the link between the oral microbiome and cardiovascular diseases (CVD), including coronary artery disease, stroke, and heart failure. It highlights the mechanisms by which oral dysbiosis may influence CVD progression.
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Clinical reviews
MECHANICAL VENTILATION IN THE CRITICALLY ILL OBESE PATIENT
Hospital Morales Meseguer, Schaffner Hospital
·
Intensive Care Medicine
· 2018
· 305 pages
This document discusses the principles and practices of mechanical ventilation specifically tailored for critically ill obese patients, addressing unique challenges and considerations.
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Clinical reviews
PRE-ECLAMPSIA
University of Melbourne, Royal Women’s Hospital, Monash Health, Monash University, Instituto Nacional de Perinatologia, University of Tokyo, Chiba University, Universidade de Sao Paulo, Fetal Medicine Foundation, King’s College Hospital
·
Obstetrics and Gynecology
· 2023
· 22 pages
Pre-eclampsia is a life-threatening disease of pregnancy unique to humans and a leading cause of maternal and neonatal morbidity and mortality. It is characterized by sudden-onset hypertension and other complications, significantly impacting both maternal and fetal health.
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Clinical reviews
Exploring treatment options in cancer: tumor treatment strategies
Dr. Saar Gill and Dr. Beilei Liu, Hongyu Zhou, Licheng Tan, Kin To Hugo Siu, Xin-Yuan Guan
·
Oncology
· 2024
· 44 pages
This review discusses various treatment modalities for cancer, including small molecule targeted drugs, antibody-drug conjugates, cell therapies, and gene therapies, highlighting their development status and clinical challenges.
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Clinical reviews
INCLUSION BODY MYOSITIS
UC Irvine-MDA ALS and Neuromuscular Center
·
Neurology
· 2022
· 15 pages
This review article provides insights into the pathomechanisms and therapeutic strategies of inclusion body myositis (IBM), highlighting its clinical and diagnostic features.
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Clinical reviews
JUNCTIONAL TACHYCARDIA: A CRITICAL REASSESSMENT
American College of Cardiology Foundation
·
Cardiology
· 2023
· 17 pages
This document provides a contemporary review of junctional tachycardia (JT), discussing its mechanisms and implications for diagnosis and treatment, particularly in relation to ablation strategies.
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Clinical reviews
REFINING THE ROLE OF BETA-BLOCKERS INCARDIOVASCULAR MEDICINE
Saint Luke’s Mid America Heart Institute, University of Missouri, Mount Sinai Fuster Heart Hospital, Ziekenhuis Oost-Limburg, UHasselt, Cooper Medical School of Rowan University, Cleveland Clinic Foundation
·
Cardiology
· 2026
· 22 pages
This document reviews the evolving role of beta-blockers in cardiovascular care, highlighting recent trials and analyses that challenge longstanding practices. It discusses the implications of these findings for clinical practice and patient management.
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Clinical reviews
SEPSIS DEFINITIONS, PATHOPHYSIOLOGY AND THE CHALLENGE OF BEDSIDE MANAGEMENT
Alpert/Brown Medical School
·
Pulmonary Critical Care
· 2017
· 271 pages
This document provides a comprehensive overview of sepsis, including its definitions, underlying pathophysiology, and the challenges faced in managing it at the bedside.
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Clinical reviews
METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS
Various institutions including University of North Carolina, Geneva University Hospitals, The University of Melbourne, Hallym University, Duke University, Mayo Clinic
·
Infectious Diseases
· 2026
· 23 pages
This document provides a comprehensive overview of methicillin-resistant Staphylococcus aureus (MRSA), including its epidemiology, mechanisms of pathophysiology, diagnosis, management, and quality of life considerations for affected patients.
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Clinical reviews
Efficacy and Safety of Daprodustat for Treatment of Anemia of Chronic
Ajay K. Singh
·
nephrology
· 528 pages
A randomized, open‑label clinical trial comparing daprodustat with darbepoetin alfa for anemia management in patients starting dialysis.
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Clinical reviews
LEISHMANIASIS
Department of Pathology, Wexner Medical Center, Ohio State University
·
Infectious Disease
· 2026
· 14 pages
Leishmaniasis comprises clinically distinct diseases caused by the protozoan parasite Leishmania, transmitted through the bite of infected sand flies. This review discusses the various forms of leishmaniasis, their clinical manifestations, diagnosis, and treatment options.
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Clinical reviews
LIPOPROTEIN(A) AND WOMEN'S CARDIOVASCULAR HEALTH
Erin D. Michos, MD, MHS, Stephanie Saucier, MD, Roxana Mehran, MD, Marlys L. Koschinsky, PhD
·
Cardiology
· 2026
· 11 pages
This review discusses the role of elevated lipoprotein(a) as a risk factor for cardiovascular disease in women, highlighting the influence of female sex hormones on lipoprotein metabolism and the need for improved management strategies.
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Clinical reviews
PULMONARY HYPERTENSION ASSOCIATED WITH LEFT HEART DISEASE: CHALLENGES, EMERGING STRATEGIES, AND FUTURE DIRECTIONS
American College of Cardiology Foundation
·
Cardiology
· 2026
· 35 pages
This review discusses pulmonary hypertension associated with left heart disease, highlighting its prevalence, diagnostic challenges, and emerging treatment strategies. It summarizes current knowledge and proposes a framework for future investigations.
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