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Clinical reviews
IMPACT OF CREATINE SUPPLEMENTATION ON KIDNEY HEALTH: A SYSTEMATIC REVIEW AND META-ANALYSIS
Artur de Souza Almeida, Leonardo Olimpio Dias da Silva, Bianca Namie Abe Takahasi, Bruno Damico Terada, Felipe Giraldo Alvarez Gonçalves, Breno Cordeiro Porto, Rodrigo Afonso da Silva Sardenberg, Carlo Camargo Passerotti, Ronaldo Soares Maia, Farid
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The review systematically searched databases including MEDLINE, Embase, Cochrane Library, and Google Scholar for studies assessing the impact of creatine supplementation on kidney health. A total of 26 studies involving 1036 participants were included, focusing on outcomes such as serum creatinine levels and glomerular filtration rate (GFR). The findings indicate a significant increase in serum creatinine levels and a reduction in GFR when assessed by creatinine-based methods, highlighting the need for careful consideration of creatine use in individuals with kidney concerns.
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