Osler Collection

Antibiotics & Antimicrobial Stewardship

Prescribing guidance, antibiograms, AMR in Uganda, ESBL/polymyxin guidance, duration of therapy and penicillin-allergy workarounds.

12 resources

This collection provides resources on antibiotic prescribing and antimicrobial resistance, specifically tailored for clinicians in Uganda and East Africa. It includes guidelines, clinical notes, and reports that address common infections, resistance patterns, and stewardship practices.

01Guidelines & protocolsAntimicrobial Prescribing Guidance for Common InfectionsNICEInfectious Disease· 2025· 31 pagesGuidance on managing common infections, including dental, eye, skin, and genital infections, with information on antimicrobial prescribing and dosing.Start here — prescribing guidance for common infections
02Clinical notesANTIMICROBIAL REGIMEN SELECTIONKatie B.Infectious Disease· 7 pagesThis chapter provides a systematic approach to the selection and evaluation of antimicrobial regimens, including the distinction between empiric and definitive therapies.Regimen selection
03Lecture slidesAntibiogram CMEKawempe National Referral HospitalInfectious Diseases· 2024· 15 pagesAn educational presentation explaining the clinical utility of antibiograms, distinguishing colonization from infection, and detailing key resistance mechanisms like MRSA, ESBL, and CPE based on data from Kawempe National Referral Hospital.Reading an antibiogram
04Clinical reviewsGlobal Antibiotic Resistance Surveillance Report 2025: SummaryWorld Health OrganizationInfectious Diseases· 2025· 20 pagesThis WHO report summarizes global antimicrobial resistance and use data for 2025, highlighting rising resistance rates, especially among Gram‑negative bacteria, and persistent surveillance gaps in low‑ and middle‑income countries.Read: Antibiotic resistance · pp. 13–14WHO global resistance report
05Clinical reviewsAntimicrobial resistance and antimicrobial stewardship a frontline (2)InstituteGeneral Medicine· 2025· 11 pagesThis article explores the critical issues surrounding antimicrobial resistance (AMR) and antimicrobial stewardship (AMS) in sub-Saharan Africa, highlighting the challenges faced in addressing these global health threats.Read: pp. 8–9Stewardship frontline
06Clinical reviewsAntibiotic resistance in select RRHs in UgandaInfectious Diseases Institute, Makerere University College of Health Sciences; Ministry of Health; Regional Referral Hospital; Department of Microbiology, Mbarara University of Science and TechnologyGeneral Medicine· 2024· 19 pagesThis study evaluates the burden of antimicrobial resistance (AMR) in selected tertiary hospitals in Uganda using routine surveillance data collected from October 2020 to March 2023. It highlights significant trends in antibiotic susceptibility among various pathogens.Read: Discussion · p. 16Resistance in Ugandan RRHs
07Clinical reviewsANTIBIOTIC MYTHS FOR THE INFECTIOUS DISEASES CLINICIANUniversity of Pittsburgh School of Medicine; Duke University Medical Center; Temple UniversityInfectious Diseases· 2023· 13 pagesThis document addresses common misconceptions regarding the use of antimicrobials, particularly focusing on the nuanced considerations for various antibiotics as understood by infectious diseases specialists.Antibiotic myths
08Clinical reviewsWHEN ORAL THERAPY CAN REPLACE INTRAVENOUS ANTIBIOTICS—CHANGING PRACTICE AS NEW DATA EMERGELos Angeles County and University of Southern California (LAC+USC) Medical CenterInfectious Disease· 2023· 2 pagesThis document discusses the evolving practice of using oral antibiotics instead of intravenous therapy for treating certain infections, supported by recent clinical trial data.When oral can replace IV
09Clinical reviewsDURATION OF ANTIBIOTIC THERAPY: WITH OR WITHOUT BIOMARKERS?Department of Critical Care Medicine, Hospital de São Francisco Xavier, Unidade Local de Saúde de Lisboa Ocidental, Lisbon, Portugal; NOVA Medical School, Comprehensive Health Research Centre, NOVA University of Lisbon, Lisbon, Portugal; Center forCritical Care Medicine· 11 pagesThis document discusses the rising issue of antibiotic overuse and its correlation with multidrug-resistant pathogens, emphasizing the need for evidence-based antibiotic prescribing practices in critically ill patients.Duration of therapy & biomarkers
10Guidelines & protocolsINFECTIOUS DISEASES SOCIETY OF AMERICA GUIDANCE ON THE TREATMENT OF EXTENDED-SPECTRUM β-LACTAMASE PRODUCING ENTEROBACTERALES (ESBL-E), CARBAPENEM-RESISTANT ENTEROBACTERALES (CRE), AND PSEUDOMONAS AERUGINOSA WITH DIFFICULT-TO-TREAT RESISTANCE (DTR- P.Johns Hopkins University School of Medicine, The University of Texas MD Anderson Cancer Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, University Hospitals Cleveland Medical Center, University of Virginia, University ofInfectious Disease· 8 pagesThis guidance document provides recommendations for the treatment of infections caused by extended-spectrum β-lactamase–producing Enterobacterales (ESBL-E), carbapenem-resistant Enterobacterales (CRE), and Pseudomonas aeruginosa with difficult-to-treat resistance.IDSA ESBL guidance
11Guidelines & protocolsINTERNATIONAL CONSENSUS GUIDELINES FOR THE OPTIMAL USE OF THE POLYMYXINSSchool of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York; Detroit Medical Center; Department of Internal Medicine, Medical School, Universidade Federal do Rio Grande do Sul; Infectious Diseases Institute, RambamInfectious Diseases· 2019· 30 pagesThis article presents the international consensus guidelines for the optimal use of polymyxins, endorsed by several professional societies in clinical pharmacy and infectious diseases.Polymyxins consensus
12Clinical toolsAPPROACH TO THE PATIENT WITH A PAST PENICILLIN REACTION WHO REQUIRES ANTIBIOTICSAllergy and Immunology· 1 pagesThis algorithm provides guidance for managing patients with a history of penicillin allergy who require antibiotic treatment, focusing on both hospitalized and outpatient settings.Penicillin-allergy workarounds

Collection updated Sep 2026· Access follows each resource's usual availability.

Resources in this collection