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Clinical reviews
TIRZEPATIDE AND PREVENTION OF CHRONIC KIDNEY DISEASE
Instituto Universitario CEMIC, Buenos Aires, Argentina; Department of Nephrology and Hypertension, IIS-Fundacion Jimenez Diaz UAM, Madrid, Spain; Vall d’Hebron University Hospital, Vall d’Hebron Institute of Research, Barcelona, Spain; Universidad
·
Nephrology
· 12 pages
This document reviews the effects of tirzepatide, a dual agonist for GIP and GLP-1 receptors, on chronic kidney disease (CKD) and cardiovascular risk factors in patients with type 2 diabetes mellitus (T2DM). It highlights recent clinical trials demonstrating its potential benefits in reducing albuminuria and improving kidney outcomes.
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Clinical reviews
HORMONES AND AGING: AN ENDOCRINE SOCIETY SCIENTIFIC STATEMENT
Perelman School of Medicine at the University of Pennsylvania, University of Michigan, Johns Hopkins University School of Medicine, Oregon Osteoporosis Center, University of Virginia
·
Endocrinology
· 2023
· 40 pages
This scientific statement discusses the hormonal changes associated with aging and their implications for health and disease management in older adults.
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Clinical reviews
CURRENT AND EMERGING THERAPEUTIC APPROACHES FOR VASCULAR COGNITIVE IMPAIRMENT AND DEMENTIA
Louise S. Goodall, MBBS (Hons), MMED (CLIN Epi), Matthew J. Lennon, MD, PhD, Perminder S. Sachdev, MBBS, MD, PhD, Philip B. Gorelick, MD, MPH, Jason C. Kovacic, MBBS, PhD, Katherine Samaras, MBBS, PhD
·
Neurology
· 24 pages
This document reviews advances and new perspectives on the management and prevention of vascular cognitive impairment and dementia (VCID), highlighting the role of cognitive enhancers and behavioral interventions.
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Clinical reviews
SEQUENCING OF MEDICAL THERAPY IN HEART FAILURE WITH A REDUCED EJECTION FRACTION
Essex Cardiothoracic Centre, Basildon, UK; Anglia Ruskin University Faculty of Health Education Medicine & Social Care, Chelmsford, UK
·
Cardiology
· 2022
· 8 pages
This document discusses the management of heart failure with reduced ejection fraction, emphasizing the importance of timely and appropriate medical therapy to improve patient outcomes.
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Clinical reviews
MYCETOMA: A UNIQUE NEGLECTED TROPICAL DISEASE
Rotterdam Centre for Tropical Medicine, Erasmus MC, University of Rotterdam, University Hospital, Universidad Autonoma de Nuevo Leon, Mycetoma Research Center, University of Khartoum, University of Newcastle
·
Infectious Diseases
· 2016
· 13 pages
Mycetoma is an infection of subcutaneous tissues caused by bacteria or fungi, typically affecting poor communities in remote areas. It results in mass and sinus formation, with a discharge containing grains.
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Clinical reviews
INTERSTITIAL LUNG DISEASES
Marlies Wijsenbeek, Atsushi Suzuki, Toby M Maher
·
Pulmonology
· 2022
· 18 pages
This Seminar provides an update on epidemiology, pathogenesis, presentation, diagnosis, disease course, and management of the interstitial lung diseases that are most frequently encountered in clinical practice.
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Clinical reviews
CLASSIC HODGKIN LYMPHOMA
Kishan K. Patel, MD, MHS; Alison J. Moskowitz, MD
·
Hematology/Oncology
· 2026
· 14 pages
This document provides a comprehensive review of Classic Hodgkin Lymphoma (cHL), detailing its epidemiology, clinical presentation, and management strategies.
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Clinical reviews
VENOUS DOPPLER TO ASSESS CONGESTION: A COMPREHENSIVE REVIEW OF CURRENT EVIDENCE AND NOMENCLATURE
Centre Hospitalier de l’Université de Montréal, Montreal Heart Institute, University Hospital Basel, Monash University, Royal Melbourne Hospital
·
Intensive Care
· 2022
· 15 pages
This document provides a comprehensive review of the current evidence and nomenclature related to the use of venous Doppler ultrasound in assessing organ congestion due to venous hypertension.
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Clinical reviews
DIAGNOSTIC ACCURACY OF CHEST X-RAY SCREENING FOR SILICOSIS: A SYSTEMATIC REVIEW, META-ANALYSIS AND MODELLING STUDY
Imperial College London, Royal Brompton and Harefield Hospitals
·
Pulmonology
· 2024
· 7 pages
This document presents a systematic review and meta-analysis evaluating the diagnostic accuracy of chest X-ray (CXR) screening for silicosis compared to other methods such as high-resolution CT (HRCT) and autopsy.
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Clinical reviews
INTRACORONARY IMAGING IN PERCUTANEOUS CORONARY INTERVENTION: WHY, WHEN, HOW AND WHICH FROM LARGE, RANDOMIZED TRIALS
Department of Cardiology
·
Cardiology
· 2026
· 20 pages
This document reviews the role of intracoronary imaging (ICI) in percutaneous coronary intervention (PCI), discussing its benefits, optimal use cases, and the evidence from large randomized trials.
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Clinical reviews
PATIENT BLOOD MANAGEMENT IN OBSTETRICS AND GYNECOLOGY: A GLOBAL SCOPING REVIEW OF STRATEGIES ACROSS DIFFERENT INCOME COUNTRIES
Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Mohandai Oswal Hospital, Ludhiana, India; AIIMS, Nagpur, India; Mahatma Gandhi Medical College and Hospital, Jaipur, India; Post Graduate Institute of Medical Education and Research,
·
Obstetrics and Gynecology
· 2026
· 27 pages
This review article discusses the various strategies for patient blood management (PBM) in obstetrics and gynecology across different income countries, focusing on the impact of resources on healthcare quality.
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Clinical reviews
ACUTE CORONARY SYNDROMES: STATE-OF-THE-ART DIAGNOSIS, MANAGEMENT, AND SECONDARY PREVENTION
Department of Cardiology, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Trust Foundation, London, UK; Department of Cardiology, Milton Keynes University Hospital, UK; Department of Cardiology, Heart Centre Cologne, Faculty of Medicine
·
Cardiology
· 2024
· 26 pages
This state-of-the-art review synthesizes advances in the diagnosis, management, and secondary prevention of acute coronary syndromes (ACS) from 2023 to 2025.
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Clinical reviews
HEART–LUNG INTERACTIONS IN COMBINED DISTRIBUTIVE SHOCK AND ARDS: APPLIED CARDIOPULMONARY PHYSIOLOGY AT THE BEDSIDE
Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania; OUTCOMES RESEARCH Consortium; Department of Critical Care Medicine, Tzaneio General Hospital; Department of Cardiology, Sismanogleio General
·
Critical Care Medicine
· 32 pages
This review synthesizes current mechanistic insights into heart–lung interactions in distributive shock with ARDS, highlighting the central role of right ventricular–pulmonary arterial coupling and the dual impact of altered lung mechanics and vascular dysregulation.
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Clinical reviews
SEPSIS IN END-STAGE LIVER DISEASE AND ACUTE-ON-CHRONIC LIVER FAILURE: PATHOPHYSIOLOGY, DIAGNOSTIC CHALLENGES, AND PHARMACOLOGICAL MANAGEMENT
Transplant Anesthesia and Intensive Care Unit, University of Pisa, Italy
·
Infectious Diseases
· 2026
· 13 pages
This review synthesizes current evidence on the epidemiology, immunopathophysiology, microbiology, diagnostic strategies, and therapeutic management of sepsis in patients with end-stage liver disease (ESLD) and acute-on-chronic liver failure (ACLF).
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Clinical reviews
THE MANAGEMENT OF DIABETES MELLITUS USING MEDICINAL PLANTS AND VITAMINS
Florida Agricultural and Mechanical University, Alcorn State University, Jackson State University, Morehouse School of Medicine, Howard University, Morgan State University
·
Endocrinology
· 14 pages
This document reviews the management of diabetes mellitus through the use of medicinal plants and vitamins, highlighting their potential benefits and mechanisms of action.
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Clinical reviews
TREATMENT AND MONITORING
Justin W. Yan, MD, MSc; Nathan L. Haas, MD
·
Emergency Medicine
· 2026
· 7 pages
This document provides a comprehensive overview of the management and monitoring of diabetic ketoacidosis (DKA), an acute complication of diabetes mellitus. It discusses the clinical presentation, assessment, and treatment protocols necessary for effective management.
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Clinical reviews
MULTIDRUG-RESISTANT TUBERCULOSIS: A COMPREHENSIVE REVIEW OF PATHOGENESIS, DRUG RESISTANCE, CURRENT TREATMENT AND FUTURE PROSPECTS
Sharda School of Bioscience and Technology, Sharda University, Greater Noida, Uttar Pradesh, India
·
Infectious Disease
· 2026
· 27 pages
This comprehensive review introduces the mechanisms of bacterial pathogenesis against the human defence system and the development of drugs against Mycobacterium tuberculosis, with a focus on drug resistance and mutations.
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Clinical reviews
PHYSIOLOGIC PACING IN HEART FAILURE
Mihail G. Chelu, M.D., Ph.D., Jeanne E. Poole, M.D., Kenneth A. Ellenbogen, M.D.
·
Cardiology
· 15 pages
This review article discusses cardiac physiologic pacing, also known as cardiac resynchronization therapy, and its indications for patients with heart failure and reduced left ventricular ejection fraction. It highlights the benefits of biventricular pacing and emerging alternatives such as His bundle and left bundle branch pacing.
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Clinical reviews
INCLUSION BODY MYOSITIS: CLINICAL FEATURES AND PATHOGENESIS
Steven A. Greenberg
·
Neurology
· 16 pages
Inclusion body myositis (IBM) is often viewed as an enigmatic disease with uncertain pathogenic mechanisms and confusion around diagnosis, classification and prospects for treatment. Its clinical features and pathological features are unique among muscle diseases.
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Clinical reviews
CURRENT THERAPEUTIC LANDSCAPE AND FUTURE TREATMENT PERSPECTIVES OF MASH
Suchira Gallage, Olivier Govaere, Quentin M. Anstee, Gerald I. Shulman, Frank Tacke, Mathias Heikenwalder
·
Hepatology
· 2026
· 16 pages
This document discusses the progressive form of metabolic dysfunction-associated steatotic liver disease (MASH), highlighting recent advancements in therapeutic options and the need for stratified treatment approaches.
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Clinical reviews
PRIMER CROHN’S DISEASE
Giulia Roda, Siew Chien Ng, Paulo Gustavo Kotze, Marjorie Argollo, Remo Panaccione, Antonino Spinelli, Arthur Kaser, Laurent Peyrin-Biroulet, Silvio Danese
·
Gastroenterology
· 2020
· 19 pages
This document provides a comprehensive overview of Crohn's disease, an inflammatory bowel disease characterized by chronic inflammation of the gastrointestinal tract. It discusses the disease's epidemiology, pathophysiology, diagnosis, and management strategies.
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Clinical reviews
Managing Diabetic Ketoacidosis
American College of Emergency Physicians
·
Emergency Medicine
· 2026
· 7 pages
This document provides a comprehensive overview of diabetic ketoacidosis (DKA), including its metabolic derangements, assessment, and management strategies. It emphasizes the importance of recognizing and addressing the recurrent nature of DKA in high-risk patients.
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Clinical reviews
ADVANCES IN COMBINATION THERAPIES FOR SERIOUS INFECTIONS DUE TO MULTIDRUG-RESISTANT GRAM-NEGATIVE BACILLI
Luca Mezzadri, Abi Manesh, Ya-Ting Chang, Kim Anh Nguyen, David L. Patterson
·
Infectious Disease
· 2026
· 54 pages
This document reviews the current evidence and recommendations for combination therapies targeting serious infections caused by multidrug-resistant gram-negative bacilli.
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Clinical reviews
HYPERTENSION MANAGEMENT IN PATIENTS WITH CARDIOVASCULAR COMORBIDITIES
Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, Saarland University; Université Paris Cité; Brigham and Women’s Hospital; Jichi Medical University; Royal Perth Hospital; University of Milano-Bicocca; National and Kapodistrian
·
Cardiology
· 2022
· 19 pages
This document provides a comprehensive review of hypertension management specifically in patients who have cardiovascular comorbidities.
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