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Clinical reviews
TRICUSPID REGURGITATION: RECENT ADVANCES IN UNDERSTANDING PATHOPHYSIOLOGY, SEVERITY GRADING AND OUTCOME
NewYork-Presbyterian/Columbia University Medical Center; University of Milano-Bicocca; Istituto Auxologico Italiano; Medical University of Vienna; IRCCS Ospedale San Raffaele; University Hospital Ramón y Cajal; Université de Rennes-1
·
Cardiology
· 2022
· 17 pages
This document discusses the recent advancements in understanding tricuspid regurgitation (TR), focusing on its pathophysiology, severity grading, and outcomes associated with the condition.
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Clinical reviews
DIRECT ORAL ANTICOAGULANTS IN PRIMARY AND SECONDARY PREVENTION OF THROMBOTIC EVENTS: 2026 ACC SCIENTIFIC STATEMENT
American College of Cardiology
·
Cardiology
· 2026
· 29 pages
This document provides a comprehensive, evidence-based overview of established and emerging indications for direct oral anticoagulant (DOAC) therapy in the primary and secondary prevention of thrombotic events.
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Clinical reviews
Management of Life-Threatening Asthma
CHEST
·
Pulmonology
· 2022
· 10 pages
This document outlines strategies for the assessment and management of patients with acute life-threatening asthma, particularly those requiring admission to the ICU.
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Clinical reviews
UNDERSTANDING THE SPECTRAL DOPPLER WAVEFORM OF THE HEPATIC VEINS IN HEALTH AND DISEASE
Meir H. Scheinfeld, MD, PhD; Ardiana Bilali, ARDMS; Mordecai Koenigsberg, MD
·
Radiology
· 2009
· 19 pages
This document provides an in-depth analysis of the spectral Doppler waveform of the hepatic veins, highlighting its importance in assessing cardiac and hepatic physiology.
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Clinical reviews
CONTEMPORARY MANAGEMENT OF ACUTE HEART FAILURE
American College of Cardiology Foundation
·
Cardiology
· 2026
· 19 pages
This document provides an updated and practical synthesis of the management of acute heart failure (AHF), covering aspects from early diagnostic assessment to long-term remission strategies.
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Clinical reviews
IVUS, OCT, or Angiography as Guidance for PCI in Complex Coronary Artery Lesions
Pedro E.P. Carvalho, MD, Vanio L.J. Antunes, Vinicius Bittar de Pontes, Wilton Francisco Gomes, MD, Beatriz Polachini Assunes Goncalves, Adriano Caixeta, MD, PhD, Dimitrios Strepkos, MD, Michaella Alexandrou, MD, Deniz Mutlu, MD, C. Michael Gibson, MD,
·
Cardiology
· 13 pages
This study assesses the impact of intravascular ultrasound (IVUS) and optical coherence tomography (OCT) guidance on reducing major adverse cardiovascular events (MACE) compared to angiography-guided PCI in patients with complex coronary artery lesions.
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Clinical reviews
ROLE OF GLUCAGON-LIKE PEPTIDE-1 RECEPTOR AGONISTS IN ACHIEVING WEIGHT LOSS AND IMPROVING CARDIOVASCULAR OUTCOMES IN PEOPLE WITH OVERWEIGHT AND OBESITY
Erin D. Michos, MD, MHS; Francisco Lopez-Jimenez, MD, MSc, MBA; Martha Gulati, MD, MS
·
Endocrinology
· 2023
· 14 pages
This contemporary review discusses the role of glucagon-like peptide-1 receptor agonists in managing obesity and reducing cardiovascular disease risk. It highlights the efficacy and safety of these medications in the context of obesity treatment.
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Clinical reviews
MULTIMODALITY IMAGING IN HYPERTROPHIC CARDIOMYOPATHY
Jihoon Kim and Sang-Chol Lee
·
Cardiology
· 10 pages
This review discusses the importance of a multimodality imaging approach in the diagnosis and management of hypertrophic cardiomyopathy (HCM), highlighting the strengths and limitations of various imaging modalities.
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Clinical reviews
DIFFERENT CONCENTRATIONS OF ALBUMIN VERSUS CRYSTALLOID IN PATIENTS WITH SEPSIS AND SEPTIC SHOCK: A META-ANALYSIS OF RANDOMIZED CLINICAL TRIALS
Wuxi School of Medicine, Jiangnan University
·
Intensive Care Medicine
· 2023
· 11 pages
This meta-analysis evaluates the efficacy of different concentrations of albumin compared to crystalloid fluids in reducing mortality rates in patients with sepsis and septic shock. The study synthesizes data from multiple randomized controlled trials to provide insights into optimal resuscitation strategies.
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Clinical reviews
Management of Life-Threatening Asthma
CHEST
·
Pulmonology
· 2022
· 10 pages
This document outlines strategies for the assessment and management of patients with acute life-threatening asthma, particularly those requiring admission to the ICU.
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Clinical reviews
A COMPREHENSIVE REVIEW OF ACUTE CARDIO-RENAL SYNDROME: NEED FOR NOVEL BIOMARKERS
Indian Institute of Technology (IIT)-Mandi, Postgraduate Institute of Medical Education and Research
·
Nephrology
· 2023
· 19 pages
This document provides an extensive review of acute cardio-renal syndrome, focusing on the need for novel biomarkers to improve diagnosis and management.
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Clinical reviews
GREAT DEBATE: THE UNIVERSAL DEFINITION OF MYOCARDIAL INFARCTION IS FLAWED AND SHOULD BE PUT TO REST
Cardiovascular Research Institute Basel, University Hospital Basel, Health New Zealand, National Heart and Lung Institute, St. George's, University of London
·
Cardiology
· 15 pages
This document discusses the flaws in the universal definition of myocardial infarction (MI) and argues for its reevaluation. It highlights the clinical and pathological aspects of MI and the implications for diagnosis and classification.
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Clinical reviews
CAUSES AND CONSEQUENCES OF DISCONTINUATION OF GLP1RAS OR TIRZEPATIDE
Polo Scientifico e Tecnologico, IRCCS MultiMedica, Milan, Italy; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy; Department of Endocrinology and Metabolic Diseases, IRCCS MultiMedica, Milan, Italy; Department of
·
Endocrinology
· 2026
· 13 pages
This review discusses the reasons for discontinuation of GLP1 receptor agonists and tirzepatide in the management of type 2 diabetes mellitus and obesity, highlighting the consequences of such discontinuation on cardiometabolic health.
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Clinical reviews
PERINATAL OUTCOMES IN EARLY AND LATE GESTATIONAL DIABETES MELLITUS AFTER TREATMENT FROM 24–28 WEEKS' GESTATION: A TOBOGM SECONDARY ANALYSIS
TOBOGM Research Group
·
Endocrinology
· 2024
· 11 pages
This study analyzes perinatal outcomes in pregnant women with early and late gestational diabetes mellitus (GDM) after treatment initiated between 24-28 weeks' gestation. It highlights the differences in outcomes based on the timing of GDM diagnosis and treatment.
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Clinical reviews
WIDE COMPLEX TACHYCARDIA: DIFFERENTIATING VENTRICULAR TACHYCARDIA FROM SUPRAVENTRICULAR TACHYCARDIA
Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, UK
·
Cardiology
· 2021
· 9 pages
This document discusses the differentiation between ventricular tachycardia (VT) and supraventricular tachycardia (SVT) in the context of wide QRS complex tachycardia (WCT). It emphasizes the importance of accurate diagnosis for treatment urgency and risk stratification.
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Clinical reviews
TUMOUR LYSIS SYNDROME
Scott C. Howard, Anna Avagyan, Biruh Workeneh, Ching-Hon Pui
·
Oncology
· 2024
· 17 pages
Tumour lysis syndrome (TLS) represents a critical oncological emergency characterized by extensive tumour cell breakdown, leading to the swift release of intracellular contents into the systemic circulation, which can result in severe metabolic imbalances.
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Clinical reviews
Management of Bacterial and Fungal Infections in the ICU: Diagnosis, Treatment, and Prevention Recommendations
Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Hammersmith Hospital; Centre for Antimicrobial Optimisation, Imperial College London; David Price Evan’s Group in Infectious Diseases and Global Health,
·
Intensive Care Medicine
· 2023
· 18 pages
This document reviews the epidemiology, diagnosis, treatment, and prevention of bacterial and fungal infections in the intensive care unit (ICU). It highlights the challenges posed by drug-resistant organisms and the impact of infections on patient outcomes.
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Clinical reviews
PRIMER Hypothyroidism
Layal Chaker, Salman Razvi, Isabela M. Bensenor, Fereidoun Azizi, Elizabeth N. Pearce, Robin P. Peeters
·
Endocrinology
· 2022
· 17 pages
This document provides a comprehensive overview of hypothyroidism, a common clinical condition characterized by thyroid hormone deficiency. It discusses the classification, causes, symptoms, and treatment options for hypothyroidism.
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Clinical reviews
PRIMER Ulcerative colitis
Taku Kobayashi, Britta Siegmund, Catherine Le Berre, Shu Chen Wei, Marc Ferrante, Bo Shen, Charles N. Bernstein, Silvio Danese, Laurent Peyrin-Biroulet, Toshifumi Hibi
·
Gastroenterology
· 2020
· 20 pages
This document provides a comprehensive overview of ulcerative colitis (UC), a chronic inflammatory bowel disease, discussing its pathogenesis, treatment advancements, and the impact on patient quality of life.
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Clinical reviews
INTRAVENOUS FLUIDS IN CRITICALLY ILL PATIENTS: WHEN LESS IS BETTER
Hospital General San Juan del Río Querétaro, Mexico
·
Intensive Care
· 7 pages
This document discusses the role of intravenous fluids in the management of critically ill patients, emphasizing the potential risks of aggressive fluid therapy.
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Clinical reviews
EFFICIENCY OF HYPERTONIC SALINE IN THE MANAGEMENT OF DECOMPENSATED HEART FAILURE: A SYSTEMATIC REVIEW AND META‑ANALYSIS OF CLINICAL STUDIES
Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania; Koc University School of Medicine, Istanbul, Turkey; Cardiovascular Diseases Institute, Iasi, Romania; Suleyman Demirel University School of Medicine, Isparta, Turkey
·
Cardiology
· 2020
· 17 pages
This systematic review evaluates the efficiency of hypertonic saline combined with furosemide in managing acute decompensated heart failure (ADHF). It aims to assess the impact on mortality, readmissions, kidney function, and other clinical outcomes.
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Clinical reviews
PHENOTYPING THE HYPERTENSIVE HEART
Klinik für Innere Medizin II, Universitätsklinikum Ulm; Department of Medicine and Surgery, University of Milano-Bicocca; Baker Heart and Diabetes Institute; Baker Department of Cardiometabolic Health, University of Melbourne
·
Cardiology
· 2022
· 17 pages
This document discusses the role of echocardiography and other imaging techniques in evaluating cardiac damage in hypertensive patients. It highlights the importance of identifying left ventricular dysfunction and other pathologic processes in managing hypertension.
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Clinical reviews
GUILLAIN–BARRÉ SYNDROME
Sonja E. Leonhard, Nowshin Papri, Luis Querol, Simon Rinaldi, Nortina Shahrizaila, Bart C. Jacobs
·
Neurology
· 2024
· 19 pages
Guillain–Barré syndrome (GBS) is a rare immune-mediated polyneuropathy characterized by rapidly progressive weakness and sensory deficits that can lead to complete paralysis. The document discusses the diagnosis, management, and challenges associated with GBS.
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Clinical reviews
PULSED FIELD ABLATION VS STANDARD RADIOFREQUENCY ABLATION FOR TYPICAL ATRIAL FLUTTER
Dr. Stanislav
·
Cardiology
· 15 pages
This document compares pulsed field ablation (PFA) and standard radiofrequency ablation (RFA) for treating typical atrial flutter, focusing on lesion characteristics and efficacy.
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