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William J. Calhoun and Geoffrey L. Chupp
Severe asthma, affecting a small percentage of patients, leads to significant healthcare resource use. The Global Initiative for Asthma (GINA) provides guidelines for managing asthma, recommending inhaled corticosteroids and long-acting beta-agonists, with biologics as potential add-ons. This review evaluates recent advancements in asthma treatment, including the role of biologics and small-molecule drugs, and proposes an algorithm for managing severe asthma based on GINA recommendations. The future of asthma treatment may increasingly rely on personalized approaches informed by biomarkers.
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