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Clinical reviews
PERIOPERATIVE CHEMOTHERAPY WITH FLUOROURACIL PLUS LEUCOVORIN, OXALIPLATIN, AND DOCETAXEL VERSUS FLUOROURACIL OR CAPECITABINE PLUS CISPLATIN AND EPIRUBICIN FOR LOCALLY ADVANCED, RESECTABLE GASTRIC OR GASTRO-OESOPHAGEAL JUNCTION ADENOCARCINOMA (FLOT4): A
German Cancer Consortium
PDF202310 pages482 KB
The trial involved 716 patients with histologically-confirmed advanced clinical stage cT2 or higher or nodal positive stage, randomly assigned to receive either the FLOT regimen or a control regimen. The study aimed to evaluate the pathological response and overall survival outcomes associated with the different chemotherapy regimens. Results indicated significant findings regarding treatment efficacy and safety, contributing to the understanding of perioperative chemotherapy in this patient population.
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