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THE ASSOCIATION BETWEEN DUAL RAAS INHIBITION AND RISK OF ACUTE KIDNEY INJURY AND HYPERKALEMIA IN PATIENTS WITH DIABETIC KIDNEY DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS
Chronic Disease Innovation Centre, Seven Oaks General Hospital; Department of Community Health Sciences, Faculty of Science, University of Manitoba; Department of Internal Medicine, Max Rady College of Medicine, University of Manitoba; Neil John Mclean
PDF32 pages4.2 MB
The document provides a comprehensive analysis of 31 trials involving 33,048 patients with diabetic kidney disease, focusing on the comparative risks of AKI and hyperkalemia when using dual RAAS inhibitors versus single agents. It highlights significant findings regarding the differential risks associated with steroidal and non-steroidal mineralocorticoid receptor antagonists (MRAs). The authors suggest that further research is needed to explore these risks in real-world clinical settings.
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