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Clinical reviews
CONTEMPORARY APPROACHES TO KIDNEY DYSFUNCTION AND DIURETIC RESISTANCE IN ACUTE DECOMPENSATED HEART FAILURE
Yale University
PDF20263.6 MB
Kidney dysfunction, defined by reduced estimated glomerular filtration rate (eGFR) or inadequate urinary response to diuretics, is a significant risk factor for mortality in acute decompensated heart failure (ADHF). The document explores various mechanisms contributing to kidney dysfunction, including hemodynamic factors like low cardiac output and venous congestion, as well as neurohormonal activation and inflammation. It emphasizes the challenges in managing diuretic resistance and the need for tailored therapeutic strategies to improve patient outcomes.
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