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Resources
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Clinical reviews
METABOLIC ACIDOSIS IN PATIENTS WITH CKD: EPIDEMIOLOGY, PATHOGENESIS
Medical University of Silesia in Katowice
·
Nephrology
· 2021
· 16 pages
This review article summarizes the current knowledge concerning the epidemiology, pathogenesis, diagnosis, treatment, and prevention of metabolic acidosis in patients with chronic kidney disease (CKD).
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Clinical reviews
PREHOSPITAL TRANEXAMIC ACID FOR SEVERE TRAUMA
The PATCH-Trauma Investigators and the ANZICS Clinical Trials Group
·
Trauma Surgery
· 2023
· 10 pages
This article investigates whether prehospital administration of tranexamic acid improves survival outcomes in patients with major trauma and suspected trauma-induced coagulopathy.
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Clinical reviews
NO BLOOD TRANSFUSION FOR MY OWN ANAEMIA—TIT FOR TAT?
University Hospital Regensburg, Germany
·
Anaesthesiology
· 2023
· 2 pages
This document reflects on the author's personal experiences with anemia and the decision-making process regarding blood transfusions in critically ill patients. It discusses the balance of benefits and risks associated with transfusions from both a clinical and personal perspective.
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Clinical reviews
A REVIEW OF CURRENT KEY GUIDELINES FOR MANAGING HIGH RISK PATIENTS WITH DIABETES AND HEART FAILURE
School of Cardiovascular and Metabolic Health, BHF Glasgow Cardiovascular Research Centre, University of Glasgow
·
Cardiology
· 23 pages
This document reviews recent guidelines on the management of heart failure in patients with diabetes, focusing on major recommendations from European and USA society guidelines.
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Clinical reviews
RENIN-ANGIOTENSIN INHIBITION AND OUTCOMES IN HFrEF AND ADVANCED KIDNEY DISEASE
The American Journal of Medicine
·
Cardiology
· 2023
· 24 pages
This article investigates the effects of renin-angiotensin system inhibition on clinical outcomes in patients with heart failure with reduced ejection fraction (HFrEF) and advanced kidney disease.
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Clinical reviews
UPDATE ON MALARIA
ISGlobal, Hospital Clínic, Universitat de Barcelona; Centro de Investigação em Saúde de Manhiça; Ifakara Health Institute; Universidad de Navarra; Hospital Sant Joan de Deu
·
Infectious Diseases
· 2020
· 8 pages
This document provides a comprehensive review of the current state of malaria, including its diagnosis, treatment options, and the challenges posed by drug resistance and vaccine development.
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Clinical reviews
SUBCLINICAL LEAFLET THROMBOSIS AND ANTICOAGULATION AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT
New York–Presbyterian Hospital/Columbia University Irving Medical Center
·
Cardiology
· 2022
· 7 pages
This review discusses the prevalence and management of subclinical leaflet thrombosis in patients after transcatheter aortic valve replacement (TAVR), highlighting the role of oral anticoagulation.
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Clinical reviews
Combination of GM CSF and carbapenem is superior to carbapenem monotherapy in difficult- to- treat spontaneous bacterial peritonitis: A randomized controlled trial
Institute of Liver and Biliary Sciences, New Delhi, India
·
Hepatology
· 2023
· 9 pages
This study investigates the efficacy of combining GM-CSF with carbapenem compared to carbapenem alone in treating difficult-to-treat spontaneous bacterial peritonitis in cirrhotic patients.
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Clinical reviews
EFFECTS OF BLOOD PRESSURE AND TRANEXAMIC ACID IN SPONTANEOUS INTRACEREBRAL HAEMORRHAGE: A SECONDARY ANALYSIS OF A LARGE RANDOMISED CONTROLLED TRIAL
Jason Philip Appleton, Zhe Kang Law, Lisa Jane Woodhouse, Rustam Al-Shahi Salman, Maia Beridze, Hanne Christensen, Robert A Dineen, Juan José Egea Guerrero, Timothy J England, Michal Karlinski, Kailash Krishnan, Ann Charlotte Laska, Philippe Lyrer,
·
Neurology
· 2023
· 10 pages
This study investigates the interaction between baseline systolic blood pressure and the effect of tranexamic acid on functional outcomes in patients with spontaneous intracerebral hemorrhage.
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Clinical notes
THE NEUROLOGIC EXAM
Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School
·
Neurology
· 2023
· 7 pages
This document provides a comprehensive overview of the neurologic examination, emphasizing its historical significance and current relevance in clinical practice. It discusses various reflexes and their implications in diagnosing neurological conditions.
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Clinical reviews
PULMONARY HYPERTENSION ASSOCIATED WITH LEFT HEART DISEASE
Clinic III for Internal Medicine (Dept. of Cardiology, Pulmonology, and Intensive Care Medicine), Cologne Cardiovascular Research Center (CCRC), Heart Center at the University Hospital Cologne, Center for Molecular Medicine Cologne (CMMC), Faculty of
·
Cardiology
· 2023
· 8 pages
This document reviews the complexities of pulmonary hypertension (PH) in patients with left heart disease (LHD), focusing on updated hemodynamic definitions and management strategies.
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Clinical reviews
TREATMENT OF GESTATIONAL DIABETES MELLITUS DIAGNOSED EARLY IN PREGNANCY
D. Simmons, J. Immanuel, W.M. Hague, H. Teede, C.J. Nolan, M.J. Peek, J.R. Flack, M. McLean, V. Wong, E. Hibbert, A. Kautzky-Willer, J. Harreiter, H. Backman, E. Gianatti, A. Sweeting, V. Mohan, J. Enticott, N.W. Cheung
·
Obstetrics and Gynecology
· 2023
· 13 pages
This original article investigates whether early treatment of gestational diabetes mellitus (GDM) diagnosed before 20 weeks of gestation can improve maternal and infant health outcomes.
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Clinical reviews
DEXAMETHASONE VERSUS SURGERY FOR CHRONIC SUBDURAL HEMATOMA
Amphia Hospital, Leiden University Medical Center, Haaglanden Medical Center, Erasmus Medical Center, University of Groningen, Isala, Medisch Spectrum Twente, University of Twente
·
Neurosurgery
· 2023
· 11 pages
This article compares the efficacy of dexamethasone treatment versus surgical intervention for patients with chronic subdural hematoma.
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Clinical reviews
EFFECTIVENESS OF SPIRONOLACTONE FOR WOMEN WITH ACNE VULGARIS
BMJ
·
Dermatology
· 2023
· 10 pages
This document assesses the effectiveness of oral spironolactone for treating acne vulgaris in adult women through a pragmatic, multicentre, phase 3, double-blind, randomized controlled trial.
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Guidelines & protocols
SOCIETY FOR OBSTETRIC ANESTHESIA AND PERINATOLOGY: CONSENSUS STATEMENT AND RECOMMENDATIONS FOR ENHANCED RECOVERY AFTER CESAREAN
Society for Obstetric Anesthesia and Perinatology
·
Obstetrics
· 2021
· 16 pages
This article provides a summary of the Enhanced Recovery After Cesarean delivery (ERAC) protocol developed by the Society for Obstetric Anesthesia and Perinatology (SOAP). It outlines practical and evidence-based recommendations aimed at optimizing maternal recovery and perioperative outcomes after cesarean delivery.
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Clinical reviews
Neonatal Seizures
Montefiore Medical Center, Albert Einstein College of Medicine
·
Pediatrics
· 2023
· 9 pages
Neonatal seizures are defined as seizures occurring within 4 weeks after birth in full-term infants or within 44 weeks of postmenstrual age in preterm infants. The article discusses their incidence, classification, and common causes such as metabolic disturbances, infections, and cerebral lesions.
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Clinical reviews
THE UTILITY OF INVASIVE HEMODYNAMICS IN THE MANAGEMENT OF CARDIOGENIC SHOCK
Western University, London Health Sciences Centre, London, Ontario, Canada
·
Cardiology
· 2023
· 3 pages
This article discusses the role of pulmonary artery catheters (PACs) in the management of cardiogenic shock, highlighting their potential benefits and the variability of their use in Canada.
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Clinical reviews
CENTRAL VENOUS PRESSURE (CVP)
Olfa Hamzaoui and Jean-Louis Teboul
·
Critical Care
· 2022
· 3 pages
This article discusses the significance of central venous pressure (CVP) in assessing hemodynamic status and guiding fluid therapy in critically ill patients. It emphasizes the importance of accurate measurement techniques and the implications of CVP on organ perfusion.
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Clinical reviews
Early versus Later Anticoagulation for Stroke with Atrial Fibrillation
U. Fischer, M. Koga, D. Strbian, M. Branca, S. Abend, S. Trelle, M. Paciaroni, G. Thomalla, P. Michel, K. Nedeltchev, L.H. Bonati, G. Ntaios, T. Gattringer, E.-C. Sandset, P. Kelly, R. Lemmens, P.N. Sylaja, D. Aguiar de Sousa, N.M. Bornstein, Z.
·
Neurology
· 11 pages
This article investigates the effect of early versus later initiation of direct oral anticoagulants (DOACs) in patients with atrial fibrillation who have experienced an acute ischemic stroke. The study performed an investigator-initiated, open-label trial across 103 sites in 15 countries.
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Clinical reviews
SARCOPENIA AND CARDIOVASCULAR DISEASES
Inova Heart and Vascular Institute; Johns Hopkins University School of Medicine; Cleveland Clinic; University of Arizona; University of Connecticut; Weill Cornell Medicine; University of Washington; University of Texas; University of Pittsburgh; Kaiser
·
Cardiology
· 20 pages
This document discusses the relationship between sarcopenia, characterized by the loss of muscle strength and mass, and cardiovascular diseases, highlighting the increased risks associated with these conditions, particularly in older adults.
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Guidelines & protocols
GASTROINTESTINAL BLEEDING PROPHYLAXIS FOR CRITICALLY ILL PATIENTS: A CLINICAL PRACTICE GUIDELINE
BMJ Publishing Group Ltd.
·
Critical Care
· 2020
· 17 pages
This guideline addresses the role of gastrointestinal bleeding prophylaxis in critically ill patients, prompted by a recent large randomized controlled trial.
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Clinical reviews
COMPARATIVE EFFECTIVENESS OF ASPIRIN DOSING IN CARDIOVASCULAR DISEASE
The New England Journal of Medicine
·
Cardiology
· 2021
· 10 pages
This study investigates the appropriate dose of aspirin to lower the risk of death, myocardial infarction, and stroke while minimizing major bleeding in patients with established atherosclerotic cardiovascular disease.
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Guidelines & protocols
PHARMACOLOGIC TREATMENT OF PRIMARY OSTEOPOROSIS OR LOW BONE MASS TO PREVENT FRACTURES IN ADULTS: A LIVING CLINICAL GUIDELINE FROM THE AMERICAN COLLEGE OF PHYSICIANS
American College of Physicians
·
Endocrinology
· 2023
· 18 pages
This guideline updates the 2017 American College of Physicians (ACP) recommendations on pharmacologic treatment of primary osteoporosis or low bone mass to prevent fractures in adults.
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Clinical reviews
EFFICACY AND SAFETY OF SULBACTAM–DURLobactam VERSUS COLISTIN FOR THE TREATMENT OF PATIENTS WITH SERIOUS INFECTIONS CAUSED BY ACINETOBACTER BAUMANNII–CALCOACETICUS COMPLEX: A MULTICENTRE, RANDOMISED, ACTIVE-CONTROLLED, PHASE 3, NON-INFERIORITY CLINICAL
Keith S Kaye, Andrew F Shorr, Richard G Wunderink, Bin Du, Gabrielle E Poirier, Khurram Rana, Alita Miller, Drew Lewis, John O'Donnell, Lan Chen, Harald Reinhart, Subasree Srinivasan, Robin Isaacs, David Altarac
·
Infectious Disease
· 13 pages
This document presents the findings of a phase 3 clinical trial comparing the efficacy and safety of sulbactam–durlobactam versus colistin for treating serious infections caused by carbapenem-resistant Acinetobacter baumannii–calcoaceticus complex.
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