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Resources
24 shown
Clinical reviews
VEXAS SYNDROME IN MYELODYSPLASTIC SYNDROME WITH AUTOIMMUNE DISORDER
Huijun Huang, Wenjun Zhang, Wenyu Cai, Jinqin Liu, Huijun Wang, Tiejun Qin, Zefeng Xu, Bing Li, Shiqiang Qu, Lijuan Pan, Gang Huang, Robert Peter Gale, Zhijian Xiao
·
Hematology
· 5 pages
This letter discusses VEXAS syndrome, a newly-described adult-onset inflammatory syndrome that overlaps with myelodysplastic syndromes (MDS) and autoimmune disorders. It highlights the importance of screening for UBA1 mutations in patients with MDS and autoimmune disorders.
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Clinical reviews
CHRONIC EOSINOPHILIC PNEUMONIA
Talmadge E King, Jr, MD
·
Pulmonology
· 2025
· 23 pages
Chronic eosinophilic pneumonia (CEP) is an idiopathic disorder characterized by an abnormal and marked accumulation of eosinophils in the interstitium and alveolar spaces of the lung. This document reviews the clinical manifestations, diagnosis, and treatment of CEP.
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Clinical reviews
RESISTANCE TRAINING AND MORTALITY RISK: A SYSTEMATIC REVIEW AND META-ANALYSIS
Prathiyankara Shailendra, BMedSci, Katherine L. Baldock, PhD, L.S. Katrina Li, PhD, Jason A. Bennie, PhD, Terry Boyle, PhD
·
Sports Medicine
· 2021
· 9 pages
This study aimed to systematically review and meta-analyze the relationship between resistance training and all-cause, cardiovascular disease, and cancer mortality.
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Guidelines & protocols
FRAMEWORK FOR THE PHARMACOLOGICAL TREATMENT OF OBESITY AND ITS COMPLICATIONS FROM THE EUROPEAN ASSOCIATION FOR THE STUDY OF OBESITY (EASO): 2026 UPDATE
European Association for the Study of Obesity (EASO)
·
Endocrinology
· 2026
· 5 pages
This document provides an updated framework for the pharmacological treatment of obesity and its complications, integrating new trial evidence to refine treatment algorithms for obesity management.
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Clinical reviews
FAST ANTIMICROBIAL SUSCEPTIBILITY TESTING FOR GRAM-NEGATIVE BACTEREMIA
Antibacterial Resistance Leadership Group
·
Infectious Diseases
· 2024
· 12 pages
This document presents the findings of the FAST randomized clinical trial, which evaluates the clinical outcomes of a rapid antimicrobial susceptibility testing method compared to standard testing in patients with bloodstream infections caused by gram-negative bacilli.
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Clinical reviews
MANAGEMENT OF ATHEROSCLEROTIC EXTRACRANIAL CAROTID ARTERY STENOSIS
Leo H Bonati, Olav Jansen, Gert J de Borst, Martin M Brown
·
Neurology
· 2022
· 11 pages
This document discusses the management of atherosclerotic extracranial carotid artery stenosis, focusing on the risks and benefits of various treatment options such as stenting and endarterectomy.
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Clinical reviews
ECHOCARDIOGRAPHY AND PULMONARY EMBOLISM
Loyola University Medical Center, Lewis Katz School of Medicine at Temple University, Thomas Jefferson University Hospital
·
Cardiology
· 21 pages
This document provides a comprehensive overview of the role of echocardiography in the assessment and management of pulmonary embolism (PE), focusing on various echocardiographic parameters and their clinical implications.
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Clinical reviews
INTRAVENOUS IMMUNOGLOBULIN IN IDIOPATHIC INFLAMMATORY MYOPATHIES: A PRACTICAL GUIDE FOR CLINICAL USE
Prateek C. Gandiga, Daniela Ghetie, Elizabeth Anderson, Rohit Aggrawal
·
Rheumatology
· 2023
· 17 pages
This document provides a practical guide for using intravenous immunoglobulin (IVIG) and subcutaneous immunoglobulin (SCIG) in the management of idiopathic inflammatory myopathies (IIM), including various specific conditions and considerations.
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Clinical reviews
GROUP 1 PULMONARY HYPERTENSION WITH ELEVATED PULMONARY ARTERY WEDGE PRESSURE: CHARACTERIZING A COMPLEX PHENOTYPE
Lindsay M. Forbes, MD; William K. Cornwell, MD, MSCS
·
Pulmonology
· 2024
· 4 pages
This editorial discusses the evolving understanding of pulmonary arterial hypertension (PAH) and its phenotypes, particularly focusing on patients with elevated pulmonary artery wedge pressure (PAWP). It highlights the implications of these findings for treatment and diagnosis.
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Clinical reviews
THREE LOW-DOSE ANTIHYPERTENSIVE AGENTS IN A SINGLE PILL AFTER INTRACEREBRAL HEMORRHAGE
The Trident Research Group
·
Neurology
· 2026
· 12 pages
This study investigates whether a single pill combining three low-dose antihypertensive drugs can effectively lower blood pressure and reduce the risk of recurrent stroke in patients with a history of intracerebral hemorrhage.
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Clinical reviews
Asundexian for Secondary Stroke Prevention
The New England Journal of Medicine
·
Neurology
· 2026
· 13 pages
This document discusses the potential of asundexian, a factor XI inhibitor, in conjunction with antiplatelet therapy for the secondary prevention of ischemic stroke in patients with noncardioembolic ischemic stroke or transient ischemic attack.
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Clinical reviews
EARLY-START VS. CONVENTIONAL-START PERITONEAL DIALYSIS IN AKI FROM CARDIORENAL SYNDROME TYPE 1: A RANDOMIZED CONTROLLED TRIAL (STARRT-PD)
Watanyu Parapiboon, Suriyan Yupaniad, Pachara Saengngammongkhol, Piti Niyomsirivanich, Tanin Simtharakaew
·
Nephrology
· 2026
· 9 pages
This study investigates the timing of initiating peritoneal dialysis (PD) in patients with acute kidney injury (AKI) due to cardiorenal syndrome type 1, comparing early-start and conventional-start strategies.
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Clinical reviews
AGING RISES, YET THE DOUBLE BURDEN OF ILLNESS REMAINS
Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA
·
Public Health
· 2026
· 2 pages
This document discusses the epidemiological transition related to aging and the persistent double burden of illness, emphasizing the need for health systems to adapt to the growing prevalence of aging-related diseases.
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Clinical reviews
FLUID RESTRICTION IN PATIENTS WITH HEART FAILURE: A SYSTEMATIC REVIEW
Radboud University Medical Center, Netherlands Heart Institute, Catharina Hospital, Maastricht University Medical Center, Zuyderland Medical Center, Máxima Medical Center
·
Cardiology
· 2025
· 7 pages
This systematic review assesses the efficacy and safety of fluid restriction as a non-pharmacological intervention in the management of heart failure, highlighting recent randomized clinical trial data.
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Clinical reviews
DESIGN PRINCIPLES AND IMPLEMENTATION CONSIDERATIONS FOR ESTABLISHING STROKE UNITS IN LOW-RESOURCE SETTINGS
Lucy Sykes, MBBCh, MA; Dorcas B.C. Gandhi, MPT; Laura Jolliffe, BoCC, PhD; Michele Di Marco, M.Arch, MDMa; Sarah S. Matuja, MD, MMed, MSc; Daniel Youkee, MBBS, MPH, PhD
·
Neurology
· 5 pages
This document outlines key design principles and implementation considerations for establishing stroke units in low-resource settings, emphasizing the importance of multidisciplinary care to improve patient outcomes.
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Clinical reviews
PHARMACOTHERAPY FOR METABOLIC DYSFUNCTION-ASSOCIATED STEATOHEPATITIS: HEART–LIVER CO-MANAGEMENT
Xiao-Dong Zhou, Jeffrey V Lazarus, Chayakrit Krittanawong, Giovanni Targher, Christopher D Byrne, Zobair M Younossi, Frank Tacke, Qin-Fen Chen, Christos S Mantzaros, Herbert Tilg, Wajahat Z Mehal, Laurence S Sperling, Gregory Y H Lip, Norbert Stefan,
·
Gastroenterology
· 17 pages
This review discusses the pharmacological management of metabolic dysfunction-associated steatohepatitis (MASH) and highlights the importance of integrated heart-liver co-management due to shared pathophysiological mechanisms with cardiovascular disease.
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Clinical reviews
VASOPRESSOR WEANING IN SEPTIC SHOCK: THE MISSING PIECE IN THE 2026 GUIDELINES
Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil
·
Critical Care Medicine
· 2026
· 2 pages
This correspondence discusses the gaps in the 2026 Surviving Sepsis Campaign guidelines regarding the de-escalation of vasopressors during septic shock stabilization. It highlights the need for further research on the optimal strategies for vasopressor withdrawal.
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Guidelines & protocols
MANAGEMENT OF ADULT BRONCHIECTASIS: AN AMERICAN COLLEGE OF CHEST PHYSICIANS CLINICAL PRACTICE GUIDELINE
American College of Chest Physicians
·
Pulmonology
· 2026
· 25 pages
This document provides clinical practice guidelines for the management of adult bronchiectasis, focusing on evidence-based recommendations for treatment strategies.
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Guidelines & protocols
CRITERIA FOR THE DIAGNOSIS OF CARDIOGENIC SHOCK—EUROPEAN PERSPECTIVE: A CLINICAL CONSENSUS STATEMENT
Association for Acute CardioVascular Care, Heart Failure Association, European Association of Percutaneous Cardiovascular Interventions
·
Cardiology
· 15 pages
This document presents a clinical consensus statement on the criteria for diagnosing cardiogenic shock from a European perspective, developed by various cardiovascular associations.
6
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Clinical reviews
DIGITAL OUTREACH TO IMPROVE STATIN REFILLS IN PATIENTS WITH LOW STATIN ADHERENCE
Kaiser Permanente Northern California
·
Cardiology
· 2025
· 11 pages
This study investigates the effectiveness of a digital outreach strategy to enhance statin refill rates among patients with low adherence, particularly those with established atherosclerotic cardiovascular disease (ASCVD).
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Clinical reviews
BLEEDING RISK WITH APIXABAN VS. RIVAROXABAN IN ACUTE VENOUS THROMBOEMBOLISM
The New England Journal of Medicine
·
Hematology
· 2026
· 10 pages
This study compares the bleeding risk associated with apixaban and rivaroxaban in patients with acute venous thromboembolism, focusing on clinically relevant bleeding events during a 3-month treatment period.
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Clinical reviews
SPONTANEOUS INTRACEREBRAL HEMORRHAGE: ACUTE TREATMENT AND PROGNOSIS
Guy Rordorf, MD, Colin T McDonald, MD
·
Neurology
· 2026
· 53 pages
This document reviews the acute treatment and prognosis of spontaneous intracerebral hemorrhage (ICH), focusing on preventing hemorrhage expansion and managing complications.
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Clinical reviews
FINERENONE IN TYPE 1 DIABETES AND CHRONIC KIDNEY DISEASE
null
·
Nephrology
· 2026
· 11 pages
This study investigates the efficacy and safety of finerenone, a nonsteroidal mineralocorticoid receptor antagonist, in adults with type 1 diabetes and chronic kidney disease (CKD).
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Clinical reviews
GENITOURINARY TRACT INFECTIONS AND SGLT2 INHIBITORS IN HEART FAILURE: AN EMPEROR-POOLED ANALYSIS
University of Porto, Centre d'Investigations Cliniques, Baylor Scott and White Research Institute, National and Kapodistrian University of Athens, German Heart Center Charité, Baylor University Medical Center, Imperial College
·
Cardiology
· 2026
· 10 pages
This document analyzes the relationship between sodium glucose co-transporter-2 inhibitors (SGLT2i) and the occurrence of genitourinary tract infections (UTIs) in patients with heart failure. It highlights the implications of UTIs on mortality risk and hospitalization.
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