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Clinical reviews
EFFECTS OF BLOOD PRESSURE AND TRANEXAMIC ACID IN SPONTANEOUS INTRACEREBRAL HAEMORRHAGE: A SECONDARY ANALYSIS OF A LARGE RANDOMISED CONTROLLED TRIAL
Jason Philip Appleton, Zhe Kang Law, Lisa Jane Woodhouse, Rustam Al-Shahi Salman, Maia Beridze, Hanne Christensen, Robert A Dineen, Juan José Egea Guerrero, Timothy J England, Michal Karlinski, Kailash Krishnan, Ann Charlotte Laska, Philippe Lyrer,
·
Neurology
· 2023
· 10 pages
This study investigates the interaction between baseline systolic blood pressure and the effect of tranexamic acid on functional outcomes in patients with spontaneous intracerebral hemorrhage.
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Clinical reviews
PULMONARY HYPERTENSION ASSOCIATED WITH LEFT HEART DISEASE
Clinic III for Internal Medicine (Dept. of Cardiology, Pulmonology, and Intensive Care Medicine), Cologne Cardiovascular Research Center (CCRC), Heart Center at the University Hospital Cologne, Center for Molecular Medicine Cologne (CMMC), Faculty of
·
Cardiology
· 2023
· 8 pages
This document reviews the complexities of pulmonary hypertension (PH) in patients with left heart disease (LHD), focusing on updated hemodynamic definitions and management strategies.
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Clinical reviews
TREATMENT OF GESTATIONAL DIABETES MELLITUS DIAGNOSED EARLY IN PREGNANCY
D. Simmons, J. Immanuel, W.M. Hague, H. Teede, C.J. Nolan, M.J. Peek, J.R. Flack, M. McLean, V. Wong, E. Hibbert, A. Kautzky-Willer, J. Harreiter, H. Backman, E. Gianatti, A. Sweeting, V. Mohan, J. Enticott, N.W. Cheung
·
Obstetrics and Gynecology
· 2023
· 13 pages
This original article investigates whether early treatment of gestational diabetes mellitus (GDM) diagnosed before 20 weeks of gestation can improve maternal and infant health outcomes.
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Clinical reviews
DEXAMETHASONE VERSUS SURGERY FOR CHRONIC SUBDURAL HEMATOMA
Amphia Hospital, Leiden University Medical Center, Haaglanden Medical Center, Erasmus Medical Center, University of Groningen, Isala, Medisch Spectrum Twente, University of Twente
·
Neurosurgery
· 2023
· 11 pages
This article compares the efficacy of dexamethasone treatment versus surgical intervention for patients with chronic subdural hematoma.
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Clinical reviews
EFFECTIVENESS OF SPIRONOLACTONE FOR WOMEN WITH ACNE VULGARIS
BMJ
·
Dermatology
· 2023
· 10 pages
This document assesses the effectiveness of oral spironolactone for treating acne vulgaris in adult women through a pragmatic, multicentre, phase 3, double-blind, randomized controlled trial.
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Clinical reviews
Neonatal Seizures
Montefiore Medical Center, Albert Einstein College of Medicine
·
Pediatrics
· 2023
· 9 pages
Neonatal seizures are defined as seizures occurring within 4 weeks after birth in full-term infants or within 44 weeks of postmenstrual age in preterm infants. The article discusses their incidence, classification, and common causes such as metabolic disturbances, infections, and cerebral lesions.
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Clinical reviews
THE UTILITY OF INVASIVE HEMODYNAMICS IN THE MANAGEMENT OF CARDIOGENIC SHOCK
Western University, London Health Sciences Centre, London, Ontario, Canada
·
Cardiology
· 2023
· 3 pages
This article discusses the role of pulmonary artery catheters (PACs) in the management of cardiogenic shock, highlighting their potential benefits and the variability of their use in Canada.
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Clinical reviews
CENTRAL VENOUS PRESSURE (CVP)
Olfa Hamzaoui and Jean-Louis Teboul
·
Critical Care
· 2022
· 3 pages
This article discusses the significance of central venous pressure (CVP) in assessing hemodynamic status and guiding fluid therapy in critically ill patients. It emphasizes the importance of accurate measurement techniques and the implications of CVP on organ perfusion.
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Clinical reviews
Early versus Later Anticoagulation for Stroke with Atrial Fibrillation
U. Fischer, M. Koga, D. Strbian, M. Branca, S. Abend, S. Trelle, M. Paciaroni, G. Thomalla, P. Michel, K. Nedeltchev, L.H. Bonati, G. Ntaios, T. Gattringer, E.-C. Sandset, P. Kelly, R. Lemmens, P.N. Sylaja, D. Aguiar de Sousa, N.M. Bornstein, Z.
·
Neurology
· 11 pages
This article investigates the effect of early versus later initiation of direct oral anticoagulants (DOACs) in patients with atrial fibrillation who have experienced an acute ischemic stroke. The study performed an investigator-initiated, open-label trial across 103 sites in 15 countries.
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Clinical reviews
SARCOPENIA AND CARDIOVASCULAR DISEASES
Inova Heart and Vascular Institute; Johns Hopkins University School of Medicine; Cleveland Clinic; University of Arizona; University of Connecticut; Weill Cornell Medicine; University of Washington; University of Texas; University of Pittsburgh; Kaiser
·
Cardiology
· 20 pages
This document discusses the relationship between sarcopenia, characterized by the loss of muscle strength and mass, and cardiovascular diseases, highlighting the increased risks associated with these conditions, particularly in older adults.
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Clinical reviews
COMPARATIVE EFFECTIVENESS OF ASPIRIN DOSING IN CARDIOVASCULAR DISEASE
The New England Journal of Medicine
·
Cardiology
· 2021
· 10 pages
This study investigates the appropriate dose of aspirin to lower the risk of death, myocardial infarction, and stroke while minimizing major bleeding in patients with established atherosclerotic cardiovascular disease.
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Clinical reviews
EFFICACY AND SAFETY OF SULBACTAM–DURLobactam VERSUS COLISTIN FOR THE TREATMENT OF PATIENTS WITH SERIOUS INFECTIONS CAUSED BY ACINETOBACTER BAUMANNII–CALCOACETICUS COMPLEX: A MULTICENTRE, RANDOMISED, ACTIVE-CONTROLLED, PHASE 3, NON-INFERIORITY CLINICAL
Keith S Kaye, Andrew F Shorr, Richard G Wunderink, Bin Du, Gabrielle E Poirier, Khurram Rana, Alita Miller, Drew Lewis, John O'Donnell, Lan Chen, Harald Reinhart, Subasree Srinivasan, Robin Isaacs, David Altarac
·
Infectious Disease
· 13 pages
This document presents the findings of a phase 3 clinical trial comparing the efficacy and safety of sulbactam–durlobactam versus colistin for treating serious infections caused by carbapenem-resistant Acinetobacter baumannii–calcoaceticus complex.
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Clinical reviews
THE 2023 DUKE - ISCVID CRITERIA FOR INFECTIVE ENDOCARDITIS: UPDATING THE MODIFIED DUKE CRITERIA
Duke University Medical Center; Duke Clinical Research Institute
·
Infectious Disease
· 2023
· 22 pages
This article discusses the updated criteria for diagnosing infective endocarditis, focusing on the modifications to the Duke criteria. It provides insights into the new major and minor criteria based on recent evidence.
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Clinical reviews
DRUG THERAPY FOR TREATING POST-DURAL PUNCTURE HEADACHE (REVIEW)
Cochrane Database of Systematic Reviews
·
Anesthesiology
· 2015
· 44 pages
This Cochrane Review evaluates the effectiveness of various drug therapies for treating post-dural puncture headache.
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Clinical reviews
MANAGEMENT OF THYROID NODULES
Erik K Alexander, Gerard M Doherty, Justine A Barletta
·
Endocrinology
· 2022
· 9 pages
This document discusses the rise in detection of thyroid nodules and the evolving management strategies that emphasize individualized care and conservative approaches.
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Clinical reviews
NEW INSIGHTS INTO THE FLUID MANAGEMENT IN PATIENTS WITH SEPTIC SHOCK
Fourth Department of Internal Medicine, School of Medicine, Attikon University Hospital, National and Kapodistrian University of Athens; Second Department of Pediatrics, Aghia Sophia Children’s Hospital; First Department of Pediatric Surgery, Aghia
·
Critical Care Medicine
· 23 pages
This review discusses the current understanding and recommendations for fluid management in patients experiencing septic shock, emphasizing the importance of early fluid resuscitation.
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Clinical reviews
OBESITY AND CHRONIC KIDNEY DISEASE: A CURRENT REVIEW
Faculty of Biology, Medicine and Health, University of Manchester; Department of Renal Medicine, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust; Department of Diabetes, Endocrinology and Obesity Medicine, Salford Royal Hospital
·
Nephrology
· 2023
· 14 pages
This review explores the significant challenges posed by obesity to healthcare, particularly its relationship with chronic kidney disease (CKD). It presents findings from a literature search on the interplay between obesity and CKD, highlighting direct and indirect associations.
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Clinical reviews
ANTIPLATELET AGENTS IN ACUTE ST ELEVATION MYOCARDIAL INFARCTION
Oregon Health and Science University, Portland, Ore.
·
Cardiology
· 2022
· 12 pages
This article reviews the mechanisms, pharmacokinetics, and key clinical trials related to platelet inhibitors used in the management of ST elevation myocardial infarction (STEMI). It highlights the role of platelet aggregation in acute coronary syndrome and discusses current recommendations from the American College of Cardiology/American Heart Association.
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Clinical reviews
EVALUATING ANTIMICROBIAL DURATION FOR GRAM-NEGATIVE BACTEREMIA IN PATIENTS WITH NEUTROPENIA DUE TO HEMATOLOGIC MALIGNANCY OR HEMATOPOIETIC STEM CELL TRANSPLANTATION
Mayo Clinic, Rochester, Minnesota, USA
·
Infectious Diseases
· 2023
· 9 pages
This study investigates the outcomes of varying durations of antimicrobial therapy for Gram-negative bloodstream infections in neutropenic patients, focusing on short, intermediate, and prolonged treatment courses.
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Clinical reviews
SARCOPENIA AND CARDIOVASCULAR DISEASES
Inova Heart and Vascular Institute; Johns Hopkins University School of Medicine; Cleveland Clinic; University of Arizona; University of Connecticut; Weill Cornell Medicine; University of Washington; University of Texas; University of Pittsburgh;
·
Cardiology
· 20 pages
This document discusses the relationship between sarcopenia, characterized by loss of muscle strength and mass, and various cardiovascular diseases. It highlights the implications of sarcopenia on patient outcomes, particularly in older adults.
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Clinical reviews
THE CLINICAL UTILITY OF KINETIC GLOMERULAR FILTRATION RATE
Royal Infirmary of Edinburgh, Queen Margaret Hospital
·
Nephrology
· 2016
· 7 pages
This article assesses the clinical utility of kinetic glomerular filtration rate (kGFR) as a predictive tool for adverse renal outcomes in acutely unwell patients with rapidly changing renal function.
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Clinical reviews
MECHANICAL VENTILATION IN ACUTE BRAIN INJURY PATIENTS WITH ACUTE RESPIRATORY DISTRESS SYNDROME
Johns Hopkins University School of Medicine, The Prince Charles Hospital, Griffith University
·
Critical Care Medicine
· 2022
· 7 pages
This mini review discusses the complexities of mechanical ventilation in patients with acute brain injury who also suffer from acute respiratory distress syndrome (ARDS). It highlights the prevalence of ARDS in this population and the specific ventilation strategies that may be beneficial or detrimental.
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Clinical reviews
TRANEXAMIC ACID TO PREVENT OBSTETRICAL HEMORRHAGE AFTER CESAREAN DELIVERY
Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network
·
Obstetrics and Gynecology
· 2023
· 11 pages
This original article investigates the prophylactic use of tranexamic acid during cesarean deliveries to assess its impact on blood loss and the need for blood transfusions.
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Clinical reviews
INTRAVENOUS IRON VS. ORAL IRON IN IRON DEFICIENCY ANEMIA
University of North Carolina, Atrium Health–Cabarrus Family Medicine Residency Program, Prevea Health Eau Claire Family Medicine Residency Program
·
Family Medicine
· 2022
· 2 pages
This document evaluates the effectiveness of intravenous iron compared to oral iron in preventing blood transfusions in adults with iron deficiency anemia.
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