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Clinical reviews
COMBINING GLUCAGON - LIKE PEPTIDE - 1 RECEPTOR AGONISTS (GLP - 1RAS) AND SODIUM - GLUCOSE COTRANSPORTER - 2 INHIBITORS (SGLT2IS) IN PATIENTS WITH TYPE 2 DIABETES MELLITUS (T2DM)
Pierre Gourdy, Patrice Darmon, François Dievart, Jean‑Michel Halimi, Bruno Guerci
·
Endocrinology
· 2023
· 14 pages
This review discusses the mechanistic and clinical synergies of combining glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) for treating type 2 diabetes mellitus (T2DM). It highlights the benefits of this combination therapy on metabolic, cardiovascular, and renal outcomes.
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Clinical reviews
ANTITHROMBOTIC THERAPY IN PATIENTS WITH ATRIAL FIBRILLATION TREATED WITH ORAL ANTICOAGULATION UNDERGOING PERCUTANEOUS CORONARY INTERVENTION
Dominick J. Angiolillo, Deepak L. Bhatt, Christopher P. Cannon, John W. Eikelboom, C. Michael Gibson, Shaun G. Goodman, Christopher B. Granger, David R. Holmes, Renato D. Lopes, Roxana Mehran, David J. Moliterno
·
Cardiology
· 2021
· 14 pages
This document provides an updated perspective on the management of antithrombotic therapy in patients with atrial fibrillation undergoing percutaneous coronary intervention (PCI). It highlights the challenges and recommendations for optimal antithrombotic management in this patient population.
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Clinical reviews
LOW BACK PAIN
Aidan G. Cashin, PhD; Roger Chou, MD; Melissa B. Weimer, DO, MCR; James H. McAuley, PhD
·
Pain Medicine
· 15 pages
This document provides a comprehensive review of low back pain, including its definition, prevalence, and treatment options. It emphasizes the significance of nonspecific low back pain and its impact on global health.
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Clinical reviews
TUBERCULOSIS
University College London, Imperial College London
·
Infectious Disease
· 2026
· 16 pages
This article provides a comprehensive overview of tuberculosis (TB), including its prevention, screening, diagnosis, and treatment strategies.
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Clinical reviews
CLINICAL IMPACT OF ADJUSTED VALPROIC ACID LEVEL IN PATIENTS WITH HYPOALBUMINEMIA
American College of Clinical Pharmacology
·
Clinical Pharmacology
· 2026
· 11 pages
This study evaluates the impact of adjusted valproic acid concentration in predicting effectiveness and adverse effects in patients with hypoalbuminemia compared to total valproic acid levels.
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Clinical reviews
ARTERIOVENOUS MALFORMATIONS OF THE BRAIN
New York Presbyterian Hospital, Columbia University
·
Neurosurgery
· 2017
· 8 pages
This review addresses arteriovenous malformations involving the brain parenchyma, characterized by a nidus of abnormal vessels that form a direct transition between arteries and veins without intervening capillaries.
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Clinical reviews
ASTHMA
Department of Respiratory and Infectious Diseases, Bispebjerg Hospital, Copenhagen, Denmark; Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet
·
Pulmonology
· 2023
· 16 pages
Asthma is one of the most common chronic non-communicable diseases worldwide, characterized by variable airflow obstruction, causing dyspnoea and wheezing. This document provides a clinically focused overview of asthma, including its epidemiology, pathophysiology, diagnosis, and management in both children and adults.
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Clinical reviews
CLINDAMYCIN PLUS VANCOMYCIN VERSUS LINEZOLID FOR TREATMENT OF NECROTIZING SOFT TISSUE INFECTION
Presbyterian Hospital Department of Pharmacy, UPMC; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine; Department of Surgery, University of Rochester Medical Center; Department of Surgery and Critical
·
Infectious Diseases
· 14 pages
This study evaluates the safety and efficacy of clindamycin plus vancomycin compared to linezolid as empiric treatment for necrotizing soft tissue infections (NSTIs).
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Clinical reviews
WHAT'S NEW IN INTENSIVE CARE
Département Médico-Universitaire DREAM, Sorbonne University of Paris, Paris, France
·
Intensive Care
· 2023
· 5 pages
This document discusses the use of aerosolized antibiotics in critically ill patients, particularly those on mechanical ventilation, highlighting the importance of delivery techniques and the pharmacological effects of various inhaled medications.
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Clinical reviews
MULTIPLE MYELOMA: 2026 UPDATE ON DIAGNOSIS, RISK-STRATIFICATION AND MANAGEMENT
Mayo Clinic
·
Hematology
· 2026
· 24 pages
This document provides an updated overview of the diagnosis, risk stratification, and management strategies for multiple myeloma as of 2026.
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Clinical reviews
HEART FAILURE WITH MILDLY REDUCED EJECTION FRACTION: A CALL FOR A PRECISION MEDICINE APPROACH
American College of Cardiology
·
Cardiology
· 2026
· 17 pages
This document discusses heart failure with mildly reduced ejection fraction (HFmrEF) as a distinct phenotype within the heart failure spectrum, emphasizing the need for precision medicine in its management.
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Clinical reviews
AMYOTROPHIC LATERAL SCLEROSIS: A REVIEW
John Ravits, MD; Dominic Ferrey, MD; Betul Gundogdu, MD; Wali Qayoumi, MD; Chelsea Zale, DO
·
Neurology
· 2026
· 13 pages
This document provides a comprehensive review of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by progressive weakness due to degeneration of upper and lower motor neurons.
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Clinical reviews
SYSTEMIC LUPUS ERYTHEMATOSUS: DIAGNOSIS AND TREATMENT
St. Luke's Bethlehem Family Medicine Residency, St. Luke's University Hospital
·
Rheumatology
· 2023
· 13 pages
This document provides a comprehensive overview of systemic lupus erythematosus (SLE), an autoimmune disease affecting multiple organ systems, detailing its diagnosis and management strategies.
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Clinical reviews
EFFICACY AND SAFETY OF CIPROFOL SEDATION IN ICU PATIENTS UNDERGOING MECHANICAL VENTILATION: A MULTICENTER, SINGLE-BLIND, RANDOMIZED, NONINFERIORITY TRIAL
Intensive Care Medicine
· 2023
· 10 pages
This study evaluates the effectiveness and safety of ciprofol for sedation in ICU patients requiring mechanical ventilation. It compares ciprofol with propofol in a multicenter, randomized trial.
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Clinical reviews
ALBUMIN REPLACEMENT THERAPY IN SEPTIC SHOCK
SepNet Critical Care Trials Group
·
Critical Care Medicine
· 2023
· 12 pages
This document presents a randomized clinical trial assessing the impact of albumin administration on outcomes in patients with septic shock.
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Clinical reviews
VASOPRESSIN IN CARDIOGENIC SHOCK: PATHOPHYSIOLOGY, CLINICAL EVIDENCE, AND THERAPEUTIC PERSPECTIVES
Department of Cardiovascular Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS; Berne Cardiovascular Research Center, University of Virginia; Department of Cardiovascular and Respiratory Sciences, Catholic University of the Sacred Heart
·
Cardiology
· 2026
· 9 pages
This review presents a comprehensive synthesis of the pharmacologic mechanisms, haemodynamic effects, and clinical applications of vasopressin in cardiogenic shock. It highlights patient profiles that may benefit from vasopressin and outlines scenarios where its use may be detrimental.
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Clinical reviews
HEMODIALYSIS EMERGENCIES: CORE CURRICULUM 2021
MedStar Georgetown University Hospital
·
Nephrology
· 2021
· 14 pages
This document reviews the pathogenesis, management, and prevention of nine hemodialysis emergencies, including serious complications that can occur during the procedure.
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Clinical reviews
ERROR TRAPS IN PEDIATRIC ADENOTONSILLECTOMY: CLINICAL PATTERNS, COGNITIVE PITFALLS, AND EVIDENCE-MITIGATION STRATEGIES
Children's Hospital Colorado, University of Colorado Anschutz; Seattle Children's Hospital, University of Washington; Children's Hospital of Eastern Ontario Research Institute, University of Ottawa
·
Pediatric Anesthesia
· 2026
· 15 pages
This educational review discusses common error traps in pediatric adenotonsillectomy, highlighting clinical patterns and cognitive pitfalls that can lead to perioperative adverse events. It emphasizes the importance of evidence-based strategies to mitigate these risks.
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Clinical reviews
VASOPRESSOR CHOICE AND TIMING IN VASODILATORY SHOCK
Patrick M. Wieruszewski, Ashish K. Khanna
·
Intensive Care Medicine
· 2022
· 8 pages
This article reviews the selection and timing of vasopressors in the management of vasodilatory shock, particularly in the context of intensive care settings.
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Clinical reviews
TO WEAN OR NOT TO WEAN: A PRACTICAL PATIENT FOCUSED GUIDE TO VENTILATOR WEANING
Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center
·
Critical Care Medicine
· 2022
· 9 pages
This document provides a comprehensive overview of ventilator weaning, discussing the evolution of practices and the challenges faced in intensive care units. It highlights various techniques and predictors associated with successful weaning from mechanical ventilation.
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Clinical reviews
ANTIDOTES FOR ANTICOAGULATION REVERSAL
Bianca Rocca, M.D., Ph.D., Hugo ten Cate, M.D., Ph.D.
·
Hematology
· 20 pages
This review article discusses the increasing use of anticoagulants and the corresponding need for effective reversal strategies in cases of major bleeding. It highlights various antidotes and their mechanisms, as well as challenges in dosing and monitoring.
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Clinical reviews
BLEEDING AND THROMBOTIC COMPLICATIONS IN PATIENTS WITH CIRRHOSIS: A STATE-OF-THE-ART APPRAISAL
Université Paris-Cité, University of Virginia, University of Modena and Reggio Emilia
·
Gastroenterology
· 14 pages
This document provides a comprehensive review of the coagulopathy associated with liver disease, highlighting the paradox of hypercoagulability in patients with cirrhosis despite a tendency for bleeding.
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Clinical reviews
A PRACTICAL APPROACH TO IN-HOSPITAL MANAGEMENT OF NEW-ONSET REFRACTORY STATUS EPILEPTICUS/FEBRILE INFECTION RELATED EPILEPSY SYNDROME
Zubeda Sheikh, Lawrence J. Hirsch
·
Neurology
· 11 pages
This document provides a comprehensive approach to managing new-onset refractory status epilepticus (NORSE) and febrile infection related epilepsy syndrome (FIRES) in a hospital setting. It discusses diagnostic criteria, treatment protocols, and the importance of timely immunotherapy.
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Clinical reviews
POST-TRANSPLANTATION CYCLOPHOSPHAMIDE AND ANTHYMOCTE GLOBULIN IN 8/10 HLA-MISMATCHED UNRELATED DONOR TRANSPLANTATION
null
·
Hematology
· 2025
· 10 pages
This article analyzes the outcomes of allogeneic hematopoietic cell transplantation (alloHCT) from 8/10 HLA-matched unrelated donors, focusing on the use of post-transplantation cyclophosphamide and antithymocyte globulin.
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