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Clinical reviews
LINERIXIBAT IN PATIENTS WITH PRIMARY BILIARY CHOLANGITIS AND CHOLESTATIC PRURITUS (GLISTEN): A RANDOMISED, MULTICENTRE, DOUBLE-BLIND, PLACEBO-CONTROLLED, PHASE 3 TRIAL
GLISTEN Study Group
·
Gastroenterology
· 2025
· 12 pages
This document presents the findings of a phase 3 trial evaluating the safety and efficacy of linerixibat, an ileal bile acid transporter inhibitor, as a specific antipruritic therapy for patients with primary biliary cholangitis (PBC) and cholestatic pruritus.
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Clinical reviews
Management of Cardiogenic Shock in Patients with Acute Myocardial Infarction
Katherine J. Kunkel, MD, MSEd, Brittany Fuller, MD, Mir B. Basir, DO
·
Cardiology
· 13 pages
This document discusses the management strategies for cardiogenic shock in patients experiencing acute myocardial infarction, emphasizing the importance of early identification and mechanical support.
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Clinical reviews
SYSTEMATIC REVIEW AND META-ANALYSIS OF DIAGNOSTIC TEST ACCURACY OF ST-SEGMENT ELEVATION FOR ACUTE CORONARY OCCLUSION
Instituto Dante Pazzanese de Cardiologia, São Paulo, Brazil
·
Cardiology
· 2021
· 7 pages
This systematic review evaluates the diagnostic sensitivity and specificity of ST-segment elevation on a 12-lead ECG in detecting acute coronary occlusion (ACO). It challenges the current STEMI-NSTEMI paradigm by analyzing data from multiple studies.
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Clinical reviews
SYSTEMIC LUPUS ERYTHEMATOSUS IN CRITICAL CARE: A SYSTEMATIC REVIEW OF ICU OUTCOMES AND MANAGEMENT
Edith Ramírez-Lara, Claudia Mendoza-Pinto, Pamela Munguía-Realpozo, Miguel Ángel Saavedra-Salinas, Ivet Etchegaray-Morales, Jorge Ayón-Aguilar, Álvaro José Montiel-Jarquín, Socorro Martínez-Méndez
·
Rheumatology
· 10 pages
This document provides a systematic review of the outcomes and management strategies for patients with systemic lupus erythematosus (SLE) admitted to intensive care units (ICUs). It synthesizes recent evidence on causes of ICU admission, mortality predictors, and therapeutic approaches.
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Clinical reviews
BEYOND THE 4 PILLARS
Città della Salute e della Scienza Hospital, Turin, Italy
·
Cardiology
· 4 pages
This editorial comment discusses the role of vericiguat in the management of heart failure with reduced ejection fraction (HFrEF), emphasizing its potential benefits and the challenges in treatment outcomes.
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Clinical reviews
ALDOSTERONE SYNTHASE INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASE
Gian Paolo Rossi, Federico Bernardo Rossi, Andrea Cignarella, Teresa Maria Seccia
·
Cardiology
· 2026
· 11 pages
This review discusses the role of aldosterone synthase inhibitors (ASIs) in managing cardiovascular diseases, particularly focusing on their efficacy in lowering aldosterone levels and blood pressure in patients with resistant hypertension.
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Clinical reviews
TIME TO MOVE BEYOND THE STATIN NOCEBO EFFECT
Yale School of Medicine
·
Cardiology
· 3 pages
This editorial discusses the challenges associated with statin therapy, particularly the nocebo effect that leads many patients to discontinue their medication despite its proven benefits in cardiovascular prevention.
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Clinical reviews
MAP EGDT DO2 ED SSC VO2 CRT POCUS CCE FR CRT-PHR ICU CVP SOFA
Dr. Luis Tisn
·
Critical Care Medicine
· 2026
· 13 pages
This document discusses the evolution of septic shock management, emphasizing the transition from fixed protocols to personalized, physiology-driven resuscitation strategies.
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Clinical reviews
SGLT2 INHIBITORS AND RISK OF DISTANT METASTASIS IN PATIENTS WITH BREAST CANCER AND TYPE 2 DIABETES: A TARGET TRIAL EMULATION WITH BIOLOGICAL PLAUSIBILITY ANALYSIS
Tri-Service General Hospital, College of Medicine, National Defense Medical University, Taipei, Taiwan
·
Oncology
· 15 pages
This study investigates the association between SGLT2 inhibitor use and the risk of distant metastasis in patients with breast cancer and type 2 diabetes. It employs a target trial emulation methodology to analyze data from a large patient population.
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Clinical reviews
FEMORAL VEIN PULSATILITY: A SIMPLE TOOL FOR VENOUS CONGESTION ASSESSMENT
V. Bhardwaj, P. Rola, A. Denault, G. Vikneswaran, R. Spiegel
·
Cardiology
· 10 pages
This article discusses the use of femoral vein Doppler (FVD) as a simpler alternative to the VExUS score for assessing venous congestion in adult post-cardiac surgery patients.
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Clinical reviews
SAFETY, TOLERABILITY, AND EFFICACY OF UP-TITRATION OF GUIDELINE-DIRECTED MEDICAL THERAPIES FOR ACUTE HEART FAILURE (STRONG-HF): A MULTINATIONAL, OPEN-LABEL, RANDOMISED, TRIAL
Université Paris Cité, INSERM UMR-S 942 (MASCOT), Paris, France
·
Cardiology
· 2022
· 15 pages
This document presents the findings of a multinational trial assessing the safety, tolerability, and efficacy of up-titration of guideline-directed medical therapies in patients with acute heart failure.
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Clinical reviews
CURRENT CONCEPTS IN CORONARY ARTERY REVASCULARISATION
Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA; Department of Cardiovascular, Policlinico Universitario Gemelli IRCCS, Rome, Italy; Osaka Hospital, Osaka, Japan
·
Cardiology
· 2023
· 18 pages
This document discusses the methods of coronary artery revascularisation, including surgical and percutaneous approaches, highlighting their respective risks and benefits. It emphasizes the importance of medical therapy in conjunction with revascularisation.
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Clinical reviews
THE ROLE OF β-BLOCKERS IN THE EVOLVING TREATMENT LANDSCAPE OF RESISTANT HYPERTENSION
Stefano Masi, Atul Pathak, Rosa Maria Bruno, Sofie Brouwers, Krzysztof Narkiewicz, Stefano Taddei, Konstantinos Tsioufis, Reinhold Kreutz
·
Cardiology
· 2026
· 21 pages
This narrative review summarizes mechanistic insights and evidence from clinical trials and real-world studies regarding the management of resistant hypertension (RHTN), focusing on the role of β-blockers.
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Clinical reviews
ANTISEIZURE MEDICATION DOSING AND MONITORING IN THE INTENSIVE CARE UNIT: A PRACTICAL NARRATIVE REVIEW
Andrew J. Webb, Brooke Barlow, Stephanie L. Seto, Carolina B. Maciel, Joanna Brennan, Aaron M. Cook
·
Critical Care Medicine
· 2026
· 16 pages
This narrative review discusses the pharmacokinetics, dosing considerations, and therapeutic drug monitoring of antiseizure medications (ASMs) in the intensive care unit (ICU). It highlights the differences in ASM management due to organ dysfunction and the severity of illness.
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Clinical reviews
MONITORING RESPIRATORY MUSCLES EFFORT DURING MECHANICAL VENTILATION
Julien P. van Oosten, Evangelia Akoumianaki, Annemijn H. Jonkman
·
Pulmonology
· 9 pages
This review summarizes basic physiological concepts of breathing effort and outlines various methods for monitoring the effort of inspiratory and expiratory muscles during mechanical ventilation.
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Clinical reviews
NECROTISING SOFT-TISSUE INFECTIONS
Service de Dermatologie
·
Infectious Disease
· 2022
· 14 pages
This review focuses on the management of necrotising soft-tissue infections, emphasizing the importance of prompt recognition and surgical intervention to improve patient outcomes.
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Clinical reviews
Intravenous albumin after outpatient paracentesis reduces the risk of AKI hospitalization: A national cohort study
Department of Medicine, Corporal Michael J. Crescenz VA Medical Center; Department of Medicine, University of Pennsylvania Perelman School of Medicine
·
Hepatology
· 2026
· 12 pages
This study evaluates the association between intravenous albumin administration after outpatient paracentesis and the risk of acute kidney injury (AKI) hospitalization in patients with cirrhosis.
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Clinical reviews
ANTAGONIZING THE LEPTIN RECEPTOR IN OBESITY
Clifford J. Rosen, M.D.
·
Pediatrics
· 2023
· 3 pages
This document discusses the challenges of childhood obesity, particularly focusing on the role of leptin and its receptor in obesity treatment. It highlights recent findings regarding genetic variants in the leptin gene that affect treatment efficacy.
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Clinical reviews
LIVER TRANSPLANTATION FOR PATIENTS WITH SEVERE ACUTE ON CHRONIC LIVER FAILURE: IT IS TIME TO CHANGE PARADIGMS
Thierry Artzner, Javier Fernandez, Rajiv Jalan
·
Hepatology
· 3 pages
This document discusses the critical outcomes and management strategies for patients with severe acute on chronic liver failure (ACLF) and the role of liver transplantation in improving survival rates.
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Clinical reviews
CARDIORENAL SYNDROME AND DIABETES: AN EVIL PAIRING
Hospital Universitario Vall d'Hebron, Barcelona, Spain
·
Cardiology
· 2023
· 12 pages
This document discusses the interplay between cardiorenal syndrome and diabetes, highlighting the implications for patient management and treatment strategies.
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Clinical reviews
MANAGEMENT OF TRADITIONAL RISK FACTORS FOR THE DEVELOPMENT AND PROGRESSION OF CHRONIC KIDNEY DISEASE
Harold Simmons Center for Chronic Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California Irvine; Tibor Rubin Veterans Affairs Medical Center
·
Nephrology
· 2023
· 46 pages
This review discusses major risk factors for incident chronic kidney disease (CKD) and CKD progression, categorized across various domains including cardiovascular, endocrine, lifestyle, and genetic/environmental factors.
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Clinical reviews
ULTRASONOGRAPHIC ASSESSMENT OF DIAPHRAGMATIC FUNCTION AND ITS CLINICAL APPLICATION IN THE MANAGEMENT OF PATIENTS WITH ACUTE RESPIRATORY FAILURE
Division of Respiratory Diseases, Ospedale Luigi Sacco, Polo Universitario, ASST Fatebenefratelli-Sacco; Department of Biomedical and Clinical Sciences (DIBIC), Università degli Studi di Milano
·
Pulmonology
· 13 pages
This document reviews the use of ultrasonography to assess diaphragmatic function, particularly in patients experiencing acute respiratory failure. It highlights the clinical implications of diaphragm dysfunction and the utility of ultrasound as a noninvasive diagnostic tool.
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Clinical reviews
THE MEDICAL TREATMENT OF CARDIOGENIC SHOCK
Service de Médecine Intensive et Réanimation Brabois, CHRU Nancy, INSERM U1116, Université de Lorraine
·
Cardiology
· 10 pages
This review discusses the presentation and management of cardiogenic shock (CS), a leading cause of mortality worldwide, and explores recent advancements in its treatment.
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Clinical reviews
ACUTE KIDNEY INJURY IN PATIENTS WITH CIRRHOSIS
Keck School of Medicine, University of Southern California; Yale University School of Medicine
·
Nephrology
· 2023
· 13 pages
This review article discusses the prevalence and management of acute kidney injury (AKI) in patients with cirrhosis, highlighting its significant morbidity and mortality rates.
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