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Clinical reviews
PHARMACOTHERAPY OF HEART FAILURE A.D. 2023
Medical University of Lodz, Collegium Medicum Jan Kochanowski University, Maria Skłodowska-Curie Medical Academy, Medical University of Warsaw, Świętokrzyskie Cardiology Center
·
Cardiology
· 2023
· 20 pages
This document provides expert opinions on the pharmacotherapy of heart failure, focusing on recent advancements and recommendations in treatment strategies.
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Clinical reviews
INDIVIDUALISED ANTIMICROBIAL DOSE OPTIMISATION: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMISED CONTROLLED TRIALS
Maria Sanz Codina, Haktan Övul Bozkir, Anselm Jorda, Markus Zeitlinger
·
Infectious Diseases
· 2023
· 36 pages
This document presents a systematic review and meta-analysis focused on the optimization of individualized antimicrobial dosing based on randomized controlled trials.
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Clinical reviews
GLP1 and GIP Receptor Agonists: Effects on the Gastrointestinal Tract and Management Strategies for Primary Care Physicians
Mayo Clinic
·
Internal Medicine
· 2025
· 9 pages
This concise review discusses the effects of GLP1 and GIP receptor agonists on the gastrointestinal tract and outlines management strategies for primary care physicians. It covers common gastrointestinal adverse events and their management, as well as the impact of these medications on endoscopic procedures.
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Clinical reviews
ASPIRIN WITH OR WITHOUT STATIN IN INDIVIDUALS WITHOUT ATHEROSCLEROTIC CARDIOVASCULAR DISEASE ACROSS RISK CATEGORIES
American College of Cardiology Foundation
·
Cardiology
· 2023
· 12 pages
This study examines the effects of aspirin in adults without atherosclerotic cardiovascular disease, stratified by statin use across different ASCVD risks.
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Clinical reviews
EASY-WPW: a novel ECG-algorithm for easy and reliable localization of manifest accessory pathways in children and adults
Herz- und Diabeteszentrum NRW, Ruhr-Universität Bochum, Georgstr. 11, 32545 Bad Oeynhausen, Germany
·
Cardiology
· 2022
· 10 pages
This clinical research paper introduces the EASY-WPW algorithm, a new electrocardiogram (ECG) based method designed for the accurate and straightforward localization of accessory pathways in both pediatric and adult patients. The study evaluates its performance against existing algorithms.
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Clinical reviews
MULTIFACTORIAL PATHOGENESIS OF RHEUMATOID ARTHRITIS
First Clinical Medical College, Yunnan University of Chinese Medicine, Kunming, Yunnan, China; Joint Graduate School of Traditional Chinese Medicine of China, Suzhou, China
·
Rheumatology
· 2026
· 16 pages
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by persistent synovitis and progressive joint destruction. This review synthesizes recent advances in the interconnected network involving immune dysregulation, metabolic reprogramming, and aberrant mechanotransduction in RA pathogenesis.
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Clinical reviews
IMMUNOTHERAPY FOR ASTHMA
Hamida Hammad, Engi Ahmed, Bart N. Lambrecht
·
Pulmonology
· 2025
· 12 pages
This review explores the immunological mechanisms underlying various asthma endotypes and provides an overview of the immunotherapies currently available for asthmatic patients, along with their clinical efficacy.
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Clinical reviews
ANTIARRHYTHMIC DRUG THERAPY FOR ACUTE MANAGEMENT OF ATRIAL FIBRILLATION AND ATRIAL FLUTTER
Mohammadali Habibi, MD; Muhammed Rahim, MD; Suneet Mittal, MD
·
Cardiology
· 9 pages
This document discusses the management of acute atrial fibrillation (AF) and atrial flutter (AFL) through antiarrhythmic drug therapy, emphasizing the importance of rate and rhythm control.
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Clinical reviews
VALVULAR HEART FAILURE DUE TO TRICUSPID REGURGITATION SURGICAL AND TRANSCATHETER MANAGEMENT OPTIONS
Columbia University
·
Cardiology
· 15 pages
This document discusses the surgical and transcatheter management options for valvular heart failure due to tricuspid regurgitation, highlighting the importance of understanding the condition's etiology and treatment strategies.
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Clinical reviews
RENAL TRANSPLANTATION
St James's Hospital, Leeds, UK
·
Nephrology
· 2022
· 12 pages
This document discusses renal transplantation as the preferred treatment for kidney failure, highlighting its benefits, challenges, and advancements in the field.
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Clinical reviews
WITHDRAWAL OF PHARMACOLOGICAL TREATMENT FOR HEART FAILURE IN PATIENTS WITH RECOVERED DILATED CARDIOMYOPATHY (TRED-HF): AN OPEN-LABEL, PILOT, RANDOMISED TRIAL
Royal Brompton and Harefield NHS Foundation Trust, London, UK
·
Cardiology
· 13 pages
This document presents a pilot randomized trial examining the safety and effects of withdrawing heart failure medications in patients with recovered dilated cardiomyopathy.
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Clinical reviews
SAFEGUARDING THE KIDNEY
Michael Eisenstein
·
Nephrology
· 2 pages
This document discusses acute kidney injury (AKI), emphasizing the importance of early detection and treatment to prevent long-term health effects. It explores the mechanisms of kidney function and the implications of nephron damage.
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Clinical reviews
A COMPREHENSIVE REVIEW OF DIETARY SUPPLEMENTS MISSION-SPECIFIC HEALTH AND PERFORMANCE ENHANCEMENT IN MILITARY SOLDIERS
The Korean Society of Food Science and Technology
·
Nutrition
· 2024
· 16 pages
This document reviews the role of dietary supplements in enhancing health and performance among military soldiers, addressing health issues arising from high physical and mental stress.
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Clinical reviews
CARDIAC TUMORS: DIAGNOSIS, PROGNOSIS, AND TREATMENT
Rossana Bussani, Matteo Castrichini, Luca Restivo, Enrico Fabris, Aldostefano Porcari, Federico Ferro, Alberto Pivetta, Renata Korcova, Chiara Cappelletto, Paolo Manca, Vincenzo Nuzzi, Riccardo Bessi, Linda Pagura, Laura Massa, Gianfranco Sinagra
·
Cardiology
· 2020
· 13 pages
This document provides an overview of cardiac tumors, discussing their epidemiology, imaging, histopathology, diagnostic workup, treatment, and prognoses. It highlights the challenges in diagnosing and managing these rare tumors.
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Clinical reviews
WORSENING OF CHRONIC HEART FAILURE: DEFINITION, EPIDEMIOLOGY, MANAGEMENT AND PREVENTION. A CLINICAL CONSENSUS STATEMENT BY THE HEART FAILURE ASSOCIATION (HFA) OF THE ESC
Heart Failure Association of the European Society of Cardiology
·
Cardiology
· 2023
· 39 pages
This document provides a comprehensive consensus statement on the definition, epidemiology, management, and prevention of worsening chronic heart failure, developed by the Heart Failure Association of the European Society of Cardiology.
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Clinical reviews
INTRACEREBRAL HEMORRHAGE
Wendy C. Ziai, MD, MPH; Vishank A. Shah, MD
·
Neurology
· 2026
· 33 pages
This review article discusses the primary and secondary prevention of spontaneous intracerebral hemorrhage (ICH), focusing on recovery and rehabilitation nuances for survivors.
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Clinical reviews
RANDOMIZED, CONTROLLED CLINICAL TRIAL OF THE DIALIVE LIVER DIALYSIS DEVICE VERSUS STANDARD OF CARE IN PATIENTS WITH ACUTE ON-CHRONIC LIVER FAILURE
Journal of Hepatology
·
Hepatology
· 2023
· 34 pages
This research article presents a randomized controlled trial assessing the safety and clinical effects of the DIALIVE liver dialysis device in patients with acute-on-chronic liver failure.
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Clinical reviews
STENOTROPHOMONAS MALTOPHILIA INFECTIONS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF COMPARATIVE EFFICACY OF AVAILABLE TREATMENTS, WITH CRITICAL ASSESSMENT OF NOVEL THERAPEUTIC OPTIONS
Cotugno Hospital, University of Naples Federico II, University of Bari
·
Infectious Diseases
· 2023
· 26 pages
This systematic review and meta-analysis evaluates the comparative efficacy of available treatments for Stenotrophomonas maltophilia infections, highlighting the challenges posed by this pathogen's resistance profile.
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Clinical reviews
ACUTE MITRAL REGURGITATION
Miyazaki Medical Association Hospital Cardiovascular Center
·
Cardiology
· 2019
· 7 pages
This document discusses the diagnosis and management of acute mitral regurgitation (MR), highlighting the differences from chronic MR and the challenges in treatment based on various aetiologies.
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Clinical reviews
THROMBOTIC AND BLEEDING COMPLICATIONS DURING ANTITHROMBOTIC TREATMENT: THE NEED FOR NEW THERAPEUTIC TARGETS
Department of Cardiovascular Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Department of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Rome, Italy
·
Cardiology
· 4 pages
This document discusses the significant advancements in pharmacological management for cardiovascular disease patients using antithrombotic agents, while highlighting the persistent risks of bleeding complications.
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Clinical reviews
DIAGNOSIS AND TREATMENT OF ORTHOSTATIC HYPOTENSION
Wouter Wieling, Horacio Kaufmann, Victoria E Claydon, Veera K van Wijnen, Mark P M Harms, Stephen P Juraschek, Roland D Thijs
·
Neurology
· 2022
· 12 pages
This document discusses orthostatic hypotension, characterized by a significant drop in blood pressure upon standing, and its various clinical presentations and management strategies. It emphasizes the importance of individualized, non-pharmacological approaches alongside pharmacological treatments when necessary.
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Clinical reviews
HOW TO IMPROVE THE EFFICIENCY AND THE SAFETY OF REAL - TIME ULTRASOUND - GUIDED CENTRAL VENOUS CATHETERIZATION IN 2023: A NARRATIVE REVIEW
N. Boulet, L. Muller, C. M. Rickard, J. Y. Lefrant, C. Roger
·
Intensive Care
· 2023
· 10 pages
This narrative review synthesizes current knowledge on evidence-based best practices for central venous catheterization (CVC) that enhance the use and feasibility of real-time ultrasound guided insertion procedures.
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Clinical reviews
KIDNEY PROTECTION WITH CANAGLIFLOZIN: A COMBINED ANALYSIS OF THE RANDOMIZED CANVAS PROGRAM AND CREDENCE TRIALS
Toronto General Hospital Research Institute, University Health Network, The George Institute for Global Health, Royal North Shore Hospital, New Arch Consulting, Janssen, Inc.
·
Nephrology
· 2023
· 9 pages
This study analyzes the kidney protection provided by canagliflozin, a sodium glucose co-transporter 2 inhibitor, across various kidney parameters in patients with type 2 diabetes. It is based on a pooled analysis of the CANVAS Program and CREDENCE trials.
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Clinical reviews
HEART FAILURE WITH IMPROVED EJECTION FRACTION
American College of Cardiology Foundation
·
Cardiology
· 2025
· 15 pages
This document provides an in-depth evaluation of heart failure with improved ejection fraction (HFimpEF), including its epidemiology, pathophysiology, prognosis, and treatment strategies.
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