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Clinical reviews
UNDERSTANDING VANCOMYCIN NEPHROTOXICITY AUGMENTED BY β-LACTAMS
Wayne State University, University of California San Diego, Nestlé Health Science
PDF202310 pages522 KB
The recent understanding that hydrophobic β-lactams have greater affinity for organic anion transporter-3 (OAT-3) of the proximal renal tubule could provide valuable insights for anticipating β-lactams that may exacerbate vancomycin-induced nephrotoxicity. Vancomycin alone induces oxidative stress on proximal tubular cells, and the addition of certain β-lactams may increase this stress due to their enhanced uptake. This review synthesizes current knowledge on the interplay between these antibiotics and their nephrotoxic potential, highlighting the multifactorial nature of the associated risks.
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