RECESS TERM LECTURE SICKLE CELL ANEMIA 20 1 2021

Hematology

This document provides a comprehensive overview of Sickle Cell Anemia (SCA), tracing its historical discovery and origins, particularly in Africa. It explains the genetic basis of SCA, stemming from a mutation in the globin gene leading to abnormal hemoglobin. The text then delves into the principles and types of screening programs, including mass/universal and targeted screening, and discusses various investigation methods such as peripheral blood film, High-Performance Liquid Chromatography (HPLC), Isoelectric Focusing (IEF), and Hemoglobin Electrophoresis, noting their applicability and cost-effectiveness in different resource settings.