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Clinical notes
preview-9781840765533 A37686089
General Medicine
PDF201923 pages60.2 MB
The text explains that interferons (IFNα, IFNβ, IFNγ) are primarily produced by leukocytes and fibroblasts, with antiviral effects mediated by protein kinase production. IFNγ is produced by T lymphocytes and natural killer cells, activating macrophages and promoting B-cell IgG production. Tumor necrosis factor (TNFα) is identified as a central mediator of inflammatory changes following bacterial lipopolysaccharide release, sharing features with IL-1 and enhancing macrophage and polymorph chemotaxis. Side effects of interferon therapy include myelosuppression, hypotension, cardiac arrhythmias, and pulmonary infiltrates.
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