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Cynthia T. Nguyen, PharmD; Adam S. Cifu, MD; David Pitrak, MD
The prevention and treatment of Lyme disease varies depending on the clinical presentation. Antibiotic therapy remains the cornerstone of management; however, robust data demonstrating the most efficacious and cost-effective antibiotic, dose, route, and duration are limited. The guideline recommends personal protective measures and timely antibiotic prophylaxis after high-risk tick bites. It also addresses treatment protocols for erythema migrans and Lyme neuroborreliosis, highlighting the need for careful consideration of antibiotic use to avoid overprescribing.
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