Pharmacotherapy of infective endocarditis final

Nachwera Peter

Infective endocarditis (IE) is a life‑threatening infection of the heart valves and endocardial surfaces, with high morbidity and mortality worldwide. The deck outlines the epidemiology, shifting microbiology, and pathophysiological mechanisms underlying IE. It details the pharmacology of key antibiotics, dosing regimens, therapeutic monitoring, and drug‑interaction considerations. Adjunctive therapies such as corticosteroids, hemodynamic support, and management of sepsis are also discussed, along with special scenarios like prosthetic valve endocarditis and intravenous drug use. Learning objectives focus on mechanisms of action, PK/PD principles, and strategies to mitigate adverse effects.