Haschek and Rousseaux's Handbook of Toxicologic Pathology Volume (2)

Wanda M. Haschek, Colin G. Rousseaux, Matthew A. Wallig, Brad Bolon, Kathleen M. Heinz-Tahney, Daniel G. Rudmann, Beth W. Mahler

This handbook, Volume II of the Fourth Edition, delves into the critical field of toxicologic pathology as applied to safety assessment. It highlights the evolution of techniques like bioimaging for real-time monitoring of drug effects in vivo. The text emphasizes the need for pathologists to utilize new tools to understand and manage potential risks associated with novel drug modalities and formulations. It details how to characterize the full spectrum of host responses, from initial gene expression changes to intermediate and final metabolites, correlating these with drug exposure and dose-response relationships.