DISCORDANCE ANALYSES COMPARING LDL CHOLESTEROL, NON-HDL CHOLESTEROL, AND APOB FOR CARDIOVASCULAR RISK ESTIMATION

Camilla Ditlev Lindhardt Johannesen, Martin Bødtker Mortensen, Børge Grønne Nordestgaard, Anne Langsted

Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of morbidity and mortality globally, and identifying the most effective cholesterol marker for assessing risk has been a long-standing challenge. This document focuses on discordance analyses, which examine the discrepancies between different cholesterol markers, namely LDL cholesterol, non-HDL cholesterol, and apolipoprotein B. The authors review various methodologies for defining discordance and present evidence on how these discordances relate to ASCVD risk, highlighting the clinical significance of their findings.