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Case scenarios
Clinical pharmacokinetics and drug dosing
AHMED M. ABDELHADY; DUSTIN SPENCER; BRIAN R. OVERHOLSER
PDF641 pages13.7 MB
The document delves into the pharmacokinetics and pharmacodynamics of antiarrhythmic drugs, starting with amiodarone's classification, electrophysiological effects, and indications for treating ventricular arrhythmias and atrial fibrillation. It then transitions to lidocaine, discussing population-based dosing parameters, adjustments for disease states like heart failure and liver dysfunction, and various traditional and alternative dosing regimens. Finally, it presents case studies on calculating maintenance doses for drugs like procainamide, considering patient-specific pharmacokinetic parameters and potential drug interactions that can affect drug levels.
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