Antibiotics - Gualerzi - 2014

University of Camerino

The volume, edited by Claudio O. Gualerzi, Letizia Brandi, Attilio Fabbretti, and Cynthia L. Pon, presents detailed analyses of bacterial targets such as FtsZ, riboswitches, and enzymes involved in cell wall synthesis. It includes experimental data on novel inhibitor libraries, including benzamide and benzimidazole compounds, and evaluates their efficacy in vitro and in animal models. The text also explores the structural requirements for binding to class I and class II riboswitches and discusses the implications for broad‑spectrum antibiotic development. Throughout, the authors integrate insights from chemical biology, microbiology, and drug discovery to illustrate current challenges and future directions in combating antibiotic resistance.