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Sepsis & Septic Shock

Surviving Sepsis guidance, lactate, cultures, fluids vs vasopressors, adjunctive pressors, steroids and source control.

12 resources

Resources in this collection

This collection provides resources on the management of sepsis and septic shock, focusing on guidelines, treatment strategies, and the use of lactate levels. It is intended for clinicians and students seeking to understand the latest practices in sepsis care.

National and international guidance

01Guidelines & protocolsSURVIVING SEPSIS CAMPAIGN: INTERNATIONAL GUIDELINES FOR MANAGEMENT OF SEPSIS AND SEPTIC SHOCK 2021CanadaCritical Care Medicine· 2021· 81 pagesThis document provides guidelines for the management of sepsis and septic shock in adult patients, emphasizing the importance of early identification and appropriate management.Start here — Surviving Sepsis 2021
02Clinical reviews2023 Update on Sepsis and Septic Shock in Adult Patients: Management in the Emergency DepartmentDepartment of Translational Medicine, St. Anna University Hospital of Ferrara, University of FerraraEmergency Medicine· 2023· 23 pagesThis review aims to update physicians on the main pillars of treatment for sepsis and septic shock, including empirical antimicrobial treatment, fluid replacement, and vasoactive agents. The management of sepsis and septic shock has significantly progressed in the last few years, and improving knowledge of the main therapeutic cornerstones is crucial to achieve better patient outcomes.2023 ED update
03Guidelines & protocolsPROVISION AND RATIONAL USE OF BLOOD CULTURE BOTTLES TO IMPROVE SEPSIS AND BLOODSTREAM INFECTION DIAGNOSISMinistry of Health, UgandaInfectious Disease· 2025· 2 pagesThis document outlines the guidelines for the appropriate use of blood culture bottles to enhance the diagnosis of sepsis and bloodstream infections in Uganda. It emphasizes the importance of timely and accurate diagnosis to improve patient outcomes.Blood cultures done right

Further clinical reference

04Clinical reviewsSEPTIC SHOCK: CURRENT OPINION IN CRITICAL CAREWashington UniversityCritical Care· 2026· 8 pagesThis review aims to provide a summary of recent updates in resuscitation and vasopressor strategies for septic shock, as well as advancements in precision therapy.Read: p. 1Current opinion in critical care
05Clinical reviewsCURRENT PRACTICE AND EVOLVING CONCEPTS IN SEPTIC SHOCK RESUSCITATIONnullIntensive Care· 2021· 16 pagesThis narrative review discusses the advancements in the clinical and pathophysiological understanding of septic shock, focusing on current standards and evolving concepts in resuscitation.Read: Current practice · pp. 1–2Resuscitation — evolving concepts
06Clinical reviewsVASOPRESSORS OR FLUIDS IN EARLY SEPTIC SHOCKThe ARISE FLUIDS Investigators, the ANZICS Clinical Trials Group, and the ACEM Clinical Trials NetworkCritical Care Medicine· 2026· 12 pagesThis study investigates the optimal approach to early resuscitation in septic shock, comparing the use of vasopressors with restricted fluid volumes against higher fluid volumes with later vasopressor therapy.Read: pp. 11–12Vasopressors or fluids first?
07Clinical reviewsHOW TO USE LACTATE LEVELS TO GUIDE SEPTIC SHOCK RESUSCITATION: AN UPDATEErasmus MC University Medical Center, Bloomsbury Institute of Intensive Care MedicineIntensive Care Medicine· 4 pagesThis document provides an update on the use of lactate levels in guiding resuscitation efforts for patients experiencing septic shock. It emphasizes the importance of considering lactate levels alongside other physiological variables rather than in isolation.Read: pp. 3–4Lactate-guided resuscitation
08Clinical reviewsFLUID THERAPY FOR CRITICALLY ILL ADULTS WITH SEPSISFernando G. Zampieri, MD, PhD; Sean M. Bagshaw, MD, MSc; Matthew W. Semler, MD, MScCritical Care Medicine· 14 pagesThis review discusses the importance of fluid therapy in the management of sepsis in critically ill adults, detailing the phases of fluid therapy and its impact on patient outcomes.Read: SHOCK · p. 9Fluid therapy in sepsis

Also in this collection

09Clinical notesHOW WE ESCALATE VASOPRESSOR AND CORTICOSTEROID THERAPY IN PATIENTS WITH SEPTIC SHOCKBoston UniversityCritical Care Medicine· 2023· 8 pagesThis document discusses the escalation of vasopressor and corticosteroid therapy in patients experiencing septic shock, emphasizing treatment decisions and monitoring strategies.Escalating vasopressors & steroids
10Clinical reviewsADJUNCTIVE VASOPRESSORS IN DISTRIBUTIVE SHOCK: HOW SOON IS EARLY?Bruno Garcia and Matthieu LegrandCritical Care Medicine· 3 pagesThis document discusses the timing and administration strategies of adjunctive vasopressors in patients with distributive shock, particularly focusing on the evidence surrounding early versus late administration.Adjunctive vasopressors — how early?
11Clinical reviewsVASOPRESSOR WEANING IN SEPTIC SHOCK: THE MISSING PIECE IN THE 2026 GUIDELINESFederal University of Rio Grande do Sul (UFRGS), Porto Alegre, BrazilCritical Care Medicine· 2026· 2 pagesThis correspondence discusses the gaps in the 2026 Surviving Sepsis Campaign guidelines regarding the de-escalation of vasopressors during septic shock stabilization. It highlights the need for further research on the optimal strategies for vasopressor withdrawal.Vasopressor weaning
12Clinical reviewsEVALUATION OF HYDROCORTISONE, VITAMIN C, AND THIAMINE FOR THE TREATMENT OF SEPTIC SHOCK: A RANDOMIZED CONTROLLED TRIAL (THE HYVITS TRIAL)Saint Luke’s Hospital of Kansas City; Hamad General Hospital, Hamad Medical Corporation; Weill Cornell Medicine-Qatar; Al Wakra Hospital, Hamad Medical Corporation; University of North Carolina Rex Hospital; Penn State Health Milton S. Hershey MedicalCritical Care Medicine· 2023· 5 pagesThis study evaluates the effect of combined hydrocortisone, vitamin C, and thiamine on patients with septic shock in a randomized controlled trial format.Hydrocortisone–vitamin C–thiamine trial

Collection updated Sep 2026· Access follows each resource's usual availability.

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