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Resources
24 shown
Clinical reviews
A BROAD SPECTRUM OF POSSIBILITIES: SPECTRUM SCORES AS A UNIFYING METRIC OF ANTIBIOTIC UTILIZATION
Mayo Clinic Arizona; Mayo Clinic, Rochester, MN
·
Infectious Diseases
· 13 pages
This document discusses the concept of spectrum scoring as a metric for antibiotic utilization, emphasizing its potential advantages over traditional metrics like days of therapy (DOT). It explores the application of spectrum scores in antimicrobial stewardship and patient care.
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Clinical reviews
THERAPEUTICS FOR VANCOMYCIN-RESISTANT ENTEROCOCCAL BLOODSTREAM INFECTIONS
The Alfred Hospital and Monash University, Melbourne, Victoria, Australia
·
Infectious Diseases
· 33 pages
This document provides an overview of the therapeutic options available for treating bloodstream infections caused by vancomycin-resistant enterococci (VRE). It discusses the microbiology, epidemiology, risk factors, and clinical outcomes associated with VRE infections.
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Clinical reviews
RHEUMATOID ARTHRITIS — COMMON ORIGINS, DIVERGENT MECHANISMS
Brigham and Women’s Hospital, Boston; University of California San Diego School of Medicine, La Jolla
·
Rheumatology
· 2023
· 14 pages
This review article discusses rheumatoid arthritis, focusing on its common origins and the divergent mechanisms involved in its pathogenesis. It highlights the role of genetic factors and environmental exposures in the disease's progression.
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Clinical reviews
DENGUE
Centers for Disease Control and Prevention, San Juan, Puerto Rico; Institute of Child Health and Human Development, National Institutes of Health, University of the Philippines, Manila
·
Infectious Diseases
· 2024
· 16 pages
Dengue, caused by four closely related viruses, is a growing global public health concern, with outbreaks capable of overwhelming health-care systems and disrupting economies.
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Clinical reviews
NEW DRUG THERAPIES FOR HYPERTENSION
INSERM CIC1418, Hôpital Européen Georges Pompidou, APHP, Université Paris Cité, University of Washington
·
Cardiology
· 2026
· 15 pages
This document discusses emerging antihypertensive drug therapies that target physiological pathways beyond conventional drug classes, addressing the need for innovative approaches in hypertension care.
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Clinical reviews
ANTIMICROBIAL THERAPY FOR VRE BLOODSTREAM INFECTIONS
Department of Infectious Diseases, The Alfred Hospital and Central Clinical School, Monash University, Melbourne, Victoria, Australia
·
Infectious Diseases
· 33 pages
This document reviews the therapeutic options for managing bloodstream infections caused by vancomycin-resistant Enterococcus (VRE), highlighting the challenges and advancements in treatment strategies.
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Clinical reviews
REDUCING POST-CESAREAN SEPSIS: CURRENT BEST PRACTICE IN PREVENTION AND TREATMENT
International Federation of Gynecology and Obstetrics (FIGO)
·
Obstetrics and Gynecology
· 2025
· 11 pages
This article discusses the current best practices for preventing and treating post-cesarean sepsis, emphasizing evidence-based recommendations.
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Clinical reviews
EFFICACY OF GREATER OCCIPITAL NERVE BLOCK FOR PAIN RELIEF IN PATIENTS WITH POSTDURAL PUNCTURE HEADACHE
Ying-Jen Chang, MD, Kuo-Chuan Hung, MD, I-Wen Chen, MD, Chi-Lin Kuo, MD, I-Chia Teng, MD, Ming-Chung Lin, MD, Ming Yew, MD, Shu-Wei Liao, MD, Chung-Yi Wu, MD, Chia-Hung Yu, MD, Kuo-Mao Lan, MD, Cheuk-Kwan Sun, MD, PhD
·
Anesthesiology
· 2021
· 9 pages
This systematic review and meta-analysis assesses the therapeutic effectiveness of greater occipital nerve block (GONB) for alleviating postdural puncture headache (PDPH). It evaluates various studies to determine the analgesic effects of GONB in adult patients.
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Clinical reviews
DIRECT ORAL ANTICOAGULANTS VERSUS WARFARIN IN PATIENTS WITH NON-VALVULAR ATRIAL FIBRILLATION AND CKD G3–G5D
Umeå University, Uppsala University
·
Cardiology
· 10 pages
This study investigates the risk of ischemic stroke and major bleeding in patients with non-valvular atrial fibrillation and chronic kidney disease treated with direct oral anticoagulants compared to warfarin.
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Clinical notes
A GUIDE TO ENTERAL NUTRITION IN INTENSIVE CARE UNITS: 10 EXPERT TIPS FOR THE DAILY PRACTICE
Jean-Charles Preiser, Yaseen M. Arabi, Mette M. Berger, Michael Casaer, Stephen McClave, Juan C. Montejo-González, Sandra Peake, Annika Reintam Blaser, Greet Van den Berghe, Arthur van Zanten, Jan Wernerman, Paul Wischmeyer
·
Critical Care Medicine
· 13 pages
This article provides practical guidance on enteral nutrition in critically ill patients, emphasizing the importance of the oral/enteral route over gut rest. It outlines recommendations for starting enteral nutrition and managing potential complications.
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Clinical reviews
CUTANEOUS DRUG-INDUCED LUPUS ERYTHEMATOSUS: CLINICAL AND IMMUNOLOGICAL CHARACTERISTICS AND UPDATE ON NEW ASSOCIATED DRUGS
Service de dermatologie et allergologie, faculté de médecine Sorbonne Université, Hôpital Tenon, AP–HP, Paris, France
·
Dermatology
· 2021
· 10 pages
This review discusses cutaneous drug-induced lupus erythematosus (CDILE), focusing on its clinical and laboratory aspects, pathogenesis, and an update on drugs associated with the condition.
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Guidelines & protocols
Management of hypertensive crisis: British and Irish Hypertension Society Position document
British and Irish Hypertension Society
·
Cardiology
· 2022
· 17 pages
This position paper provides a framework for diagnosing, evaluating, and managing patients with hypertensive crisis, based on critical appraisal of available evidence and expert opinion.
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Clinical reviews
CARDIOVASCULAR DISEASE IN WOMEN: DO WE NEED NEW DIAGNOSTIC AND THERAPEUTIC STRATEGIES?
Clinico San Carlos University Hospital, Hospital de la Santa Creu i Sant Pau, Universitary Hospital Fundación Alcorcón, La Paz University Hospital, Universidad Europea de Madrid, Universitary Hospital Santiago de Compostela, University Hospital Vall
·
Cardiology
· 12 pages
This review discusses the underrecognition and undertreatment of cardiovascular disease in women compared to men, highlighting the need for new diagnostic and therapeutic strategies.
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Clinical reviews
USE OF HYPERTONIC SALINE IN NEUROANESTHESIA AND NEUROCRITICAL CARE PRACTICE: A NARRATIVE REVIEW
Postgraduate Institute of Medical Education and Research, Chandigarh, India
·
Neuroanesthesia
· 2023
· 9 pages
This narrative review evaluates the use of hypertonic saline (HTS) in neuroanesthesia and neurocritical care, focusing on its mechanisms and clinical applications.
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Clinical reviews
NEWLY DIAGNOSED HEART FAILURE WITH REDUCED EJECTION FRACTION: TIMING, SEQUENCING, AND TITRATION OF GUIDELINE-RECOMMENDED MEDICAL THERAPY
Erasmus MC, Maastricht University Medical Centre, Ikazia Ziekenhuis, Meander Medical Centre, Noordwest Hospital Group, Haaglanden Medical Centre, Amphia Ziekenhuis, Dutch Network for Cardiovascular Research, Zuyderland Medisch Centrum, Medisch Spectrum
·
Cardiology
· 2025
· 12 pages
This document discusses the timing, sequencing, and titration of guideline-recommended medical therapy for newly diagnosed heart failure with reduced ejection fraction.
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Guidelines & protocols
EUROPEAN SOCIETY OF ENDOCRINOLOGY AND ENDOCRINE SOCIETY JOINT CLINICAL GUIDELINE: DIAGNOSIS AND THERAPY OF GLUCOCORTICOID-INDUCED ADRENAL INSUFFICIENCY
University of Zürich, Ludwig-Maximilians-Universität, University of Michigan, Mayo Clinic, University Hospital Würzburg, University of Texas Southwestern Medical Center, Leiden University Medical Center, University of Bergen, University of Birmingham
·
Endocrinology
· 27 pages
This guideline provides recommendations for the diagnosis and management of glucocorticoid-induced adrenal insufficiency, addressing various clinical aspects including patient monitoring and testing protocols.
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Clinical reviews
HOW TO RECOGNIZE A TRUSTWORTHY CLINICAL PRACTICE GUIDELINE
João Pedro Lima, Reza D. Mirza, Gordon H. Guyatt
·
General Medicine
· 7 pages
This document outlines the criteria for evaluating the trustworthiness of clinical practice guidelines, emphasizing the importance of evidence-based recommendations in clinical decision-making.
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Clinical reviews
CHRONIC KIDNEY DISEASE AND CORONARY ARTERY DISEASE
American College of Cardiology
·
Cardiology
· 2019
· 16 pages
Chronic kidney disease (CKD) is a major risk factor for coronary artery disease (CAD), complicating its management due to the presence of traditional and nontraditional cardiovascular risk factors.
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Clinical reviews
ANTIPSYCHOTIC MEDICATION INFLUENCES THE DISCRIMINATIVE VALUE OF ACYLETHANOLAMIDES AS BIOMARKERS OF SUBSTANCE USE DISORDER
Grupo de Neuropsicofarmacología, IBIMA-Plataforma BIONAND, Hospital Regional Universitario de Málaga, Universidad de Málaga
·
Psychiatry
· 2023
· 16 pages
This article explores how antipsychotic medication affects the levels of acylethanolamides, which may serve as biomarkers for substance use disorders. It discusses the implications of these findings for understanding the relationship between psychiatric medications and substance use disorders.
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Clinical reviews
CONTEMPORARY MANAGEMENT OF MAJOR HAEMORRHAGE IN CRITICAL CARE
Springer-Verlag GmbH Germany, part of Springer Nature
·
Critical Care Medicine
· 2024
· 13 pages
This review discusses the complexities of managing critically ill patients experiencing major haemorrhage, emphasizing the importance of rapid treatment and individualized management protocols.
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Clinical reviews
GREAT DEBATE: CLOPIDOGREL SHOULD NOW REPLACE ASPIRIN FOR LONG-TERM SECONDARY PREVENTION OF CORONARY ARTERY DISEASE
University of Glasgow, Cardiocentro Ticino Institute, University of Bern, Catholic University School of Medicine, University of Campania 'Luigi Vanvitelli', Imperial College London, East and North Hertfordshire NHS Trust, Royal Brompton Hospital
·
Cardiology
· 14 pages
This document discusses the debate surrounding the use of clopidogrel versus aspirin for long-term secondary prevention of coronary artery disease (CAD). It presents evidence suggesting that clopidogrel may offer superior ischemic protection without the bleeding risk associated with aspirin.
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Clinical reviews
RHEUMATOID ARTHRITIS IN ADULTS
JAMA
·
Rheumatology
· 2026
· 15 pages
This document provides a comprehensive review of rheumatoid arthritis (RA), a chronic autoimmune disease that leads to inflammation and destruction of cartilage and adjacent bone, potentially resulting in irreversible disability.
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Clinical reviews
RENAL THROMBOTIC MICROANGIOPATHY: A REVIEW
null
·
Nephrology
· 2022
· 15 pages
This review discusses thrombotic microangiopathy (TMA), a pathological lesion observed in various diseases, particularly focusing on renal-limited forms of TMA. It highlights the clinical presentation, diagnostic challenges, and treatment strategies for TMA involving the kidney.
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Clinical reviews
PRACTICAL IMPLICATIONS OF THE GN-AC MATRIX AND RESEARCH PERSPECTIVES
Department of Experimental and Biomedical Sciences 'Mario Serio', Meyer Children's University Hospital, Florence, Italy; Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia;
·
Nephrology
· 2023
· 17 pages
This document discusses the classification of glomerulonephritis (GN) by pathogenesis, activity, and chronicity, emphasizing the importance of understanding these classifications for treatment decisions.
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