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Resources
24 shown
Guidelines & protocols
AGA CLINICAL PRACTICE UPDATE ON THE PERSONALIZED APPROACH TO THE EVALUATION AND MANAGEMENT OF GERD: EXPERT REVIEW
University of California San Diego School of Medicine; Washington University School of Medicine; Northwestern University Feinberg School of Medicine
·
Gastroenterology
· 2022
· 12 pages
This clinical practice update outlines a personalized diagnostic and therapeutic approach to gastroesophageal reflux disease (GERD) symptoms, emphasizing the need for individualized care plans.
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Clinical reviews
STENOTROPHOMONAS MALTOPHILIA INFECTIONS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF COMPARATIVE EFFICACY OF AVAILABLE TREATMENTS, WITH CRITICAL ASSESSMENT OF NOVEL THERAPEUTIC OPTIONS
Cotugno Hospital, University of Naples Federico II, University of Bari
·
Infectious Diseases
· 2023
· 26 pages
This systematic review and meta-analysis evaluates the comparative efficacy of available treatments for Stenotrophomonas maltophilia infections, highlighting the challenges posed by this pathogen's resistance profile.
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Clinical reviews
ACUTE MITRAL REGURGITATION
Miyazaki Medical Association Hospital Cardiovascular Center
·
Cardiology
· 2019
· 7 pages
This document discusses the diagnosis and management of acute mitral regurgitation (MR), highlighting the differences from chronic MR and the challenges in treatment based on various aetiologies.
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Clinical notes
RAPID PAEDIATRICS AND CHILD HEALTH
Helen A. Brough, Ram Nataraja
·
Paediatrics
· 2010
· 281 pages
This document serves as a comprehensive guide to paediatrics and child health, covering various clinical conditions and their management.
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Clinical reviews
THROMBOTIC AND BLEEDING COMPLICATIONS DURING ANTITHROMBOTIC TREATMENT: THE NEED FOR NEW THERAPEUTIC TARGETS
Department of Cardiovascular Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Department of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Rome, Italy
·
Cardiology
· 4 pages
This document discusses the significant advancements in pharmacological management for cardiovascular disease patients using antithrombotic agents, while highlighting the persistent risks of bleeding complications.
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Clinical reviews
DIAGNOSIS AND TREATMENT OF ORTHOSTATIC HYPOTENSION
Wouter Wieling, Horacio Kaufmann, Victoria E Claydon, Veera K van Wijnen, Mark P M Harms, Stephen P Juraschek, Roland D Thijs
·
Neurology
· 2022
· 12 pages
This document discusses orthostatic hypotension, characterized by a significant drop in blood pressure upon standing, and its various clinical presentations and management strategies. It emphasizes the importance of individualized, non-pharmacological approaches alongside pharmacological treatments when necessary.
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Guidelines & protocols
KDIGO 2023 CLINICAL PRACTICE GUIDELINE FOR THE MANAGEMENT OF ANTINEUTROPHIL CYTOPLASMIC ANTIBODY (ANCA)-ASSOCIATED VASCULITIS
Kidney Disease: Improving Global Outcomes (KDIGO)
·
Rheumatology
· 2023
· 63 pages
This document presents the KDIGO 2023 clinical practice guidelines for managing ANCA-associated vasculitis, detailing recommendations for treatment and management strategies.
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Clinical reviews
HOW TO IMPROVE THE EFFICIENCY AND THE SAFETY OF REAL - TIME ULTRASOUND - GUIDED CENTRAL VENOUS CATHETERIZATION IN 2023: A NARRATIVE REVIEW
N. Boulet, L. Muller, C. M. Rickard, J. Y. Lefrant, C. Roger
·
Intensive Care
· 2023
· 10 pages
This narrative review synthesizes current knowledge on evidence-based best practices for central venous catheterization (CVC) that enhance the use and feasibility of real-time ultrasound guided insertion procedures.
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Clinical reviews
KIDNEY PROTECTION WITH CANAGLIFLOZIN: A COMBINED ANALYSIS OF THE RANDOMIZED CANVAS PROGRAM AND CREDENCE TRIALS
Toronto General Hospital Research Institute, University Health Network, The George Institute for Global Health, Royal North Shore Hospital, New Arch Consulting, Janssen, Inc.
·
Nephrology
· 2023
· 9 pages
This study analyzes the kidney protection provided by canagliflozin, a sodium glucose co-transporter 2 inhibitor, across various kidney parameters in patients with type 2 diabetes. It is based on a pooled analysis of the CANVAS Program and CREDENCE trials.
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Clinical reviews
HEART FAILURE WITH IMPROVED EJECTION FRACTION
American College of Cardiology Foundation
·
Cardiology
· 2025
· 15 pages
This document provides an in-depth evaluation of heart failure with improved ejection fraction (HFimpEF), including its epidemiology, pathophysiology, prognosis, and treatment strategies.
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Clinical reviews
LINERIXIBAT IN PATIENTS WITH PRIMARY BILIARY CHOLANGITIS AND CHOLESTATIC PRURITUS (GLISTEN): A RANDOMISED, MULTICENTRE, DOUBLE-BLIND, PLACEBO-CONTROLLED, PHASE 3 TRIAL
GLISTEN Study Group
·
Gastroenterology
· 2025
· 12 pages
This document presents the findings of a phase 3 trial evaluating the safety and efficacy of linerixibat, an ileal bile acid transporter inhibitor, as a specific antipruritic therapy for patients with primary biliary cholangitis (PBC) and cholestatic pruritus.
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Clinical reviews
Management of Cardiogenic Shock in Patients with Acute Myocardial Infarction
Katherine J. Kunkel, MD, MSEd, Brittany Fuller, MD, Mir B. Basir, DO
·
Cardiology
· 13 pages
This document discusses the management strategies for cardiogenic shock in patients experiencing acute myocardial infarction, emphasizing the importance of early identification and mechanical support.
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Guidelines & protocols
MULTIPLE TRAUMA MANAGEMENT IN MOUNTAIN ENVIRONMENTS - A SCOPING REVIEW
BMC
·
Emergency Medicine
· 2019
· 22 pages
This scoping review provides evidence-based guidance for managing multiple trauma in mountain environments, highlighting the unique challenges and considerations compared to urban settings.
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Clinical reviews
SYSTEMATIC REVIEW AND META-ANALYSIS OF DIAGNOSTIC TEST ACCURACY OF ST-SEGMENT ELEVATION FOR ACUTE CORONARY OCCLUSION
Instituto Dante Pazzanese de Cardiologia, São Paulo, Brazil
·
Cardiology
· 2021
· 7 pages
This systematic review evaluates the diagnostic sensitivity and specificity of ST-segment elevation on a 12-lead ECG in detecting acute coronary occlusion (ACO). It challenges the current STEMI-NSTEMI paradigm by analyzing data from multiple studies.
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Clinical reviews
SYSTEMIC LUPUS ERYTHEMATOSUS IN CRITICAL CARE: A SYSTEMATIC REVIEW OF ICU OUTCOMES AND MANAGEMENT
Edith Ramírez-Lara, Claudia Mendoza-Pinto, Pamela Munguía-Realpozo, Miguel Ángel Saavedra-Salinas, Ivet Etchegaray-Morales, Jorge Ayón-Aguilar, Álvaro José Montiel-Jarquín, Socorro Martínez-Méndez
·
Rheumatology
· 10 pages
This document provides a systematic review of the outcomes and management strategies for patients with systemic lupus erythematosus (SLE) admitted to intensive care units (ICUs). It synthesizes recent evidence on causes of ICU admission, mortality predictors, and therapeutic approaches.
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Guidelines & protocols
AMERICAN SOCIETY OF HEMATOLOGY 2021 GUIDELINES FOR MANAGEMENT OF VENOUS THROMBOEMBOLISM: PREVENTION AND TREATMENT IN PATIENTS WITH CANCER
American Society of Hematology
·
Hematology
· 2021
· 48 pages
This document outlines the clinical guidelines for the management of venous thromboembolism (VTE) in cancer patients, focusing on prevention and treatment strategies.
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Clinical reviews
BEYOND THE 4 PILLARS
Città della Salute e della Scienza Hospital, Turin, Italy
·
Cardiology
· 4 pages
This editorial comment discusses the role of vericiguat in the management of heart failure with reduced ejection fraction (HFrEF), emphasizing its potential benefits and the challenges in treatment outcomes.
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Clinical reviews
ALDOSTERONE SYNTHASE INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASE
Gian Paolo Rossi, Federico Bernardo Rossi, Andrea Cignarella, Teresa Maria Seccia
·
Cardiology
· 2026
· 11 pages
This review discusses the role of aldosterone synthase inhibitors (ASIs) in managing cardiovascular diseases, particularly focusing on their efficacy in lowering aldosterone levels and blood pressure in patients with resistant hypertension.
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Guidelines & protocols
ENHANCED RECOVERY AFTER SURGERY (ERASÒ) SOCIETY CONSENSUS GUIDELINES FOR EMERGENCY LAPAROTOMY PART 3: ORGANIZATIONAL ASPECTS AND GENERAL CONSIDERATIONS FOR MANAGEMENT OF THE EMERGENCY LAPAROTOMY PATIENT
Carol J. Peden, Geeta Aggarwal, Robert J. Aitken, Iain D. Anderson, Angie Balfour, Nicolai Bang Foss, Zara Cooper, Jugdeep K. Dhesi, W. Brenton French, Michael C. Grant, Folke Hammarqvist, Sarah P. Hare, Joaquim M. Havens, Daniel N. Holena, Martin
·
General Surgery
· 2023
· 18 pages
This document presents Part 3 of the consensus guidelines for the optimal care of patients undergoing emergency laparotomy using an enhanced recovery after surgery (ERAS) approach, focusing on organizational aspects of care.
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Clinical reviews
TIME TO MOVE BEYOND THE STATIN NOCEBO EFFECT
Yale School of Medicine
·
Cardiology
· 3 pages
This editorial discusses the challenges associated with statin therapy, particularly the nocebo effect that leads many patients to discontinue their medication despite its proven benefits in cardiovascular prevention.
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Clinical reviews
MAP EGDT DO2 ED SSC VO2 CRT POCUS CCE FR CRT-PHR ICU CVP SOFA
Dr. Luis Tisn
·
Critical Care Medicine
· 2026
· 13 pages
This document discusses the evolution of septic shock management, emphasizing the transition from fixed protocols to personalized, physiology-driven resuscitation strategies.
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Clinical reviews
SGLT2 INHIBITORS AND RISK OF DISTANT METASTASIS IN PATIENTS WITH BREAST CANCER AND TYPE 2 DIABETES: A TARGET TRIAL EMULATION WITH BIOLOGICAL PLAUSIBILITY ANALYSIS
Tri-Service General Hospital, College of Medicine, National Defense Medical University, Taipei, Taiwan
·
Oncology
· 15 pages
This study investigates the association between SGLT2 inhibitor use and the risk of distant metastasis in patients with breast cancer and type 2 diabetes. It employs a target trial emulation methodology to analyze data from a large patient population.
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Clinical reviews
FEMORAL VEIN PULSATILITY: A SIMPLE TOOL FOR VENOUS CONGESTION ASSESSMENT
V. Bhardwaj, P. Rola, A. Denault, G. Vikneswaran, R. Spiegel
·
Cardiology
· 10 pages
This article discusses the use of femoral vein Doppler (FVD) as a simpler alternative to the VExUS score for assessing venous congestion in adult post-cardiac surgery patients.
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Clinical reviews
SAFETY, TOLERABILITY, AND EFFICACY OF UP-TITRATION OF GUIDELINE-DIRECTED MEDICAL THERAPIES FOR ACUTE HEART FAILURE (STRONG-HF): A MULTINATIONAL, OPEN-LABEL, RANDOMISED, TRIAL
Université Paris Cité, INSERM UMR-S 942 (MASCOT), Paris, France
·
Cardiology
· 2022
· 15 pages
This document presents the findings of a multinational trial assessing the safety, tolerability, and efficacy of up-titration of guideline-directed medical therapies in patients with acute heart failure.
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