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Clinical reviews
INVASULAR ULTRASOUND-GUIDED VERSUS ANGIOGRAPHY-GUIDED PERCUTANEOUS CORONARY INTERVENTION IN UNPROTECTED LEFT MAIN CORONARY ARTERY DISEASE: A SYSTEMATIC REVIEW
Cardialysis, Cork University Hospital, Hospital Universitario Marques de Valdecilla, IRCCS Policlinico S. Donato, John Radcliffe Hospital
·
Cardiology
· 10 pages
This systematic review evaluates the evidence on intravascular ultrasound (IVUS) guidance versus angiography guidance in percutaneous coronary interventions (PCI) for unprotected left main coronary artery disease.
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Clinical reviews
CARDIOVASCULAR MAGNETIC RESONANCE TO GUIDE DEFIBRILLATOR IMPLANTATION FOR LVEF OF 36% TO 50%
null
·
Cardiology
· 2023
· 11 pages
This study investigates whether the implantation of implantable cardioverter-defibrillators (ICDs) reduces sudden cardiac death or hemodynamically significant ventricular arrhythmia in patients with a left ventricular ejection fraction of 36% to 50% and myocardial scar.
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Clinical reviews
GENERAL PRINCIPLES AND OVERVIEW OF MANAGEMENT OF RHEUMATOID ARTHRITIS
Larry W Moreland, MD, Amy Cannella, MD, MS, RhMSUS
·
Rheumatology
· 2026
· 44 pages
This document provides an overview of management strategies for patients with rheumatoid arthritis (RA), focusing on controlling synovitis, preventing joint damage, relieving pain, and preserving musculoskeletal function.
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Clinical reviews
LEFLUNOMIDE-HYDROXYCHLOROQUINE COMBINATION THERAPY IN PATIENTS WITH PRIMARY SJÖGREN'S SYNDROME (REPURPSS-I): A PLACEBO-CONTROLLED, DOUBLE-BLINDED, RANDOMISED CLINICAL TRIAL
Utrecht University
·
Rheumatology
· 2020
· 11 pages
This document presents a clinical trial investigating the efficacy of leflunomide-hydroxychloroquine combination therapy in patients with primary Sjögren's syndrome. The study is designed as a placebo-controlled, double-blinded, randomized trial.
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Clinical reviews
COMMUNITY-BASED STRATEGIES TO STRENGTHEN MEN'S ENGAGEMENT IN THE HIV CARE CASCADE IN SUB-SAHARAN AFRICA
University of Washington, Seattle, Washington, United States of America
·
Infectious Diseases
· 2017
· 13 pages
This document discusses community-based strategies aimed at enhancing men's participation in the HIV care cascade in sub-Saharan Africa, addressing barriers and proposing interventions.
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Clinical reviews
WHAT EVERY INTENSIVIST SHOULD KNOW ABOUT MONITORING RESPIRATORY DRIVE AND EFFORT
TechMed Centre, University of Twente; Intensive Care Centre, University Medical Centre Utrecht
·
Intensive Care Medicine
· 4 pages
This document discusses the importance of monitoring respiratory drive and effort in critically ill patients, particularly in the context of mechanical ventilation. It highlights the physiological implications of ventilatory support and the need for tailored monitoring to optimize patient outcomes.
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Clinical reviews
WHAT TO KNOW ABOUT THE NEW BLOOD PRESSURE GUIDELINES
American Heart Association, American College of Cardiology
·
Cardiology
· 2025
· 3 pages
This document discusses the updates in the new high blood pressure guidelines for adults released by the American Heart Association and the American College of Cardiology, emphasizing earlier treatment and tighter control of blood pressure.
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Clinical reviews
PAROXYSMAL ATRIAL FIBRILLATION
UpToDate, Inc.
·
Cardiology
· 2026
· 19 pages
This document provides an overview of paroxysmal atrial fibrillation (PAF), including its management and treatment options.
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Clinical reviews
GLUCOSE AND HEMOGLOBIN A₁C
Department of Clinical Laboratory Sciences, University of Texas Medical Branch, Galveston
·
Endocrinology
· 4 pages
This document provides an overview of glucose metabolism and the significance of Hemoglobin A₁c in monitoring blood glucose levels. It discusses the biochemical pathways involved in glucose regulation and the methods used for measuring HbA₁c.
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Clinical reviews
NEUROVASCULAR DISORDERS IN PREGNANCY: PREVALENCE, CLINICAL ASSESSMENT AND MANAGEMENT—A REVIEW OF THE LITERATURE
University Hospitals Coventry & Warwickshire, Warwick Medical School, University of Warwick
·
Neurology
· 11 pages
This review covers the prevalence, clinical presentation, diagnosis, and management of neurovascular disorders in pregnancy, emphasizing the need for early identification and multidisciplinary care.
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Clinical reviews
ATORVASTATIN, CARDIOVASCULAR EVENTS, AND DISABILITY-FREE SURVIVAL IN OLDER ADULTS
NEJM
·
Cardiology
· 2026
· 13 pages
This study investigates the effectiveness and safety of atorvastatin for the primary prevention of cardiovascular events and the extension of disability-free survival among older adults.
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Clinical reviews
ATRIAL FIBRILLATION: CLINICAL MANIFESTATIONS AND DIAGNOSIS
Kapil Kumar, MD
·
Cardiology
· 2025
· 24 pages
This document provides a comprehensive overview of the clinical presentation and diagnosis of atrial fibrillation (AF), the most common treated cardiac arrhythmia.
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Clinical reviews
TREATMENT AND PREVENTION OF HYPERKALEMIA IN ADULTS
David B Mount, MD
·
Nephrology
· 2026
· 40 pages
This document reviews the treatment and prevention strategies for hyperkalemia, focusing on its causes, diagnosis, and clinical manifestations. It discusses various therapeutic approaches, including the use of diuretics and gastrointestinal cation exchangers.
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Clinical reviews
PREVALENCE, SEVERITY AND FACTORS ASSOCIATED WITH PERIPHERAL NEUROPATHY AMONG NEWLY DIAGNOSED DIABETIC PATIENTS ATTENDING MULAGO HOSPITAL: A CROSS-SECTIONAL STUDY
Department of Medicine, Mulago Hospital; Department of Medicine, School of Medicine, Makerere University; Neurology Institute, University Hospitals Case Medical Center
·
Neurology
· 11 pages
This study aims to determine the prevalence and associated risk factors of diabetic peripheral neuropathy (DPN) among newly diagnosed diabetes mellitus patients in Mulago Hospital.
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Clinical reviews
INTEGRATION OF ALTERNATIVE AND COMPLEMENTARY MEDICINE WITH MODERN WESTERN MEDICINE FOR ENHANCED PATIENT CARE
International Organisation for Integrated Health Practitioners, Royal College of Paediatrics and Child Health
·
Integrative Medicine
· 2024
· 9 pages
This document discusses the integration of alternative and complementary medicine (CAM) with modern Western medicine, highlighting the benefits of combining both approaches for improved patient care.
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Clinical reviews
HYPOCALCEMIA
David Goltzman, MD
·
Endocrinology
· 2026
· 18 pages
This document provides a comprehensive review of hypocalcemia, including its clinical manifestations, diagnostic approaches, and management strategies. It emphasizes the differences in treatment for acute and chronic hypocalcemia.
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Clinical reviews
ANTIBIOTICS MUST BE PART OF END-OF-LIFE DECISIONS: A NECESSARY EVIL?
Iuri Correia, João Gonçalves Pereira, Victoria Metaxa
·
Intensive Care
· 2026
· 3 pages
This document discusses the role of antibiotics in end-of-life care for critically ill patients, highlighting the challenges of antibiotic overuse and the need for better stewardship in intensive care settings.
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Clinical reviews
DEXAMETHASONE IN PATIENTS WITH SPONTANEOUS INTRACEREBRAL HEMORRHAGE: AN UPDATED META-ANALYSIS
Medical University of Varna, Municipal Hospital Landshut, University Erlangen-Nuremberg, University Hospital Erlangen
·
Neurology
· 2023
· 8 pages
This document presents an updated meta-analysis on the effects of dexamethasone in patients with spontaneous intracerebral hemorrhage (ICH), comparing outcomes with control groups. It synthesizes data from randomized clinical trials to evaluate the efficacy of dexamethasone treatment.
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Clinical reviews
ATRIAL FIBRILLATION AND HEART FAILURE: MANAGEMENT
Brian Olshansky, MD
·
Cardiology
· 2025
· 34 pages
This document focuses on the acute and long-term management and prognosis of atrial fibrillation in patients with heart failure, including those with reduced and preserved ejection fraction.
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Clinical reviews
Intracoronary Low-Dose Thrombolysis in Primary PCI for STEM
Kevin R. Bainey, MD, MSc
·
Cardiology
· 2026
· 3 pages
A systematic review and meta-analysis of randomized trials evaluating low‑dose intracoronary thrombolytics during primary percutaneous coronary intervention for ST‑elevation myocardial infarction.
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Clinical reviews
IMPLICATIONS OF THE 2026 DYSLIPIDEMIA GUIDELINE FOR PRIMARY PREVENTION STATIN THERAPY
Timothy S. Anderson, MD, MAS; Linnea M. Wilson, MPH; Jeremy B. Sussman, MD, MS
·
Cardiology
· 2026
· 8 pages
This document assesses the population health impact of the 2026 American Heart Association/American College of Cardiology/multisociety guideline on primary prevention statin therapy, focusing on changes in eligibility for statin therapy among nonpregnant adults aged 30 to 79 years.
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Clinical reviews
ADVANCES IN ISCHEMIC STROKE TREATMENT: CURRENT AND FUTURE THERAPIES
Division of Neurosurgery, Queen Mary Hospital, Hong Kong Hospital Authority; Department of Neurosurgery, Kochi University Hospital, Kochi, Japan
·
Neurology
· 2025
· 14 pages
This review summarizes current concepts in our understanding of stroke anatomy, pathophysiology of cerebral hypoperfusion, and collateral circulation, along with evidence-based updates in stroke trials and treatments.
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Clinical reviews
PERIOPERATIVE CARDIAC ARREST: A RARE EVENT WORTH MEASURING
Department of Anesthesia, The Permanente Medical Group; University of California San Francisco; NIHR Southampton Biomedical Research Centre; University of Southampton
·
Anesthesiology
· 4 pages
This editorial discusses the rarity and severity of perioperative cardiac arrest, particularly in emergency surgery patients, and emphasizes the need for tailored care pathways. It highlights the importance of understanding patient and procedure-level factors to mitigate risks.
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Clinical reviews
CURRENT Diagnosis & Treatment Pediatrics 27th Edition 2025
Lalit Bajaj; AnnChristine Nyquist
·
General Medicine
· 1777 pages
This chapter discusses the evolution of patient safety and quality of care in healthcare systems, referencing key reports that have shaped current practices.
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