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Clinical reviews
EFFICACY AND SAFETY OF EARLY ADMINISTRATION OF 4-FACTOR PROTHROMBIN COMPLEX CONCENTRATE IN PATIENTS WITH TRAUMA AT RISK OF MASSIVE TRANSFUSION
null
·
Emergency Medicine
· 2023
· 9 pages
This study investigates the efficacy and safety of early administration of 4-factor prothrombin complex concentrate (4F-PCC) in trauma patients at risk of massive transfusion.
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Clinical reviews
MANAGEMENT FOR ELECTROLYTES DISTURBANCES DURING CONTINUOUS RENAL REPLACEMENT THERAPY
Sungkyunkwan University School of Medicine, Samsung Medical Center
·
Nephrology
· 2022
· 12 pages
This review article discusses the management of electrolyte disturbances in critically ill patients undergoing continuous renal replacement therapy (CRRT). It highlights the advantages of CRRT in maintaining hemodynamic stability and correcting electrolyte imbalances.
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Clinical reviews
MANAGEMENT OF DIABETIC KETOACIDOSIS IN PREGNANCY
Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, Texas
·
Obstetrics
· 2022
· 10 pages
This document discusses the management of diabetic ketoacidosis (DKA) during pregnancy, highlighting its rarity but potential severity as a complication of diabetes. It emphasizes the importance of early recognition and aggressive treatment to ensure maternal and fetal safety.
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Clinical reviews
MANAGEMENT OF ACUTE LIVER FAILURE IN INTENSIVE CARE
University College London, Royal Free Hospital, Institute of Liver & Digestive Health
·
Intensive Care Medicine
· 2021
· 7 pages
This document discusses the management of acute liver failure (ALF) in intensive care settings, emphasizing the need for a multidisciplinary approach and early referral to liver transplantation centers.
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Clinical reviews
MATERNAL CRITICAL CARE: PART II
Guys and St Thomas’ NHS Foundation Trust, Nottingham University Hospitals NHS Trust
·
Obstetrics
· 2021
· 8 pages
This article discusses the management of pregnancy-specific conditions in critically ill pregnant women, emphasizing the challenges posed by multiple comorbidities and advanced maternal age.
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Clinical reviews
EFFICACY AND SAFETY OF PRASUGREL COMPARED WITH CLOPIDOGREL IN PATIENTS WITH ACUTE CORONARY SYNDROMES: RESULTS OF TRITON-TIMI 38 TRIALS
Dipartimento Cardiovascolare, Ospedale Civile di Legnano, Milan, Italy
·
Cardiology
· 2009
· 7 pages
This document reviews the efficacy and safety of prasugrel compared to clopidogrel in patients with acute coronary syndromes, highlighting the results of the TRITON-TIMI 38 trial.
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Clinical reviews
STATIN INITIATION AND RISK OF INCIDENT KIDNEY DISEASE IN PATIENTS WITH DIABETES
Institute of Nephrology, Affiliated Hospital of Guangdong Medical University; University of Science and Technology of China; Southern Medical University; Sir Run Run Shaw Hospital, Zhejiang University School of Medicine; Sun Yat Sen University
·
Nephrology
· 2023
· 10 pages
This study investigates the relationship between statin initiation and kidney outcomes in patients with type 2 diabetes mellitus, focusing on the development of kidney disease and related complications.
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Clinical reviews
THE CURRENT MANAGEMENT OF HEPATORENAL SYNDROME– ACUTE KIDNEY INJURY IN THE UNITED STATES AND THE POTENTIAL OF TERLIPRESSIN
Northwestern University Feinberg School of Medicine, Henry Ford Hospital, Mayo Clinic, Weill Cornell Medicine, South Denver Gastroenterology, Henry Ford Health System, Padua University Hospital, University of Texas Health San Antonio, University of
·
Gastroenterology
· 12 pages
This review article discusses the management of hepatorenal syndrome (HRS) and the potential use of terlipressin in treating acute kidney injury in patients with liver disease.
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Clinical reviews
MANAGEMENT OF PATIENTS WITH KIDNEY FAILURE AND PERICARDITIS
CJASN
·
Nephrology
· 2023
· 3 pages
This document discusses the management of pericarditis in patients with kidney failure, highlighting the challenges and clinical approaches in such cases.
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Clinical reviews
HYPERTENSIVE CRISIS: AN UPDATE ON CLINICAL APPROACH AND MANAGEMENT
Hospital
·
Cardiology
· 10 pages
This document reviews current concepts on hypertensive crisis (HTN-C), focusing on epidemiology, causes, pathophysiology, and prognosis, while offering a practical management approach.
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Clinical reviews
STATIN USE IS ASSOCIATED WITH LOWER RISK OF STROKE IN PATIENTS WITH ATRIAL FIBRILLATION
University of Hong Kong, China
·
Cardiology
· 2023
· 3 pages
This study evaluates the association between statin use and the incidence of stroke and transient ischaemic attack in patients diagnosed with atrial fibrillation, highlighting the protective effects of long-term statin therapy.
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Clinical reviews
INTRAOPERATIVE HANDOFFS
The University of Texas, Anesthesiology & PeriOperative Medicine; Washington University School of Medicine
·
Anesthesiology
· 12 pages
This article focuses on the subject of handoffs between anesthesia providers in the operating room, emphasizing the importance of effective communication during these transitions to ensure patient safety.
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Clinical reviews
SGLT2 INHIBITORS IN PATIENTS WITH HEART FAILURE AND CHRONIC KIDNEY DISEASE
Copenhagen University Hospital Rigshospitalet
·
Cardiology
· 3 pages
This document discusses the rapid transition of SGLT2 inhibitors from auxiliary glucose-lowering medications to essential treatments for type 2 diabetes, heart failure, and chronic kidney disease, highlighting their benefits and challenges in implementation.
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Clinical reviews
THE EMERGING CONCEPT OF FLUID TOLERANCE: A POSITION PAPER
Departamento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile; Anesthesia & Surgery Critical Care Service, Hospital Universitario Puerta del Mar, Cádiz, Spain; Chief of Service, Intensive Care Unit, Hopital Santa
·
Critical Care Medicine
· 2022
· 6 pages
This position paper reviews the concept of fluid tolerance in the context of fluid resuscitation, particularly in emergency and critical care medicine. It proposes a working definition and introduces clinical signals for assessing fluid tolerance.
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Clinical reviews
BEDAQUILINE, PRETOMANID, LINEZOLID, AND MOXIFLOXACIN: MECHANISMS OF ACTION, DRUG INTERACTIONS, ADVERSE EFFECTS AND USE IN SPECIAL SITUATIONS
Medical School, University of Araraquara (Uniara), Araraquara, Brazil
·
Infectious Disease
· 34 pages
This article provides a comprehensive pharmacological review of the BPaLM components, detailing their mechanisms of action, pharmacokinetics, and safety profiles, while analyzing critical drug interactions and providing evidence-based guidance for special clinical populations.
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Clinical reviews
ASSOCIATION OF GLYCEMIC VARIABILITY AND ULTRASOUND MUSCLE ASSESSMENT WITH PRE-SARCOPENIA IN OLDER ADULTS WITH TYPE 2 DIABETES
Nanjing Central Hospital
·
Endocrinology
· 2024
· 8 pages
This cross-sectional study investigates the association between glycemic variability and pre-sarcopenia in older adults with type 2 diabetes, utilizing muscle ultrasound for assessment.
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Clinical reviews
FUNGAL DIMORPHISM AND VIRULENCE: MOLECULAR MECHANISMS FOR TEMPERATURE ADAPTATION, IMMUNE EVASION, AND IN VIVO SURVIVAL
University of Wisconsin School of Medicine & Public Health
·
Infectious Diseases
· 2017
· 8 pages
This review discusses the thermally dimorphic fungi, focusing on their ability to switch between hyphal and yeast forms in response to temperature changes, which is crucial for their virulence. It highlights the molecular mechanisms that facilitate this phase transition and its implications for infection.
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Clinical reviews
LONG-ACTING B-2 AGONISTS (LABA) OR LONG-ACTING MUSCARINIC ANTAGONISTS (LAMA): WHICH ONE MAY BE THE FIRST OPTION IN GROUP A COPD PATIENTS?
Onur Turan, Nalan Ogan, Fulsen Bozkus, Nurhan Sarioğlu, Pakize Ayşe Turan, Celal Satıcı
·
Pulmonology
· 2024
· 7 pages
This study compares the effectiveness of long-acting muscarinic antagonists (LAMA) and beta-2 agonists (LABA) as first-line bronchodilator treatments for group A COPD patients. The findings indicate a significant improvement in symptom control with LAMA over LABA in this cohort.
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Clinical reviews
Improvement in Protective Sensation: Clinical Evidence From a Randomized Controlled Trial for Treatment of Painful Diabetic Neuropathy With 10 kHz Spinal Cord Stimulation
Diabetes Technology Society
·
Neurology
· 2024
· 7 pages
This study evaluates the long-term effects of high-frequency spinal cord stimulation on protective sensation in patients with painful diabetic neuropathy, highlighting its impact on foot ulceration risk.
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Clinical reviews
HOW TO USE LACTATE LEVELS TO GUIDE SEPTIC SHOCK RESUSCITATION: AN UPDATE
Erasmus MC University Medical Center, Bloomsbury Institute of Intensive Care Medicine
·
Intensive Care Medicine
· 4 pages
This document provides an update on the use of lactate levels in guiding resuscitation efforts for patients experiencing septic shock. It emphasizes the importance of considering lactate levels alongside other physiological variables rather than in isolation.
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Clinical reviews
EUGLYCEMIC DIABETIC KETOACIDOSIS IN THE ERA OF SGLT-2 INHIBITORS
Harbor-UCLA Medical Center, Inova Fairfax Hospital
·
Endocrinology
· 2023
· 6 pages
This review highlights the growing incidence of euglycemic diabetic ketoacidosis (EDKA) associated with SGLT-2 inhibitors, presenting a classification system for its severity and a treatment algorithm for management.
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Clinical reviews
SEVERE METABOLIC ACIDOSIS IN THE ICU
null
·
Critical Care Medicine
· 2026
· 9 pages
This article discusses severe acidemia (pH < 7.20) due to metabolic acidosis in ICU patients, its high mortality rates, and the management strategies including buffer therapy and renal replacement therapy.
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Clinical reviews
ATRIAL FIBRILLATION IN ADULTS: USE OF ORAL ANTICOAGULANTS
Warren J Manning, MD, Daniel E Singer, MD, Gregory YH Lip, MD, FRCPE, FESC, FACC
·
Cardiology
· 2026
· 39 pages
This document discusses the long-term use of oral anticoagulation in patients with atrial fibrillation to reduce the risk of ischemic stroke and other embolic events.
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Clinical reviews
DIAGNOSIS AND MANAGEMENT OF ACUTE HYPERKALAEMIA
Megan A Rech, David E Zimmerman, Lance Ray, Dharati Desai, Jean W Hoffman, Gavin T Howington
·
Nephrology
· 2026
· 20 pages
This document provides a comprehensive overview of hyperkalaemia, a potentially life-threatening electrolyte abnormality, focusing on its diagnosis and management strategies.
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