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Clinical reviews
EVALUATION AND MANAGEMENT OF NEUROLOGIC COMPLICATIONS OF SEPSIS
Vanessa F. Moreira Ferreira, MD, Anna M. Cervantes-Arslanian, MD
·
Neurology
· 12 pages
This review outlines the major neurologic syndromes encountered in the context of sepsis, including sepsis-associated encephalopathy, seizures, and cerebrovascular events. It provides a structured approach to guide clinicians in evaluating septic patients with neurologic symptoms.
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Clinical reviews
PREVENTION OF STROKE
American Academy of Neurology
·
Neurology
· 2026
· 30 pages
This article provides an overview of the principles of stroke prevention, including the distinctions among primordial, primary, secondary, and tertiary prevention.
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Clinical reviews
SEPTIC SHOCK: CURRENT OPINION IN CRITICAL CARE
Washington University
·
Critical Care
· 2026
· 8 pages
This review aims to provide a summary of recent updates in resuscitation and vasopressor strategies for septic shock, as well as advancements in precision therapy.
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Clinical reviews
Fungal Infections, Treatment and Antifungal Resistance: The Sub-Saharan African Context
Emily Boakye-Yiadom, Alex Odoom, Abdul-Halim Osman, Onyansaniba K. Ntim, Fleischer C. N. Kotey, Bright K. Ocansey, Eric S. Donkor
·
Infectious Disease
· 2024
· 25 pages
This review elaborates on the multifaceted nature of fungal resistance to available antifungal drugs and provides insights into the prevalence of fungal infections and the use of antifungal agents in sub-Saharan Africa.
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Clinical reviews
GLUCAGON-LIKE PEPTIDE-1-BASED THERAPIES IN CARDIOVASCULAR DISEASE: EVIDENCE, MECHANISMS, AND EMERGING CLINICAL APPLICATIONS
Division of Cardiology, Azienda Ospedaliero-Universitaria Policlinico 'G. Rodolico-San Marco', University of Catania
·
Cardiology
· 2026
· 16 pages
This document reviews the cardiovascular effects of glucagon-like peptide-1 (GLP-1) receptor agonists, originally developed for type 2 diabetes, and their emerging role in cardiometabolic health.
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Clinical reviews
SUPERIOR VENA CAVA FLOW IN PRETERM INFANTS AND NEONATAL OUTCOMES: A SYSTEMATIC REVIEW
Department of Pediatrics, University of Alberta; Alberta Health Services; John W. Scott Health Sciences Library, University of Alberta
·
Pediatrics
· 2022
· 9 pages
This systematic review evaluates the association between low superior vena cava (SVC) flow during the early neonatal period and various neonatal outcomes, including mortality and neurodevelopmental issues.
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Clinical reviews
CARDIOVASCULAR–KIDNEY–METABOLIC SYNDROME: MODELS OF CARE
St George's University Hospitals NHS Foundation Trust, City St George's, University of London, Apollo Multispecialty Hospitals, Instituto Nacional de Cardiologia, Institute of Post Graduate Medical Education & Research
·
Nephrology
· 2026
· 11 pages
This document reviews the complex interplay between cardiovascular disease, chronic kidney disease, and metabolic disorders, emphasizing the need for integrated care models.
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Clinical reviews
SLEEP IN CHRONIC RESPIRATORY DISEASE: COPD AND HYPOVENTILATION DISORDERS
Dept of Respiratory Medicine, School of Medicine, University College Dublin; First Affiliated Hospital of Guangzhou Medical University; Sleep Disorders Centre, Pulmonary Dept, Sahlgrenska University Hospital; Centre for Sleep and Wake Disorders,
·
Pulmonology
· 2019
· 14 pages
This document discusses the prevalence and diagnosis of sleep disordered breathing disorders, such as obstructive sleep apnea, in patients with chronic respiratory diseases like COPD. It highlights the challenges in diagnosis and the potential treatment options that may improve patient outcomes.
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Clinical reviews
CONSENSUS AND CONTROVERSIES OF INTERNATIONAL GUIDELINES FOR THE DIAGNOSIS, SURVEILLANCE, AND MANAGEMENT OF FETAL GROWTH RESTRICTION: AN UPDATED COMPARISON
Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Italy; Maternal-Fetal Medicine, Delaware Center of Maternal-Fetal Medicine, USA; Department of Women and Child Health, Fondazione Policlinico Universitario
·
Obstetrics
· 20 pages
This document provides an updated comparison of international guidelines regarding the diagnosis, surveillance, and management of fetal growth restriction (FGR), highlighting key areas of consensus and controversy.
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Clinical reviews
ABSOLUTE NOREPINEPHRINE DOSING FOR BLOOD PRESSURE RESPONSE INDEX CALCULATION: A HYPOTHESIS-GENERATING FRAMEWORK FOR FUTURE VALIDATION
Sistema Nacional de Investigadoras e Investigadores, Instituto Mexicano del Seguro Social
·
Critical Care Medicine
· 3 pages
This document proposes a framework for calculating the Blood Pressure Response Index (BPRI) using absolute norepinephrine dosing, addressing the limitations of weight-based dosing in patients with obesity.
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Clinical reviews
ATRIAL FIBRILLATION IN ADULTS: RATE CONTROL IN PATIENTS WITHOUT HEART FAILURE
Rachel Kaplan, MD, MS
·
Cardiology
· 2025
· 39 pages
This document reviews pharmacologic therapies for achieving rate control in patients with atrial fibrillation who do not have heart failure, detailing the mechanisms and evidence surrounding various treatment options.
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Clinical reviews
OVERVIEW OF THE MANAGEMENT OF CHRONIC KIDNEY DISEASE IN ADULTS
Mark Rosenberg, MD
·
Nephrology
· 2026
· 57 pages
This document provides a comprehensive overview of the management strategies for chronic kidney disease (CKD) in adults, including recent updates on treatment protocols and evidence-based recommendations.
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Clinical reviews
SURGERY AFTER UPFRONT CHEMORADIATION IN LOCALLY ADVANCED SQUAMOUS CELL VULVAR CANCER: ANALYSIS OF POSTOPERATIVE OUTCOMES AND SURVIVAL
Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; Università Cattolica del Sacro Cuore, Rome, Italy
·
Gynecologic Oncology
· 8 pages
This document analyzes the postoperative outcomes and survival rates of patients with locally advanced squamous cell vulvar cancer who underwent surgery after upfront chemoradiation.
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Clinical reviews
TREATMENT OF RHEUMATOID ARTHRITIS IN ADULTS RESISTANT TO INITIAL THERAPY
Stanley Cohen, MD; Amy Cannella, MD, MS, RhMSUS; James R O'Dell, MD; Philip Seo, MD, MHS
·
Rheumatology
· 2026
· 48 pages
This document reviews the treatment strategies for rheumatoid arthritis (RA) in adults who do not respond to initial therapy with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs). It emphasizes the importance of timely adjustments in treatment to prevent joint damage and improve patient outcomes.
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Clinical reviews
THE EFFECT OF EDUCATIONAL INTERVENTION PROGRAM ON PROMOTING PREVENTIVE BEHAVIORS OF URINARY TRACT INFECTION IN GIRLS: A RANDOMIZED CONTROLLED TRIAL
BMC
·
Pediatrics
· 2021
· 10 pages
This study investigates the impact of a Theory Planned Behavior (TPB)-based educational intervention on promoting preventive behaviors of urinary tract infection among mothers with daughters under age two.
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Clinical reviews
FROM ADIPOSITY TO MULTISYSTEM MORBIDITY: THE CASE FOR WEIGHT LOSS AS DISEASE MODIFICATION
School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK
·
Obesity Medicine
· 18 pages
This review synthesizes evidence on the impact of weight loss on various health conditions associated with obesity, including metabolic, cardiovascular, and mental health disorders. It highlights the need for further research on the efficacy of weight-loss interventions across different diseases.
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Clinical reviews
VITAMIN D DEFICIENCY
Harold N Rosen, MD
·
Endocrinology
· 2025
· 29 pages
This document discusses the causes, implications, and management of vitamin D deficiency, particularly its role in bone health and osteoporosis treatment.
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Clinical reviews
REVERSIBLE CEREBRAL VASOCONSTRICTION SYNDROMES AND PRIMARY ANGIITIS OF THE CENTRAL NERVOUS SYSTEM: CLINICAL, IMAGING, AND ANGIOGRAPHIC COMPARISON
Massachusetts General Hospital
·
Neurology
· 2016
· 13 pages
This document discusses the challenges in diagnosing reversible cerebral vasoconstriction syndromes (RCVS) and primary angiitis of the central nervous system (PACNS), comparing clinical and imaging features of both conditions.
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Clinical reviews
DRUG HYPERSENSITIVITY: EVALUATION AND MANAGEMENT
Werner J Pichler, MD
·
Allergy and Immunology
· 2024
· 40 pages
This document presents a systematic approach to evaluating patients with suspected drug allergies, particularly those on multiple medications. It discusses the classification of drug hypersensitivity reactions and the procedures for graded challenges and drug provocation tests.
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Clinical reviews
ALLERGY EVALUATION FOR IMMEDIATE PENICILLIN ALLERGY: SKIN TEST-BASED DIAGNOSTIC STRATEGIES AND CROSS-REACTIVITY WITH OTHER BETA-LACTAM ANTIBIOTICS
Kimberly G Blumenthal, MD, MSc, Roland Solensky, MD
·
Allergy and Immunology
· 2024
· 18 pages
This document discusses diagnostic strategies for evaluating immediate penicillin allergy and reviews studies on cross-reactivity with other beta-lactam antibiotics.
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Clinical reviews
DIABETIC PERIPHERAL NEUROPATHY AND ASSOCIATED FACTORS AMONG PATIENTS ATTENDING MBARARA REGIONAL REFERRAL HOSPITAL, SOUTHWESTERN UGANDA: A CROSS-SECTIONAL STUDY
Mbarara Regional Referral Hospital
·
Endocrinology
· 2025
· 10 pages
This study investigates the prevalence and factors associated with diabetic peripheral neuropathy (DPN) among patients with diabetes at Mbarara Regional Referral Hospital in Uganda.
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Clinical reviews
GOING BEYOND CYCLING VERSUS SWAPPING FOR TREATMENT SEQUENCING IN PSORIATIC ARTHRITIS
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford
·
Rheumatology
· 2026
· 2 pages
This document discusses the complexities of treatment sequencing in psoriatic arthritis (PsA) following treatment failure, emphasizing individualized strategies beyond simple cycling or swapping of therapies.
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Clinical reviews
SEX DIFFERENCES IN HUMAN AND ANIMAL TOXICOLOGY: TOXICOKINETICS
Environmental and Occupational Health Sciences Institute and Consortium for Risk Evaluation with Stakeholder Participation at Rutgers—Robert Wood Johnson Medical School
·
Toxicology
· 2017
· 39 pages
This document discusses how sex differences influence toxicokinetics and toxicodynamics in both humans and animals, highlighting the importance of considering sex in toxicological studies.
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Clinical reviews
METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE IN ADULTS
Herbert Tilg, MD; Salvatore Petta, MD; Norbert Stefan, MD; Giovanni Targher, MD
·
Gastroenterology
· 12 pages
This review discusses metabolic dysfunction-associated steatotic liver disease (MASLD), a condition characterized by fat accumulation in the liver, which can progress to more severe liver diseases. It highlights the prevalence, risk factors, and management strategies for MASLD.
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