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Clinical reviews
PHARMACOTHERAPY FOR METABOLIC DYSFUNCTION-ASSOCIATED STEATOHEPATITIS: HEART–LIVER CO-MANAGEMENT
Xiao-Dong Zhou, Jeffrey V Lazarus, Chayakrit Krittanawong, Giovanni Targher, Christopher D Byrne, Zobair M Younossi, Frank Tacke, Qin-Fen Chen, Christos S Mantzaros, Herbert Tilg, Wajahat Z Mehal, Laurence S Sperling, Gregory Y H Lip, Norbert Stefan,
·
Gastroenterology
· 17 pages
This review discusses the pharmacological management of metabolic dysfunction-associated steatohepatitis (MASH) and highlights the importance of integrated heart-liver co-management due to shared pathophysiological mechanisms with cardiovascular disease.
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Clinical reviews
VASOPRESSOR WEANING IN SEPTIC SHOCK: THE MISSING PIECE IN THE 2026 GUIDELINES
Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil
·
Critical Care Medicine
· 2026
· 2 pages
This correspondence discusses the gaps in the 2026 Surviving Sepsis Campaign guidelines regarding the de-escalation of vasopressors during septic shock stabilization. It highlights the need for further research on the optimal strategies for vasopressor withdrawal.
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Clinical reviews
DIGITAL OUTREACH TO IMPROVE STATIN REFILLS IN PATIENTS WITH LOW STATIN ADHERENCE
Kaiser Permanente Northern California
·
Cardiology
· 2025
· 11 pages
This study investigates the effectiveness of a digital outreach strategy to enhance statin refill rates among patients with low adherence, particularly those with established atherosclerotic cardiovascular disease (ASCVD).
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Clinical reviews
BLEEDING RISK WITH APIXABAN VS. RIVAROXABAN IN ACUTE VENOUS THROMBOEMBOLISM
The New England Journal of Medicine
·
Hematology
· 2026
· 10 pages
This study compares the bleeding risk associated with apixaban and rivaroxaban in patients with acute venous thromboembolism, focusing on clinically relevant bleeding events during a 3-month treatment period.
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Clinical reviews
SPONTANEOUS INTRACEREBRAL HEMORRHAGE: ACUTE TREATMENT AND PROGNOSIS
Guy Rordorf, MD, Colin T McDonald, MD
·
Neurology
· 2026
· 53 pages
This document reviews the acute treatment and prognosis of spontaneous intracerebral hemorrhage (ICH), focusing on preventing hemorrhage expansion and managing complications.
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Clinical reviews
FINERENONE IN TYPE 1 DIABETES AND CHRONIC KIDNEY DISEASE
null
·
Nephrology
· 2026
· 11 pages
This study investigates the efficacy and safety of finerenone, a nonsteroidal mineralocorticoid receptor antagonist, in adults with type 1 diabetes and chronic kidney disease (CKD).
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Clinical reviews
GENITOURINARY TRACT INFECTIONS AND SGLT2 INHIBITORS IN HEART FAILURE: AN EMPEROR-POOLED ANALYSIS
University of Porto, Centre d'Investigations Cliniques, Baylor Scott and White Research Institute, National and Kapodistrian University of Athens, German Heart Center Charité, Baylor University Medical Center, Imperial College
·
Cardiology
· 2026
· 10 pages
This document analyzes the relationship between sodium glucose co-transporter-2 inhibitors (SGLT2i) and the occurrence of genitourinary tract infections (UTIs) in patients with heart failure. It highlights the implications of UTIs on mortality risk and hospitalization.
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Clinical reviews
PUSTULAR PSORIASIS: MANAGEMENT
Robert E Kalb, MD
·
Dermatology
· 42 pages
This document provides a comprehensive overview of the management strategies for pustular psoriasis, including both generalized and localized forms. It discusses treatment options aimed at alleviating symptoms and minimizing complications.
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Clinical reviews
DEINSULINISATION IN TYPE 2 DIABETES: EVIDENCE-BASED STRATEGIES FOR SAFETREATMENT SIMPLIFICATION
Carlo B Giorda, Valentina Anelli, Umberto Goglia, Stefano De Riu, Giuseppina Russo, Marco Gallo, Salvatore De Cosmo, Gerardo Corigliano, Michele Roberto Modestino
·
Endocrinology
· 8 pages
This narrative review examines current evidence on deinsulinisation strategies in managing type 2 diabetes, focusing on the reduction or withdrawal of insulin in favor of safer therapies.
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Clinical reviews
NEOADJUVANT AND ADJUVANT PEMBROLIZUMAB PLUS CHEMOTHERAPY IN LOCALLY ADVANCED GASTRIC OR GASTRO OESOPHAGEAL CANCER (KEYNOTE-585): AN INTERIM ANALYSIS OF THE MULTICENTRE, DOUBLE-BLIND, RANDOMISED PHASE 3 STUDY
Kohei Shitara, Sun Young Rha, Lucjan S Wyrwicz, Takashi Oshima, Nina Karaseva, Mikhail Osipov, Hisateru Yasui, Hiroshi Yabusaki, Sergey Afanasyev, Young-Kyu Park, Salah-Eddin Al-Batran, Takaki Yoshikawa, Patricio Yanez, Maria Di Bartolomeo, Sara Lonardi,
·
Oncology
· 2023
· 13 pages
This document presents an interim analysis of the KEYNOTE-585 study, which investigates the efficacy of neoadjuvant and adjuvant pembrolizumab combined with chemotherapy in patients with locally advanced, resectable gastric or gastro-oesophageal adenocarcinoma.
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Clinical reviews
INTERNATIONAL CLINICAL PRACTICE GUIDELINES FOR ACUTE DEEP VEIN THROMBOSIS: A COMPARATIVE REVIEW OF RECOMMENDATIONS, EVIDENCE GAPS, AND EMERGING TRENDS
Centro Médico del Noroeste, State University of Rio de Janeiro, Hospital Pasteur, Nottingham University Hospitals NHS Trust, Kannai Medical Clinic, Icahn School of Medicine at Mount Sinai, University Hospital Porto
·
Vascular Surgery
· 17 pages
This document provides a comparative review of international clinical practice guidelines for the management of acute deep vein thrombosis (DVT), highlighting recommendations, evidence gaps, and emerging trends in the field.
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Clinical reviews
BLEEDING RISK WITH APIXABAN VS. RIVAROXABAN IN ACUTE VENOUS THROMBOEMBOLISM
The New England Journal of Medicine
·
Hematology
· 2026
· 10 pages
This study compares the bleeding risk associated with apixaban and rivaroxaban in patients with acute venous thromboembolism. It highlights the outcomes of a randomized trial assessing clinically relevant bleeding events.
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Clinical reviews
DETERMINANTS OF EJECTION FRACTION IMPROVEMENT IN HEART FAILURE PATIENTS WITH REDUCED EJECTION FRACTION
Department of Internal Medicine I, University Hospital Würzburg; Comprehensive Heart Failure Center, Würzburg, Germany
·
Cardiology
· 14 pages
This study investigates the prognostic value of dynamic changes in left ventricular ejection fraction (EF) for cardiovascular outcomes in heart failure patients with reduced EF. It identifies independent factors related to improvement in EF and risk factors for cardiovascular events.
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Clinical reviews
ACNE VULGARIS: MANAGEMENT OF MODERATE TO SEVERE ACNE IN ADOLESCENTS AND ADULTS
Emmy Graber, MD, MBA
·
Dermatology
· 2024
· 42 pages
This document provides a comprehensive overview of the management strategies for moderate to severe acne vulgaris in adolescents and adults, detailing treatment options and therapeutic approaches.
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Clinical reviews
ACNE VULGARIS: OVERVIEW OF MANAGEMENT
Emmy Graber, MD, MBA
·
Dermatology
· 2026
· 43 pages
This document provides a comprehensive overview of the management of acne vulgaris, discussing various treatment options including topical, oral, and procedural therapies. It emphasizes the importance of tailoring treatment to individual patient needs and preferences.
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Clinical reviews
A NOVEL TECHNIQUE FOR ACCESSING THE PERICARDIAL SPACE
Guangxia Wang, Huadi Qin, Lin Hou, Xiangsen Shao, Fei Xie, Hongmei Tao, Sen Lei, Fengpeng Jia, Chunchang Qin
·
Cardiology
· 2025
· 8 pages
This document presents an innovative wire puncture technique for pericardiocentesis aimed at enhancing safety in patients with challenging pericardial conditions. The method was tested in both animal models and clinical settings, demonstrating a high success rate.
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Clinical reviews
SEMAGLUTIDE AND WALKING CAPACITY IN PEOPLE WITH SYMPTOMATIC PERIPHERAL ARTERY DISEASE AND TYPE 2 DIABETES (STRIDE): A PHASE 3B, DOUBLE-BLIND, RANDOMISED, PLACEBO CONTROLLED TRIAL
University of Colorado School of Medicine, Aurora, CO, USA
·
Cardiology
· 2025
· 14 pages
This study evaluates the effects of semaglutide on walking ability and quality of life in individuals with symptomatic peripheral artery disease and type 2 diabetes. It is a phase 3b, double-blind, randomized, placebo-controlled trial conducted across multiple countries.
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Clinical reviews
SAFETY OF RHEUMATIC DISEASE MEDICATION USE DURING PREGNANCY
Bonnie L Bermas, MD
·
Rheumatology
· 2026
· 48 pages
This document reviews the risks and benefits of using medications for rheumatic diseases during pregnancy, focusing on maintaining disease control while minimizing risks to the mother and fetus.
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Clinical reviews
WEIGHT LOSS IN OLDER PATIENTS WITH PERSISTENT ATRIAL FIBRILLATION
null
·
Cardiology
· 2026
· 10 pages
This study investigates the safety and effectiveness of weight loss interventions in older patients with atrial fibrillation (AF). It focuses on whether weight loss can be beneficial without precipitating frailty in this demographic.
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Clinical reviews
EFFECTS OF EXERCISE AND INTENSIVE VASCULAR RISK REDUCTION ON COGNITIVE FUNCTION IN OLDER ADULTS
Rong Zhang, PhD; Eric Vidoni, PhD; Wanpen Vongpatanasin, MD; Diana R. Kerwin, MD; C. Munro Cullum, PhD; Heidi Rossetti, PhD; Ann M. Stowe, PhD; Sandra A. Billinger, PhD; Aditi Gupta, MD; Tristyn Hall, MBA; Norman Scheel, PhD; David C. Zhu, PhD; Linda S.
·
Neurology
· 2026
· 11 pages
This randomized clinical trial investigates the effects of exercise and intensive vascular risk reduction on cognitive function in older adults. It aims to determine whether these interventions alone or in combination yield greater cognitive benefits.
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Clinical reviews
THYROIDECTOMY
Tracy S Wang, MD, MPH, Melanie L Lyden, MD, MHPE, Julie Ann Sosa, MD, MA, FACS
·
Surgery
· 45 pages
This document discusses various surgical aspects of thyroidectomy, including preoperative evaluation and preparation, operative management, postoperative care, and complications associated with the procedure.
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Clinical reviews
COMBINED ORAL IVERMECTIN AND 5% PERMETHRIN CREAM TO TREAT SEVERE SCABIES
Bicêtre Hospital, AP-HP, Paris Saclay University Hospitals, France
·
Dermatology
· 10 pages
This article discusses the efficacy of combining oral ivermectin and topical permethrin cream for treating severe scabies, a parasitic skin disease. It highlights the lack of randomized clinical trial data and the uncertainty surrounding cure rates.
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Clinical reviews
ARTIFICIAL INTELLIGENCE IN ASTHMA: FROM DIAGNOSIS TO MANAGEMENT
Hospital Universitario Puerta de Hierro Majadahonda
·
Allergy and Immunology
· 2026
· 14 pages
This review synthesizes evidence on AI applications in diagnosis, classification, monitoring, and treatment of asthma. It highlights the potential of AI to improve asthma management across the care process.
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Clinical reviews
SPONTANEOUS INTRACEREBRAL HEMORRHAGE: SECONDARY PREVENTION AND LONG-TERM PROGNOSIS
Magdy Selim, MD, PhD
·
Neurology
· 2026
· 41 pages
This document discusses the secondary prevention and long-term prognosis of spontaneous intracerebral hemorrhage (ICH), focusing on management strategies and outcomes for affected patients.
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