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Clinical reviews
COLONOSCOPY INTERVALS AND COLORECTAL CANCER INCIDENCE AFTER ADENOMA REMOVAL
Dr. Balmis
·
Gastroenterology
· 2026
· 45 pages
This document serves as a supplementary appendix to a study on the relationship between colonoscopy intervals and colorectal cancer incidence following adenoma removal.
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Clinical reviews
COLONOSCOPY INTERVALS AND COLORECTAL CANCER INCIDENCE AFTER ADENOMA REMOVAL
EPoS Study Group
·
Gastroenterology
· 2026
· 11 pages
This document discusses the findings of a noninferiority trial examining the appropriate intervals for colonoscopy surveillance following the removal of high-risk adenomas.
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Clinical reviews
COLONOSCOPY INTERVALS AND COLORECTAL CANCER INCIDENCE AFTER ADENOMA REMOVAL
EPoS Study Group
·
Gastroenterology
· 2026
· 11 pages
This document discusses the results of an interim analysis of a trial examining the incidence of colorectal cancer based on different colonoscopy surveillance intervals after adenoma removal.
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Clinical reviews
THE INCIDENCE AND RISK FACTORS OF URINARY TRACT INFECTION IN PATIENTS WITH TYPE 2 DIABETES MELLITUS USING SGLT2 INHIBITORS: A REAL-WORLD OBSERVATIONAL STUDY
Department of Pharmaceutical Care, Walailak University, Tha Sala, Nakhon Si Thammarat, Thailand
·
Endocrinology
· 9 pages
This study investigates the incidence and risk factors of urinary tract infections (UTIs) in patients with type 2 diabetes mellitus who are treated with sodium glucose co-transporter-2 (SGLT2) inhibitors. It highlights the higher risk of UTI associated with these medications compared to non-SGLT2 inhibitors.
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Clinical reviews
MANAGEMENT OF BILE LEAK POST MINIMALLY INVASIVE SUBTOTAL CHOLECYSTECTOMY: A REVIEW
Division of General Surgery, University of Toronto; HPB Service, St. Joseph’s Health Centre; Health Sciences Centre, Winnipeg; Li Ka Shing Knowledge Institute, Unity Health Toronto
·
General Surgery
· 23 pages
This document reviews the management strategies for bile leaks following minimally invasive subtotal cholecystectomy, discussing various complications and treatment options.
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Clinical reviews
HEART FAILURE WITH MILDLY REDUCED EJECTION FRACTION: A HEART FAILURE SOCIETY OF AMERICA SCIENTIFIC STATEMENT
Heart Failure Society of America
·
Cardiology
· 2026
· 16 pages
This scientific statement provides a comprehensive review of heart failure with mildly reduced ejection fraction (HFmrEF), focusing on its epidemiology, clinical characteristics, and pathophysiology, while offering a clinical framework for treatment.
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Clinical reviews
PAST SARS-COV-2 INFECTION PROTECTION AGAINST RE-INFECTION: A SYSTEMATIC REVIEW AND META-ANALYSIS
COVID-19 Forecasting Team
·
Infectious Disease
· 2023
· 10 pages
This systematic review and meta-analysis investigates the level and characteristics of protection from past SARS-CoV-2 infection against subsequent re-infection and symptomatic COVID-19 disease. It synthesizes studies to estimate protection by variant and time since infection.
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Clinical reviews
IDENTIFYING MASLD PATIENT ELIGIBILITY FOR PHARMACOLOGICAL THERAPY: THE NEED TO INTEGRATE EVIDENCE INTO CLINICAL PRACTICE
Javier Ampuero & Manuel Romero-Gomez
·
Hepatology
· 2 pages
This document discusses the challenges in identifying suitable patients for pharmacological therapy in metabolic dysfunction-associated steatotic liver disease (MASLD), emphasizing the need for integrated approaches in clinical practice.
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Clinical reviews
CARDIOVASCULAR SUBPHENOTYPES IN SEPSIS
University Hospital ICU, Birmingham, United Kingdom
·
Critical Care Medicine
· 13 pages
This study applies unsupervised clustering methods to hemodynamic and transthoracic echocardiography parameters to identify cardiovascular subphenotypes in ICU patients with sepsis, examining their association with mortality and the impact of different hemodynamic management strategies.
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Clinical reviews
TRIPLE THERAPY WITH BUDESONIDE/GLYCOPYRROLATE/FORMOTEROL FUMARATE WITH CO-SUSPENSION DELIVERY TECHNOLOGY VERSUS DUAL THERAPIES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE (KRONOS): A DOUBLE-BLIND, PARALLEL-GROUP, MULTICENTRE, PHASE 3 RANDOMISED CONTROLLED
Gary T Ferguson, Klaus F Rabe, Fernando J Martinez, Leonardo M Fabbri, Chen Wang, Masakazu Ichinose, Eric Bourne, Shaila Ballal, Patrick Darken, Kiernan DeAngelis, Magnus Aurivillius, Paul Dorinsky, Colin Reisner
·
Pulmonology
· 12 pages
This study compares the efficacy of a triple therapy involving budesonide/glycopyrrolate/formoterol fumarate against dual therapies in patients with moderate to very severe chronic obstructive pulmonary disease (COPD). The trial involved a multicentre, double-blind, phase 3 randomized controlled design.
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Clinical reviews
PRIMARY BUDD–CHIARI SYNDROME
Juan Carlos Garcia-Pagán, M.D., Ph.D., and Dominique-Charles Valla, M.D.
·
Hepatology
· 2023
· 10 pages
This review article discusses the rare condition known as primary Budd–Chiari syndrome (BCS), characterized by obstruction of the hepatic venous outflow tract. It covers the causes, pathophysiology, and recent advances in understanding the disease.
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Clinical reviews
SQUAMOUS-CELL CARCINOMA OF THE SKIN
Department of Dermatology, University of Nebraska Medical Center
·
Dermatology
· 2023
· 12 pages
This review article discusses the prevalence, prognosis, and treatment options for squamous-cell carcinoma of the skin, which is the most common type of skin cancer in the United States.
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Clinical reviews
LATENT TUBERCULOSIS INFECTION
Johns Hopkins University School of Medicine and Medical University of South Carolina
·
Infectious Disease
· 2021
· 10 pages
This article discusses latent tuberculosis infection (LTBI), presenting a clinical vignette, evidence supporting various management strategies, and formal guidelines. It concludes with the authors' clinical recommendations for treatment.
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Clinical reviews
PRACTICE GUIDANCE FOR THE CRITICAL CARE MANAGEMENT OF SAH: Intracranial Pressure Monitoring and Management in Aneurysmal Subarachnoid Hemorrhage
Neurocrit Care
·
Neurosurgery
· 2023
· 11 pages
This review article explores the critical management of intracranial pressure (ICP) in patients with aneurysmal subarachnoid hemorrhage (SAH), emphasizing the importance of ICP monitoring and various therapeutic strategies.
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Clinical reviews
THE FENOFIBRATE ERA
null
·
Cardiology
· 2025
· 12 pages
This review critically assesses the role of fibrates in modern medicine, particularly in the context of atherosclerotic cardiovascular disease and residual cardiovascular risk in patients with mixed dyslipidaemia.
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Clinical reviews
PRIMARY PREVENTION OF STROKE AND PRESERVATION OF BRAIN
null
·
Neurology
· 2026
· 31 pages
This article provides an overview of the principles of stroke prevention, including primordial, primary, secondary, and tertiary prevention. It emphasizes guidelines for primary stroke prevention and discusses the relationship between stroke prevention and brain health.
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Clinical reviews
CONTROVERSIES SURROUNDING THE USE OF CARVEDILOL AND OTHER BETA BLOCKERS IN THE MANAGEMENT OF PORTAL HYPERTENSION AND CIRRHOSIS
Centre for Liver and Digestive Disorders, Royal Infirmary of Edinburgh; Department of Gastroenterology and Hepatology, Austin Health; Digestive Disease Research Center, Medical University of South Carolina; College of Medicine and Veterinary Medicine,
·
Gastroenterology
· 2023
· 10 pages
This review article discusses the controversies surrounding the use of carvedilol and other non-selective beta blockers in managing portal hypertension and cirrhosis. It aims to summarize the available evidence on their efficacy and safety.
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Clinical reviews
HIGH-SENSITIVITY TROPONINS AND MORTALITY IN THE GENERAL POPULATION
University of Galway School of Medicine, Johns Hopkins Hospital, Johns Hopkins University School of Medicine, University of Maryland School of Medicine
·
Cardiology
· 2023
· 11 pages
This study aimed to characterize correlations between high-sensitivity troponin assays and their associations with mortality in adults without cardiovascular disease.
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Clinical reviews
GALLSTONES
Institute
·
Surgery
· 8 pages
This article provides an overview of the management of asymptomatic cholelithiasis, etiology and epidemiology of gallstones, presentation, diagnostic workup and therapeutic approaches based on the current literature and international guidelines.
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Clinical reviews
HUMAN PAPILLOMAVIRUS VACCINATION
Centers for Disease Control and Prevention
·
Infectious Disease
· 2023
· 9 pages
This article discusses the clinical problem of genital HPV infection and presents evidence supporting various vaccination strategies, concluding with clinical recommendations from the authors.
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Clinical reviews
BRONCHIECTASIS — A CLINICAL REVIEW
Anne E. O'Donnell, M.D.
·
Pulmonology
· 2022
· 13 pages
This clinical review discusses bronchiectasis, a syndrome characterized by cough and sputum production due to abnormal bronchial wall thickening and dilation. It highlights the increasing incidence and prevalence of the condition globally, along with its socioeconomic burden.
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Clinical reviews
MAGNESIUM ADMINISTRATION FOR VASOSPASM PREVENTION IN ACUTE ANEURYSMAL SAH: A MULTICENTER RANDOMIZED CONTROLLED TRIAL
Moinay Kim, Jeong Hoon Kim, Hyunchul Jung, Seung Bin Kim, Jun Ha Hwang, Hanwool Jeon, Yeongu Chung, Youngbo Shim, Jae Hyun Kim, Joonho Byun, Aiden Cousins, Wonhyoung Park, Jung Cheol Park, Jae Sung Ahn, Seungjoo Lee
·
Neurosurgery
· 2026
· 14 pages
This study evaluates the effect of targeted serum magnesium maintenance on cerebral vasospasm and clinical outcomes following aneurysmal subarachnoid hemorrhage (aSAH). A total of 121 aSAH patients were randomized to receive either IV magnesium sulfate or placebo.
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Clinical reviews
GREAT DEBATE: IN PATIENTS WITH DECOMPENSATED HEART FAILURE, ACETAZOLAMIDE IN ADDITION TO LOOP DIURETICS IS THE FIRST CHOICE
Ziekenhuis Oost-Limburg, Hasselt University, University Hospital Jena, Hannover Medical School
·
Cardiology
· 11 pages
This document presents a debate on the use of acetazolamide in addition to loop diuretics for patients with decompensated heart failure, discussing both the advantages and disadvantages of this treatment approach.
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Clinical reviews
UPDATE ON SEPSIS TREATMENT
Journal of Intensive Care
·
Intensive Care
· 13 pages
This review synthesizes data from guidelines, translational research, and clinical trials to provide a comprehensive perspective on current management and future directions in sepsis care.
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