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Clinical reviews
NEWLY DIAGNOSED HEART FAILURE WITH REDUCED EJECTION FRACTION: TIMING, SEQUENCING, AND TITRATION OF GUIDELINE-RECOMMENDED MEDICAL THERAPY
Erasmus MC, Maastricht University Medical Centre, Ikazia Ziekenhuis, Meander Medical Centre, Noordwest Hospital Group, Haaglanden Medical Centre, Amphia Ziekenhuis, Dutch Network for Cardiovascular Research, Zuyderland Medisch Centrum, Medisch Spectrum
·
Cardiology
· 2025
· 12 pages
This document discusses the timing, sequencing, and titration of guideline-recommended medical therapy for newly diagnosed heart failure with reduced ejection fraction.
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Clinical reviews
HOW TO RECOGNIZE A TRUSTWORTHY CLINICAL PRACTICE GUIDELINE
João Pedro Lima, Reza D. Mirza, Gordon H. Guyatt
·
General Medicine
· 7 pages
This document outlines the criteria for evaluating the trustworthiness of clinical practice guidelines, emphasizing the importance of evidence-based recommendations in clinical decision-making.
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Clinical reviews
CHRONIC KIDNEY DISEASE AND CORONARY ARTERY DISEASE
American College of Cardiology
·
Cardiology
· 2019
· 16 pages
Chronic kidney disease (CKD) is a major risk factor for coronary artery disease (CAD), complicating its management due to the presence of traditional and nontraditional cardiovascular risk factors.
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Clinical reviews
ANTIPSYCHOTIC MEDICATION INFLUENCES THE DISCRIMINATIVE VALUE OF ACYLETHANOLAMIDES AS BIOMARKERS OF SUBSTANCE USE DISORDER
Grupo de Neuropsicofarmacología, IBIMA-Plataforma BIONAND, Hospital Regional Universitario de Málaga, Universidad de Málaga
·
Psychiatry
· 2023
· 16 pages
This article explores how antipsychotic medication affects the levels of acylethanolamides, which may serve as biomarkers for substance use disorders. It discusses the implications of these findings for understanding the relationship between psychiatric medications and substance use disorders.
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Clinical reviews
CONTEMPORARY MANAGEMENT OF MAJOR HAEMORRHAGE IN CRITICAL CARE
Springer-Verlag GmbH Germany, part of Springer Nature
·
Critical Care Medicine
· 2024
· 13 pages
This review discusses the complexities of managing critically ill patients experiencing major haemorrhage, emphasizing the importance of rapid treatment and individualized management protocols.
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Clinical reviews
GREAT DEBATE: CLOPIDOGREL SHOULD NOW REPLACE ASPIRIN FOR LONG-TERM SECONDARY PREVENTION OF CORONARY ARTERY DISEASE
University of Glasgow, Cardiocentro Ticino Institute, University of Bern, Catholic University School of Medicine, University of Campania 'Luigi Vanvitelli', Imperial College London, East and North Hertfordshire NHS Trust, Royal Brompton Hospital
·
Cardiology
· 14 pages
This document discusses the debate surrounding the use of clopidogrel versus aspirin for long-term secondary prevention of coronary artery disease (CAD). It presents evidence suggesting that clopidogrel may offer superior ischemic protection without the bleeding risk associated with aspirin.
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Clinical reviews
RHEUMATOID ARTHRITIS IN ADULTS
JAMA
·
Rheumatology
· 2026
· 15 pages
This document provides a comprehensive review of rheumatoid arthritis (RA), a chronic autoimmune disease that leads to inflammation and destruction of cartilage and adjacent bone, potentially resulting in irreversible disability.
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Clinical reviews
RENAL THROMBOTIC MICROANGIOPATHY: A REVIEW
null
·
Nephrology
· 2022
· 15 pages
This review discusses thrombotic microangiopathy (TMA), a pathological lesion observed in various diseases, particularly focusing on renal-limited forms of TMA. It highlights the clinical presentation, diagnostic challenges, and treatment strategies for TMA involving the kidney.
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Clinical reviews
PRACTICAL IMPLICATIONS OF THE GN-AC MATRIX AND RESEARCH PERSPECTIVES
Department of Experimental and Biomedical Sciences 'Mario Serio', Meyer Children's University Hospital, Florence, Italy; Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia;
·
Nephrology
· 2023
· 17 pages
This document discusses the classification of glomerulonephritis (GN) by pathogenesis, activity, and chronicity, emphasizing the importance of understanding these classifications for treatment decisions.
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Clinical reviews
LONG- TERM RESISTANCE TRAINING WITH ALL- CAUSE AND CAUSE- SPECIFIC MORTALITY: ASSESSING DOSE- RESPONSE AND JOINT ASSOCIATIONS WITH AEROBIC PHYSICAL ACTIVITY
Harvard T.H. Chan School of Public Health, Boston, MA, USA
·
Epidemiology
· 2024
· 10 pages
This study examines the relationship between long-term resistance training and all-cause as well as cause-specific mortality, focusing on the dose-response relationship and its joint effects with aerobic physical activity.
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Clinical reviews
ASSOCIATION BETWEEN COMBINATION ANTIBIOTIC THERAPY AS OPPOSED TO MONOTHERAPY AND OUTCOMES OF ICU PATIENTS WITH PSEUDOMONAS AERUGINOSA VENTILATOR-ASSOCIATED PNEUMONIA: AN ANCILLARY STUDY OF THE IDIAPASON TRIAL
null
·
Critical Care
· 2023
· 9 pages
This study evaluates the effectiveness of combination antibiotic therapy compared to monotherapy in patients with Pseudomonas aeruginosa ventilator-associated pneumonia (PA-VAP), focusing on mortality and recurrence rates.
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Clinical reviews
ACROMEGALY: PATHOGENESIS, DIAGNOSIS, AND MANAGEMENT
Health & Science University, Portland, OR, USA
·
Endocrinology
· 2022
· 23 pages
This document reviews the pathogenesis, diagnosis, and management of acromegaly, focusing on growth hormone-secreting pituitary adenomas. It emphasizes the importance of tailoring management strategies to optimize patient outcomes.
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Clinical reviews
DEFINITION, INCIDENCE, AND EPIDEMIOLOGY OF PEDIATRIC ACUTE RESPIRATORY DISTRESS SYNDROME: FROM THE SECOND PEDIATRIC ACUTE LUNG INJURY CONSENSUS CONFERENCE
Nadir Yehya, MD
·
Pediatrics
· 12 pages
This document discusses the definitions, incidence, and epidemiology of Pediatric Acute Respiratory Distress Syndrome (PARDS) as established by the Second Pediatric Acute Lung Injury Consensus Conference.
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Clinical reviews
SEVERE COMMUNITY-ACQUIRED PNEUMONIA: CURRENT CONCEPTS AND CONTROVERSIES
Pierre‑François Dequin, Antoni Torres, Matteo Bassetti, Miguel Ferrer, Evangelos J. Giamarellos‑Bourboulis, Ignacio Martin‑Loeches, Gianfranco Umberto Meduri, Michael S. Niederman, Chiagozie Ifeoma Pickens, Pedro Póvoa, Julio Ramirez
·
Pulmonology
· 2026
· 13 pages
This narrative review discusses severe community-acquired pneumonia (sCAP), highlighting its public health implications, treatment challenges, and the role of emerging diagnostic techniques.
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Clinical reviews
THE LINK BETWEEN REGIONAL TIDAL STRETCH AND LUNG INJURY DURING MECHANICAL VENTILATION
University of Tasmania, Monash University, Cedars-Sinai Medical Center
·
Pulmonology
· 2019
· 35 pages
This document explores the relationship between regional tidal stretch and lung injury in the context of mechanical ventilation. It examines how different ventilation strategies impact gene expression and inflammatory responses in the lungs.
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Clinical reviews
SINGLE ANTIPLATELET THERAPY DIRECTLY AFTER PERCUTANEOUS CORONARY INTERVENTION IN NON-ST-SEGMENT ELEVATION ACUTE CORONARY SYNDROME PATIENTS: THE OPTICA STUDY
Department of Cardiology, Amsterdam UMC, University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands; Department of Cardiology, Amsterdam UMC, Vrije University (VU), Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands
·
Cardiology
· 2023
· 13 pages
This study evaluates the feasibility and safety of ticagrelor or prasugrel monotherapy directly following percutaneous coronary intervention (PCI) in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS).
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Clinical reviews
RHABDOMYOLYSIS AND ACUTE KIDNEY INJURY
Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona
·
Nephrology
· 11 pages
This review article discusses the pathophysiology, diagnosis, and management of rhabdomyolysis and its potential complication, acute kidney injury.
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Clinical reviews
LIPID MANAGEMENT FOR THE PREVENTION OF ATHEROSCLEROTIC CARDIOVASCULAR DISEASE
Erin D. Michos, M.D., M.H.S., John W. McEvoy, M.B., B.Ch., Roger S. Blumenthal, M.D.
·
Cardiology
· 2019
· 11 pages
This review summarizes current methods of managing serum lipid levels to prevent atherosclerotic cardiovascular disease, highlighting the importance of cholesterol management and recent guidelines.
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Clinical reviews
NUTRITIONAL THERAPY AND A STEPWISE APPROACH IN CRITICAL ILLNESS: ALIGNING PROVISION WITH METABOLIC PHASES
Hospital
·
Critical Care Medicine
· 2025
· 9 pages
This document reviews the importance of nutritional therapy in critical care, proposing a stepwise, phase-adapted strategy that aligns nutrition with the metabolic phases of critical illness.
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Clinical reviews
MAGNESIUM AND BLOOD PRESSURE REGULATION: SYSTEMIC AND RENAL MECHANISMS
null
·
Cardiology
· 2026
· 10 pages
This document explores the relationship between magnesium deficiency and elevated blood pressure, detailing the systemic and renal mechanisms involved. It discusses the effects of magnesium supplementation on blood pressure regulation and the underlying physiological processes.
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Clinical reviews
ACUTE EXACERBATION OF INTERSTITIAL LUNG DISEASE: EARLY DIAGNOSIS AND TREATMENT
Hospital Recoletas Salud Campo Grande, Universidad de Barcelona, Hospital Universitario de la Princesa, Hospital Marqués de Valdecilla, Hospital Universitario de Burgos, Complejo Asistencial de Ávila, Hospital General de Segovia, Complejo Asistencial
·
Pulmonology
· 2025
· 12 pages
This document reviews the early diagnosis and treatment strategies for acute exacerbations of interstitial lung disease (AE-ILD). It discusses various treatment options, including the use of antibiotics and immunosuppressants, and highlights the importance of individualized treatment plans.
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Clinical reviews
ACTIVE FLUID DE-RESUSCITATION IN CRITICALLY ILL PATIENTS WITH SEPTIC SHOCK: A SYSTEMATIC REVIEW AND META-ANALYSIS
Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
·
Intensive Care Medicine
· 8 pages
This article evaluates the impact of active fluid de-resuscitation on mortality in critically ill patients with septic shock through a systematic review and meta-analysis of relevant trials.
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Clinical reviews
BRAIN MINERALOCORTICOID RECEPTOR ACTIVATION AND ANTAGONISM IN HEART FAILURE WITH PRESERVED EJECTION FRACTION: A HYPOTHESIS
Karolinska Institutet, Karolinska University Hospital, University of Michigan
·
Cardiology
· 2026
· 3 pages
This document discusses the role of brain mineralocorticoid receptors in heart failure with preserved ejection fraction, proposing a hypothesis regarding their activation and antagonism.
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Clinical reviews
GLP-1 RECEPTOR AGONISTS
Massachusetts Medical Society
·
Endocrinology
· 2026
· 12 pages
This review article discusses glucagon-like peptide-1 (GLP-1) receptor agonists, their mechanisms of action, and their use in treating type 2 diabetes and obesity.
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