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Clinical reviews
GLUCAGON-LIKE PEPTIDE-1–BASED THERAPIES IN CARDIOVASCULAR DISEASE: EVIDENCE, MECHANISMS, AND EMERGING CLINICAL APPLICATIONS
Division of Cardiology, Azienda Ospedaliero-Universitaria Policlinico ‘G. Rodolico-San Marco’, University of Catania
·
Cardiology
· 2026
· 16 pages
This document discusses the role of glucagon-like peptide-1 (GLP-1) receptor agonists as cardiometabolic agents with cardiovascular effects, particularly in patients with type 2 diabetes and elevated cardiovascular risk.
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Clinical reviews
ECHOCARDIOGRAPHY AND PULMONARY EMBOLISM
Loyola University Medical Center, Lewis Katz School of Medicine at Temple University, Thomas Jefferson University Hospital
·
Cardiology
· 21 pages
This document provides a comprehensive overview of the role of echocardiography in the assessment and management of pulmonary embolism (PE), focusing on various echocardiographic parameters and their clinical implications.
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Clinical reviews
FLUID RESTRICTION IN PATIENTS WITH HEART FAILURE: A SYSTEMATIC REVIEW
Radboud University Medical Center, Netherlands Heart Institute, Catharina Hospital, Maastricht University Medical Center, Zuyderland Medical Center, Máxima Medical Center
·
Cardiology
· 2025
· 7 pages
This systematic review assesses the efficacy and safety of fluid restriction as a non-pharmacological intervention in the management of heart failure, highlighting recent randomized clinical trial data.
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Guidelines & protocols
CRITERIA FOR THE DIAGNOSIS OF CARDIOGENIC SHOCK—EUROPEAN PERSPECTIVE: A CLINICAL CONSENSUS STATEMENT
Association for Acute CardioVascular Care, Heart Failure Association, European Association of Percutaneous Cardiovascular Interventions
·
Cardiology
· 15 pages
This document presents a clinical consensus statement on the criteria for diagnosing cardiogenic shock from a European perspective, developed by various cardiovascular associations.
6
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Clinical reviews
DIGITAL OUTREACH TO IMPROVE STATIN REFILLS IN PATIENTS WITH LOW STATIN ADHERENCE
Kaiser Permanente Northern California
·
Cardiology
· 2025
· 11 pages
This study investigates the effectiveness of a digital outreach strategy to enhance statin refill rates among patients with low adherence, particularly those with established atherosclerotic cardiovascular disease (ASCVD).
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Clinical reviews
GENITOURINARY TRACT INFECTIONS AND SGLT2 INHIBITORS IN HEART FAILURE: AN EMPEROR-POOLED ANALYSIS
University of Porto, Centre d'Investigations Cliniques, Baylor Scott and White Research Institute, National and Kapodistrian University of Athens, German Heart Center Charité, Baylor University Medical Center, Imperial College
·
Cardiology
· 2026
· 10 pages
This document analyzes the relationship between sodium glucose co-transporter-2 inhibitors (SGLT2i) and the occurrence of genitourinary tract infections (UTIs) in patients with heart failure. It highlights the implications of UTIs on mortality risk and hospitalization.
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Clinical reviews
DETERMINANTS OF EJECTION FRACTION IMPROVEMENT IN HEART FAILURE PATIENTS WITH REDUCED EJECTION FRACTION
Department of Internal Medicine I, University Hospital Würzburg; Comprehensive Heart Failure Center, Würzburg, Germany
·
Cardiology
· 14 pages
This study investigates the prognostic value of dynamic changes in left ventricular ejection fraction (EF) for cardiovascular outcomes in heart failure patients with reduced EF. It identifies independent factors related to improvement in EF and risk factors for cardiovascular events.
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Clinical reviews
A NOVEL TECHNIQUE FOR ACCESSING THE PERICARDIAL SPACE
Guangxia Wang, Huadi Qin, Lin Hou, Xiangsen Shao, Fei Xie, Hongmei Tao, Sen Lei, Fengpeng Jia, Chunchang Qin
·
Cardiology
· 2025
· 8 pages
This document presents an innovative wire puncture technique for pericardiocentesis aimed at enhancing safety in patients with challenging pericardial conditions. The method was tested in both animal models and clinical settings, demonstrating a high success rate.
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Clinical reviews
SEMAGLUTIDE AND WALKING CAPACITY IN PEOPLE WITH SYMPTOMATIC PERIPHERAL ARTERY DISEASE AND TYPE 2 DIABETES (STRIDE): A PHASE 3B, DOUBLE-BLIND, RANDOMISED, PLACEBO CONTROLLED TRIAL
University of Colorado School of Medicine, Aurora, CO, USA
·
Cardiology
· 2025
· 14 pages
This study evaluates the effects of semaglutide on walking ability and quality of life in individuals with symptomatic peripheral artery disease and type 2 diabetes. It is a phase 3b, double-blind, randomized, placebo-controlled trial conducted across multiple countries.
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Clinical reviews
WEIGHT LOSS IN OLDER PATIENTS WITH PERSISTENT ATRIAL FIBRILLATION
null
·
Cardiology
· 2026
· 10 pages
This study investigates the safety and effectiveness of weight loss interventions in older patients with atrial fibrillation (AF). It focuses on whether weight loss can be beneficial without precipitating frailty in this demographic.
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Guidelines & protocols
2024 ESC GUIDELINES FOR THE MANAGEMENT OF ELEVATED BLOOD PRESSURE AND HYPERTENSION
European Society of Cardiology (ESC)
·
Cardiology
· 2024
· 67 pages
These guidelines provide recommendations for the management of elevated blood pressure and hypertension, emphasizing the importance of transparency and ethical integrity in the development process.
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Clinical reviews
RESISTANT HYPERTENSION: EPIDEMIOLOGY, MECHANISMS AND CONTEMPORARY THERAPEUTIC STRATEGIES
Department of Cardiology, ESIC Medical College and Hospital, Faridabad, Haryana, India; Department of Cardiology, AIIMS Bhopal, Bhopal, Madhya Pradesh, India; Department of Medicine, MGM Medical College, Indore, Madhya Pradesh, India
·
Cardiology
· 14 pages
This document discusses resistant hypertension (RH), a condition characterized by uncontrolled blood pressure despite treatment, and explores its epidemiology, pathophysiology, and management strategies.
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Medicines & prescribing
CLOPIDOGREL: DRUG INFORMATION
Dr. Reddys
·
Cardiology
· 2026
· 66 pages
This document provides comprehensive drug information on Clopidogrel, including its pharmacologic category, dosing guidelines, and important alerts regarding its use in patients with specific genetic profiles.
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Clinical reviews
DIAGNOSIS AND MANAGEMENT OF RESISTANT HYPERTENSION
null
·
Cardiology
· 12 pages
This document is a review focusing on the diagnosis and management of resistant hypertension, which affects a significant percentage of patients treated for hypertension. It discusses the importance of recognizing true resistant hypertension and the appropriate treatment strategies.
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Clinical notes
DYS LIPIDEMIA
Dave L. Dixon, Daniel M. Riche, Michael S. Kelly
·
Cardiology
· 11 pages
Dyslipidemia is defined as elevated total cholesterol, low-density lipoprotein cholesterol, or triglycerides; low high-density lipoprotein cholesterol; or a combination of these abnormalities. This chapter discusses the clinical presentation, diagnosis, and treatment options for dyslipidemia.
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Clinical reviews
HEART FAILURE TRAJECTORIES AFTER GUIDELINE-DIRECTED MEDICAL THERAPY
Duy Do, PhD; Karthik Murugiah, MBBS, MHS; Mitsuaki Sawano, MD, PhD; Brianna M. Goodwin Cartwright, MS; Samuel Gratzl, PhD; Lesley H. Curtis, PhD; Nicholas L. Stucky, MD, PhD
·
Cardiology
· 4 pages
This research letter evaluates left ventricular ejection fraction (LVEF) trajectories after guideline-directed medical therapy (GDMT) in patients with heart failure with reduced ejection fraction (HFrEF). It highlights the association between patient characteristics and the use of GDMT.
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Clinical notes
CHRONIC CORONARY DISEASE
Paul P
·
Cardiology
· 8 pages
Chronic coronary disease (CCD) is a stable form of coronary artery disease (CAD) characterized by reduced myocardial blood flow from atherosclerotic narrowing or obstruction of one or more epicardial coronary arteries.
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Guidelines & protocols
HYPERTENSION IN ADULTS: DIAGNOSIS AND MANAGEMENT
National Institute for Health and Care Excellence (NICE)
·
Cardiology
· 2019
· 52 pages
This NICE guideline provides comprehensive recommendations for the diagnosis and management of hypertension in adults, emphasizing the importance of individualized patient care.
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Clinical notes
CHAPTER 12: HYPERTENSION
Eric J
·
Cardiology
· 14 pages
This chapter discusses hypertension, including its classification, clinical presentation, and management strategies based on the latest guidelines.
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Clinical reviews
CORONARY PLAQUE PROGRESSION AFTER ANDROGEN DEPRIVATION THERAPY IN MEN WITH PROSTATE CANCER
null
·
Cardiology
· 5 pages
This randomized clinical trial investigates the association between androgen deprivation therapy (ADT) and accelerated coronary atherosclerosis in men with prostate cancer, comparing the effects of GnRH agonists and antagonists.
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Medicines & prescribing
SACUBITRIL AND VALSARTAN: DRUG INFORMATION
UpToDate, Inc.
·
Cardiology
· 2026
· 40 pages
This document provides comprehensive drug information on sacubitril and valsartan, including dosing guidelines, pharmacologic categories, and safety warnings, particularly regarding fetal toxicity.
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Guidelines & protocols
MANAGEMENT OF ACUTE CORONARY SYNDROME
American College of Cardiology (ACC), American Heart Association (AHA), American College of Emergency Physicians (ACEP), National Association of EMS Physicians (NAEMSP), Society for Cardiovascular Angiography and Interventions (SCAI)
·
Cardiology
· 2025
· 2 pages
This document provides clinical guidelines for the management of patients with acute coronary syndrome (ACS), detailing recommendations for treatment and interventions.
1
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Clinical reviews
CORONARY ARTERY CALCIUM IN ACC/AHA PREVENTION GUIDELINES
Kyvan Irannejad, MD, Ruben Mora, MD, Srikanth Krishnan, MD, Suvasini Lakshmanan, MD, Sion Roy, MD, Matthew J. Budoff, MD
·
Cardiology
· 2026
· 5 pages
This editorial viewpoint discusses the evolution of coronary artery calcium (CAC) scoring in cardiovascular risk stratification as reflected in the ACC/AHA prevention guidelines from 2007 to 2026.
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Clinical notes
HEART FAILURE
Jo E
·
Cardiology
· 12 pages
This chapter provides a comprehensive overview of heart failure (HF), including its definitions, clinical presentations, diagnosis, and management strategies.
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